MRPL3 Protein


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Official Full Name mitochondrial ribosomal protein L3
Background Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.
Synonyms MRPL3; mitochondrial ribosomal protein L3; RPML3; 39S ribosomal protein L3, mitochondrial; MRL3; L3mt; Mitochondrial 39S ribosomal protein L3; mitochondrial 60S ribosomal protein L3; mitochondrial ribosomal protein; MRP-L3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MRPL3-994H Recombinant Human MRPL3, GST-tagged E.coli GST Inquiry
    Mouse MRPL3-10058M Recombinant Mouse MRPL3 Protein Mammalian Cell His Inquiry
    Chicken MRPL3-1509C Recombinant Chicken MRPL3 Mammalian Cell His Inquiry
    Zebrafish MRPL3-10368Z Recombinant Zebrafish MRPL3 Mammalian Cell His Inquiry
    Human MRPL3-4181HCL Recombinant Human MRPL3 293 Cell Lysate HEK293 N/A Inquiry
    Mouse MRPL3-5694M Recombinant Mouse MRPL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MRPL3-6436HF Recombinant Full Length Human MRPL3 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human MRPL3-5573H Recombinant Human MRPL3 Protein, GST-tagged Wheat Germ GST Inquiry

    MRPL3 involved in several pathways and played different roles in them. We selected most pathways MRPL3 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial translation MRPL50; MTIF3; MRPS24; MRPS28; MRPL10; PTCD3; MRPL52; MRPL39; MRPL55; MRPL47
    Mitochondrial translation elongation MRPS26; MRPS33; MRPL55; MRPS35; MRPS30; MRPL52; ICT1; MRPL47; MRPS31; MRPL3
    Mitochondrial translation initiation MRPS34; MRPS23; MRPL10; MRPS35; MRPS33; CHCHD1; MRPL48; MTIF3; ICT1; MRPL40
    Mitochondrial translation termination MRPL41; MRPS27; GFM2; MRPL54; MRPL44; MTRF1L; MRPL49; MRPS30; ICT1; MRPS34
    Organelle biogenesis and maintenance HSPB11; B9D1; TNPO1; FBF1; BBS13; RP2; BBS12; MRPL47; SCLT1; PKD2
    Ribosome RPS3; RPS9; MRPL15; RPL24; RPL28; RPL22L1; RPL10; MRPS10; RPS20; RPL3

    MRPL3 has several biochemical functions, for example, RNA binding, poly(A) RNA binding, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL3 itself. We selected most functions MRPL3 had, and list some proteins which have the same functions with MRPL3. You can find most of the proteins on our site.

    Function Related Protein
    RNA binding RPL4; PUS3; TLR13; HNRNPF; EIF4G2B; NPM1; MRPL12; DHX34; DKC1; DNAJC17
    poly(A) RNA binding LGALS1; RPS11; HERC5; ISY1; ETF1A; CIRH1A; RPS20; FAM133B; RBM47; ZNF385A
    structural constituent of ribosome RPS17L; RPS27.2; RPL19; MRPS22; MRPS2; RPL18; MRPL23; RPS8B; RPLP1; MRPS34

    MRPL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL3.

    ICT1; C1qbp; Nfya; CENPA; YBX1; Bach1; Gbf1; Gpsm1; Topbp1; MRPL50; Ccdc12; NAF1; SCAF11; MRPL20; MRPL9; MRPL1; Vps28; TIMM13

    Ridlon, L; Skodova, I; et al. The Importance of the 45 S Ribosomal Small Subunit-related Complex for Mitochondrial Translation in Trypanosoma brucei. JOURNAL OF BIOLOGICAL CHEMISTRY 288:32963-32978(2013).
    Dzido, J; Kijewska, A; et al. Selected mitochondrial genes as species markers of the Arctic Contracaecum osculatum complex. JOURNAL OF HELMINTHOLOGY 86:252-258(2012).

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