MSH4
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Official Full Name
mutS homolog 4 (E. coli) -
Overview
MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene. -
Synonyms
MSH4;mutS homolog 4 (E. coli);mutS protein homolog 4;MutS homolog 4 variant iota 1;MutS homolog 4 variant theta 1;mMsh4;AV144863;4930485C04Rik
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| MSH4-4119HCL | Recombinant Human MSH4 293 Cell Lysate | HEK293 | Human | Non |
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| MSH4-5651H | Recombinant Human MSH4 Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
MSH4 involved in several pathways and played different roles in them. We selected most pathways MSH4 participated on our site, such as Cell Cycle,Meiosis,Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Meiosis | TERF2IP,TERF1,MND1,DIDO1,TINF2,POT1,TERF2,SYNE1,SUN1,DMC1 |
| Cell cycle | ENSAA,TGFB1A,CDC26,YWHAQ,CHEK1,POLD3,MYCA,CENPA,TOP2A,TGFB1 |
| Meiotic recombination | MSH5,PSMC3IP,DMC1,SPO11,TEX15,MND1 |
Protein Function
MSH4 has several biochemical functions, for example, ATP binding,DNA binding,DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH4 itself. We selected most functions MSH4 had, and list some proteins which have the same functions with MSH4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | DMRT3A,DNAJC1,HMGXB3,RUNX1,NEUROG1,APLP2,ASXL1,SMAD3B,HOXD13A,NPAS4 |
| ATP binding | HELZ,STRADA,GATC,DMPK,C9orf96,CLK1,FAM20C,PIF1,ATAD1,MYO6A |
| NOT damaged DNA binding | MSH5 |
| protein binding | PRPSAP1,TMEM132D,EMD,TEAD1,SVIL,UBC,PDE9A,GOLGA3,PSMD9,SPATA24 |
| DNA-dependent ATPase activity | ERCC2,MSH2,RAD51C,TTF2,SMARCA4,XRCC3,MSH6,RAD51L1,CDK7,SMARCAL1 |
| mismatched DNA binding | MLH3,MSH5,MSH6,MLH1,PMS1,TDG |
Interacting Protein
MSH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH4.
MSH5;EIF3F;ABL1
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References
- Namadurai, S; Jain, D; et al. The C-Terminal Domain of the MutL Homolog from Neisseria gonorrhoeae Forms an Inverted Homodimer. PLOS ONE 5:-(2010).
- Douglas, JA; Gruber, SB; et al. History and molecular genetics of Lynch syndrome in family G - A century later. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 294:2195-2202(2005).
