MRPL2

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MRPL2

Official Full Name mitochondrial ribosomal protein L2
Background Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q.
Synonyms MRPL2; mitochondrial ribosomal protein L2; 39S ribosomal protein L2, mitochondrial; CGI 22; MRP L14; RPML14; 39S ribosomal protein L2, mitochondrial precursor; CGI22; MRPL14; L2mt; MRP-L2; CGI-22; MRP-L14
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MRPL2-4190HCL Recombinant Human MRPL2 293 Cell Lysate HEK293 N/A
    Human MRPL2-5564H Recombinant Human MRPL2 Protein, GST-tagged Wheat Germ GST
    Human MRPL2-681H Recombinant Human mitochondrial ribosomal protein L2, His-tagged E.coli His
    Human MRPL2-987H Recombinant Human MRPL2, GST-tagged E.coli GST
    Mouse Mrpl2-1398M Recombinant Mouse Mrpl2 protein, His & T7-tagged E.coli His/T7
    Rat MRPL2-3766R Recombinant Rat MRPL2 Protein Mammalian Cell His

    MRPL2 involved in several pathways and played different roles in them. We selected most pathways MRPL2 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ribosome MRPS12; RPS16; RPSA; RPL41; MRPL14; MRPL27; MRPL9; RPL30; RPS8A; RPS4X

    MRPL2 has several biochemical functions, for example, poly(A) RNA binding, structural constituent of ribosome, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL2 itself. We selected most functions MRPL2 had, and list some proteins which have the same functions with MRPL2. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding SLC3A2; HNRNPA1; HIST1H4L; SAMSN1; RALYL; HIST1H4E; C1orf35; KIAA1967; LTA4H; FAM133B
    structural constituent of ribosome RPL17; RPSA; RPS26L; RPS21; RPL27; MRPL3; RPS19; RPL19; RPS29; RPL23
    transferase activity MBOAT4; SGK2A; TPST1L; UGT5C1; HS6ST1A; SPTLC2B; XYLT1; AKT3A; UGT5B2; ZDHHC16B

    MRPL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL2.

    CMTM4; TRIM63; SMURF2; Brwd3; Ncstn; YBX1; ICT1; EZH2; MRPL50; MASTL; MRPL9; MRPL1

    van der Giezen, M; Birdsey, GM; et al. Fungal hydrogenosomes contain mitochondrial heat-shock proteins. MOLECULAR BIOLOGY AND EVOLUTION 20:1051-1061(2003).

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