MRPL3
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Official Full Name
mitochondrial ribosomal protein L3 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. -
Synonyms
MRPL3;mitochondrial ribosomal protein L3;RPML3;39S ribosomal protein L3, mitochondrial;MRL3;L3mt;Mitochondrial 39S ribosomal protein L3;mitochondrial 60S ribosomal protein L3;mitochondrial ribosomal protein;MRP-L3
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MRPL3-994H | Recombinant Human MRPL3, GST-tagged | E.coli | Human | GST | 1-348aa | |
| MRPL3-10058M | Recombinant Mouse MRPL3 Protein | Mammalian Cells | Mouse | His |
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| MRPL3-10368Z | Recombinant Zebrafish MRPL3 | Mammalian Cells | Zebrafish | His |
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| MRPL3-1509C | Recombinant Chicken MRPL3 | Mammalian Cells | Chicken | His |
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| MRPL3-4181HCL | Recombinant Human MRPL3 293 Cell Lysate | HEK293 | Human | Non |
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| MRPL3-5573H | Recombinant Human MRPL3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| MRPL3-5694M | Recombinant Mouse MRPL3 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| MRPL3-5694M-B | Recombinant Mouse MRPL3 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| MRPL3-6436HF | Recombinant Full Length Human MRPL3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 348 amino acids |
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Involved Pathway
MRPL3 involved in several pathways and played different roles in them. We selected most pathways MRPL3 participated on our site, such as Mitochondrial translation,Mitochondrial translation elongation,Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial translation initiation | CHCHD1,MRPL39,MRPS23,MRPS30,MRPL48,ICT1,AURKAIP1,MRPL46,MRPL38,MRPS34 |
| Organelle biogenesis and maintenance | EXOC5,BBS4,RP2,CYS1,CHCHD1,CNGA5,TFB1M,KIFAP3B,MTFMT,MRPL47 |
| Ribosome | RPL32,RPL5,RPL18,RPL22L1,RPS3A,RPS8,RPS23,RPS13,UBA52,MRPS10 |
| Mitochondrial translation termination | GADD45GIP1,MRPS22,MRPS27,MRPS34,MRPS31,MRPS25,MTRF1L,MRPL53,MRPL10,GFM2 |
| Mitochondrial translation elongation | DAP3,MRPS31,MRPL40,TSFM,MRPL47,MRPS26,PTCD3,MRPS25,MRPL54,CHCHD1 |
| Mitochondrial translation | AURKAIP1,GADD45GIP1,MRPL44,MRPL45,MTIF3,MRPL50,MRPL28,MRPL37,MRPL53,MRPL55 |
Protein Function
MRPL3 has several biochemical functions, for example, RNA binding,poly(A) RNA binding,structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL3 itself. We selected most functions MRPL3 had, and list some proteins which have the same functions with MRPL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | GANAB,PARP12,SRSF11,PRPF3,STRAP,BUD13,LUC7L3,EPPK1,EFTUD2,CCDC137 |
| structural constituent of ribosome | RPLP2L,RPL36AL,RPL3,RPL22,RPL10A,RPL10L,RPS26,RPS4Y1,FAU,RPS8A |
| RNA binding | CSTF3,SRSF1A,GRB7,DNAJC17,CELF1,AGO3B,EIF2S1A,FBL,C14orf166,KHSRP |
Interacting Protein
MRPL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL3.
ICT1;C1qbp;Nfya;CENPA;YBX1;Bach1;Gbf1;Gpsm1;Topbp1;MRPL50;Ccdc12;NAF1;SCAF11;MRPL20;MRPL9;MRPL1;Vps28;TIMM13
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References
- Ridlon, L; Skodova, I; et al. The Importance of the 45 S Ribosomal Small Subunit-related Complex for Mitochondrial Translation in Trypanosoma brucei. JOURNAL OF BIOLOGICAL CHEMISTRY 288:32963-32978(2013).
- Dzido, J; Kijewska, A; et al. Selected mitochondrial genes as species markers of the Arctic Contracaecum osculatum complex. JOURNAL OF HELMINTHOLOGY 86:252-258(2012).
