MRPL46

  • Official Full Name

    mitochondrial ribosomal protein L46

  • Overview

    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
  • Synonyms

    MRPL46; mitochondrial ribosomal protein L46; C15orf4, chromosome 15 open reading frame 4; 39S ribosomal protein L46, mitochondrial; LIECG2; P2ECSL; mitochondrial; 39S ribosomal protein L46; 39S ribosomal protein L46 mitochondrial; C15orf4; L46mt; LIECG 2; MGC22762; MRP L46; MRP-L46; MRPL 46; RM46_HUMAN;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MRPL46-1009H Recombinant Human MRPL46, His-tagged E.coli His
Human MRPL46-4163HCL Recombinant Human MRPL46 293 Cell Lysate HEK293 N/A
Human MRPL46-5589H Recombinant Human MRPL46 Protein, GST-tagged Wheat Germ GST
Human MRPL46-2798H Recombinant Human MRPL46 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MRPL46-6427HF Recombinant Full Length Human MRPL46 Protein, GST-tagged In Vitro Cell Free System GST
Mouse MRPL46-10073M Recombinant Mouse MRPL46 Protein Mammalian Cell His
Mouse Mrpl46-4159M Recombinant Mouse Mrpl46 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MRPL46-5705M Recombinant Mouse MRPL46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MRPL46-5705M-B Recombinant Mouse MRPL46 Protein Pre-coupled Magnetic Beads HEK293
Rat MRPL46-3775R Recombinant Rat MRPL46 Protein Mammalian Cell His
Rat MRPL46-3434R-B Recombinant Rat MRPL46 Protein Pre-coupled Magnetic Beads HEK293
Rat MRPL46-3434R Recombinant Rat MRPL46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MRPL46-642Z Recombinant Zebrafish MRPL46 Mammalian Cell His
Chicken MRPL46-4728C Recombinant Chicken MRPL46 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MRPL46 involved in several pathways and played different roles in them. We selected most pathways MRPL46 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Mitochondrial translationMRPS34;MRPS30;MRPL49;MRPL53;MRPS26;MRPS27;MRPS24;MRPL45;MRPL38
Mitochondrial translation elongationMRPL51;MRPL46;MRPS35;MRPL40;MRPL42;MRPS34;MRPS33;PTCD3;MRPL28
Mitochondrial translation initiationMRPL42;MRPS22;MRPS31;MRPL41;MRPS36;MRPL50;MRPS27;MRPL51;MRPL44
Mitochondrial translation terminationMRPL41;MRPL45;ICT1;MRPL53;MRPL55;MRPL37;MRPL28;MRPS26;GFM2
Organelle biogenesis and maintenanceMRPL3;NPHP4;TMEM216;C11orf60;EXOC3;GFM1;EXOC6;MRPS33;AURKAIP1

MRPL46 has several biochemical functions, for example, hydrolase activity, molecular_function, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL46 itself. We selected most functions MRPL46 had, and list some proteins which have the same functions with MRPL46. You can find most of the proteins on our site.

Function Related Protein
hydrolase activityAcr;PRSS59.2;DUSP22B;CES1C;ACP5B;RNASEKA;HDAC9B;CLCA5;ABHD13
molecular_functionARHGAP36;SSX2IPA;TMEM131;ZPCX;HIST1H2BA;FAM198A;CMYA5;OSGIN2;PANE1
structural constituent of ribosomeMRPL17;MRPL55;MRPL28;MRPS31;RPS4Y1;RPS26;RPL22;RPL3;MRPL41

MRPL46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL46 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL46.

Brwd3; Srp72; C1qbp; SLC25A5; RPL10; HNRNPU; ICT1; Rpl35; MRPL50; MRPL9

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