Official Full Name
mitochondrial ribosomal protein L46
BackgroundMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
SynonymsMRPL46; mitochondrial ribosomal protein L46; C15orf4, chromosome 15 open reading frame 4; 39S ribosomal protein L46, mitochondrial; LIECG2; P2ECSL; mitochondrial; 39S ribosomal protein L46; 39S ribosomal protein L46 mitochondrial; C15orf4; L46mt; LIECG 2; MGC22762; MRP L46; MRP-L46; MRPL 46; RM46_HUMAN;