MRPL3

  • Official Full Name

    mitochondrial ribosomal protein L3

  • Overview

    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.
  • Synonyms

    MRPL3; mitochondrial ribosomal protein L3; RPML3; 39S ribosomal protein L3, mitochondrial; MRL3; L3mt; Mitochondrial 39S ribosomal protein L3; mitochondrial 60S ribosomal protein L3; mitochondrial ribosomal protein; MRP-L3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MRPL3-994H Recombinant Human MRPL3, GST-tagged E.coli GST 1-348aa
Human MRPL3-4181HCL Recombinant Human MRPL3 293 Cell Lysate HEK293 N/A
Human MRPL3-6436HF Recombinant Full Length Human MRPL3 Protein, GST-tagged In Vitro Cell Free System GST 348 amino acids
Human MRPL3-5573H Recombinant Human MRPL3 Protein, GST-tagged Wheat Germ GST
Mouse MRPL3-10058M Recombinant Mouse MRPL3 Protein Mammalian Cell His
Mouse MRPL3-5694M Recombinant Mouse MRPL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MRPL3-5694M-B Recombinant Mouse MRPL3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MRPL3-10368Z Recombinant Zebrafish MRPL3 Mammalian Cell His
Chicken MRPL3-1509C Recombinant Chicken MRPL3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MRPL3 Related Articles

MRPL3 involved in several pathways and played different roles in them. We selected most pathways MRPL3 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mitochondrial translationMRPL50;MRPL48;PTCD3;MRPL51;AURKAIP1;MRPS24;MRPS26;MRPS30;MTRF1L
Mitochondrial translation elongationMRPL39;MRPL51;MRPS33;MRPL45;MRPS26;MRPS27;MRPL42;MRPL40;MRPL50
Mitochondrial translation initiationMRPS22;MRPS33;MRPL49;MRPL47;MRPS24;CHCHD1;MRPL28;MRPL40;MTFMT
Mitochondrial translation terminationAURKAIP1;MRPL44;MRRF;MRPL38;MRPS34;MRPS24;MRPL48;MRPS26;MRPL39
Organelle biogenesis and maintenanceTMEM216;POLG2;B9D1;MTERF;MRPS22;NPHP3;MRPS31;MRPS27;MTRF1L
RibosomeRPS3;MRPS5;RPL34-PS1;RPL35A;RPLP2;RPL7;MRPL4;FAUA;MRPL18

MRPL3 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL3 itself. We selected most functions MRPL3 had, and list some proteins which have the same functions with MRPL3. You can find most of the proteins on our site.

Function Related Protein
RNA bindingALYREF;PPARGC1B;DAZAP1;RPLP0;MOV10B.1;FMR1;RPL8;ADARB1;ELAVL4
poly(A) RNA bindingLGALS3;HSP90AB1;MATR3;EZR;HNRPDL;MRPS26;EDF1;DROSHA;MRPL9
structural constituent of ribosomeRPL35A;RPL3;RPL18A;RPL14;MRPS22;MRPL20;RPL22;RPS9;MRPL47

MRPL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL3.

ICT1; C1qbp; Nfya; CENPA; YBX1; Bach1; Gbf1; Gpsm1; Topbp1; MRPL50; Ccdc12; NAF1; SCAF11; MRPL20; MRPL9; MRPL1; Vps28; TIMM13

Ridlon, L; Skodova, I; et al. The Importance of the 45 S Ribosomal Small Subunit-related Complex for Mitochondrial Translation in Trypanosoma brucei. JOURNAL OF BIOLOGICAL CHEMISTRY 288:32963-32978(2013).
Dzido, J; Kijewska, A; et al. Selected mitochondrial genes as species markers of the Arctic Contracaecum osculatum complex. JOURNAL OF HELMINTHOLOGY 86:252-258(2012).
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