MRPL46 Protein


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Official Full Name mitochondrial ribosomal protein L46
Background Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
Synonyms MRPL46; mitochondrial ribosomal protein L46; C15orf4, chromosome 15 open reading frame 4; 39S ribosomal protein L46, mitochondrial; LIECG2; P2ECSL; mitochondrial; 39S ribosomal protein L46; 39S ribosomal protein L46 mitochondrial; C15orf4; L46mt; LIECG 2; MGC22762; MRP L46; MRP-L46; MRPL 46; RM46_HUMAN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MRPL46-1009H Recombinant Human MRPL46, His-tagged E.coli His
    Mouse MRPL46-10073M Recombinant Mouse MRPL46 Protein Mammalian Cell His
    Rat MRPL46-3775R Recombinant Rat MRPL46 Protein Mammalian Cell His
    Chicken MRPL46-4728C Recombinant Chicken MRPL46 Mammalian Cell His
    Zebrafish MRPL46-642Z Recombinant Zebrafish MRPL46 Mammalian Cell His
    Human MRPL46-4163HCL Recombinant Human MRPL46 293 Cell Lysate HEK293 N/A
    Human MRPL46-6427HF Recombinant Full Length Human MRPL46 Protein, GST-tagged In Vitro Cell Free System GST
    Human MRPL46-2798H Recombinant Human MRPL46 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MRPL46-5589H Recombinant Human MRPL46 Protein, GST-tagged Wheat Germ GST
    Mouse Mrpl46-4159M Recombinant Mouse Mrpl46 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MRPL46 involved in several pathways and played different roles in them. We selected most pathways MRPL46 participated on our site, such as Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial translation ICT1; TUFM; MRPL37; MRPS35; MRPL52; DAP3; MTIF3; MRPS25; MRRF; MRPL49
    Mitochondrial translation elongation MRPS23; MRPL55; MRPL42; MRPS24; MRPS31; MRPS35; MRPL38; MRPL53; MRPS22; MRPS36
    Mitochondrial translation initiation MRPL53; MRPL39; MRPS35; MRPS25; MRPS31; MRPL10; DAP3; MRPS36; CHCHD1; MRPL55
    Mitochondrial translation termination MRPL28; MRPL50; MRRF; MRPS36; MRPL40; MRPL42; ICT1; MRPL41; MRPL46; MRPL38
    Organelle biogenesis and maintenance GADD45GIP1; MTRF1L; MRPL38; BBS9; DYNLRB2; TSFM; OST4; BBS13; TFB1M; DYNLL2A

    MRPL46 has several biochemical functions, for example, hydrolase activity, molecular_function, structural constituent of ribosome. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL46 itself. We selected most functions MRPL46 had, and list some proteins which have the same functions with MRPL46. You can find most of the proteins on our site.

    Function Related Protein
    hydrolase activity OTUB1B; NUDT17; PRSS30; CHD8; HTRA1A; Ces2e; PPAP2C; MRPL46; PPEF2; TP53RK
    molecular_function THADA; DEFB39; PCNXL3; Aadacl3; ATG2A; TMEM51; MFSD5; TTC18; XLR; TMEM150C
    structural constituent of ribosome RPL29; RPL15; MRPL22; RPL17; RPL36; MRPS2; MRPS34; RPL34; RPL14; MRPL41

    MRPL46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL46 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL46.

    Brwd3; Srp72; C1qbp; SLC25A5; RPL10; HNRNPU; ICT1; Rpl35; MRPL50; MRPL9

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