MRPL10 Protein


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Official Full Name mitochondrial ribosomal protein L10
Background Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.
Synonyms MRPL10; mitochondrial ribosomal protein L10; 39S ribosomal protein L10, mitochondrial; 39S ribosomal protein L10; mitochondrial; L10MT; MGC17973; MRP L8; MRP L10; MRPL8; RPML8; 39S ribosomal protein L10 mitochondrial; 39S ribosomal protein L10 mitochondrial precursor; MRPL 10; L8mt; 39S ribosomal protein L8, mitochondrial; MRP-L8; MRP-L10
    • Species :
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MRPL10-977H Recombinant Human MRPL10, His-tagged E.coli His
    Rhesus Macaque MRPL10-2831R Recombinant Rhesus monkey MRPL10 Protein, His-tagged Mammalian Cell His
    Zebrafish MRPL10-2146Z Recombinant Zebrafish MRPL10 Mammalian Cell His
    Human MRPL10-4199HCL Recombinant Human MRPL10 293 Cell Lysate HEK293 N/A
    Human MRPL10-6377HF Recombinant Full Length Human MRPL10 Protein, GST-tagged In Vitro Cell Free System GST
    Human MRPL10-5554H Recombinant Human MRPL10 Protein, GST-tagged Wheat Germ GST

    MRPL10 involved in several pathways and played different roles in them. We selected most pathways MRPL10 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial translation MTIF3; MRPL10; MRPL44; PTCD3; MRPL28; GFM1; GADD45GIP1; MRPL48; MRPS36; MRPL51
    Mitochondrial translation elongation MRPL52; MRPS36; MRPL42; CHCHD1; ICT1; MRPL37; GFM1; MRPS25; MRPL51; MRPL46
    Mitochondrial translation initiation MRPS28; PTCD3; MRPL10; MRPL39; MRPS36; MRPL47; MRPL49; MRPL37; MRPL38; MRPS24
    Mitochondrial translation termination MRPL42; MRPL52; MRPL54; GADD45GIP1; ICT1; CHCHD1; MRPL10; MRPS31; MRPS33; MRPL37
    Organelle biogenesis and maintenance MRPS35; PPRC1; TRAF3IP1; TSFM; MRPL52; TRIP11; TTC8; MTIF3; MRPL50; MRRF
    Ribosome MRPS14; MRPL32; RPL36A-HNRNPH2; RPS27; RPS15A; RPS11; MRPL17; RPL3L; MRPL27; RPL7

    MRPL10 has several biochemical functions, for example, poly(A) RNA binding, protein binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL10 itself. We selected most functions MRPL10 had, and list some proteins which have the same functions with MRPL10. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding YTHDF3; RPS24; EIF4A3; SEC23IP; FDPS; EXOSC7; ZFP346; ELAC2; MOV10; ZC3H15
    protein binding MCM3; CXCL2; MMP3; OLFM3; USP5; IKBKE; VAV1; PACS1; UBE2H; DNAJC15
    structural constituent of ribosome RPL8; MRPS24; RPL5A; MRPL49; RPS27.1; RPL10L; RPL24; RPL35; MRPL17; MRPS34

    MRPL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL10.


    Han, MJ; Cimen, H; et al. Purification of human mitochondrial ribosomal L7/L12 stalk proteins and reconstitution of functional hybrid ribosomes in Escherichia coli. PROTEIN EXPRESSION AND PURIFICATION 78:48-54(2011).
    Koc, EC; Yang, YJ; et al. NAD plus -dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of mitochondrial ribosomal protein L10. FASEB JOURNAL 24:-(2010).

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