MRPL10

  • Official Full Name

    mitochondrial ribosomal protein L10

  • Overview

    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.
  • Synonyms

    MRPL10; mitochondrial ribosomal protein L10; 39S ribosomal protein L10, mitochondrial; 39S ribosomal protein L10; mitochondrial; L10MT; MGC17973; MRP L8; MRP L10; MRPL8; RPML8; 39S ribosomal protein L10 mitochondrial; 39S ribosomal protein L10 mitochondrial precursor; MRPL 10; L8mt; 39S ribosomal protein L8, mitochondrial; MRP-L8; MRP-L10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MRPL10-977H Recombinant Human MRPL10, His-tagged E.coli His 1-261aa
Human MRPL10-4199HCL Recombinant Human MRPL10 293 Cell Lysate HEK293 N/A
Human MRPL10-5554H Recombinant Human MRPL10 Protein, GST-tagged Wheat Germ GST
Human MRPL10-6377HF Recombinant Full Length Human MRPL10 Protein, GST-tagged In Vitro Cell Free System GST 261 amino acids
Rhesus Macaque MRPL10-2831R Recombinant Rhesus monkey MRPL10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MRPL10-2651R Recombinant Rhesus Macaque MRPL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MRPL10-2651R-B Recombinant Rhesus Macaque MRPL10 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MRPL10-2146Z Recombinant Zebrafish MRPL10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MRPL10 involved in several pathways and played different roles in them. We selected most pathways MRPL10 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mitochondrial translationMRPS23;MRPL45;AURKAIP1;MRPL46;GADD45GIP1;ICT1;MRPS25;MRPL41;GFM1
Mitochondrial translation elongationMRPL52;MRPL42;MRPS31;ICT1;AURKAIP1;DAP3;MRPS34;MRPS23;MRPS33
Mitochondrial translation initiationGADD45GIP1;MRPL55;MRPL49;MRPS22;PTCD3;MRPL41;MRPL10;MRPS31;MRPS35
Mitochondrial translation terminationGADD45GIP1;MRPS25;MRPL39;MRPL52;MRPL10;ICT1;MRPL37;MRPL48;MRPL47
Organelle biogenesis and maintenanceMRPL51;IFT122;MRPL42;IFT81;WDR19;MRPS36;TTC30A2;MRPS34;UNC119B
RibosomeMRPL2;RPL18A;RPL10;RPS27A;MRPL13;RPS10;MRPL30;RPL24;MRPL21

MRPL10 has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL10 itself. We selected most functions MRPL10 had, and list some proteins which have the same functions with MRPL10. You can find most of the proteins on our site.

Function Related Protein
poly(A) RNA bindingSMNDC1;AKAP17A;FASTKD1;PTBP1;NOC2L;DDX3X;NSUN5;RBPMS;RSL1D1
protein bindingSYNPO2L;BAG6;COMMD1;AHCYL2;DMPK;CD69;WRNIP1;ERCC5;PLIN3
structural constituent of ribosomeRPL13A;MRPL14;MRPS24;RPS6;SLC25A38A;RPS18;MRPL34;MRPL17;MRPL20

MRPL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL10.

TCF4; REL; KLHL12; FAM9B; PNMA1; USP22; ICT1; MRPL50; MRPL9; MRPL1

Research Area

Related articles

Han, MJ; Cimen, H; et al. Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION 78:48-54(2011).
Koc, EC; Yang, YJ; et al. NAD plus -dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of mitochondrial ribosomal protein L10. FASEB JOURNAL 24:-(2010).
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