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MXD3

  • Official Full Name

    MAX dimerization protein 3

  • Overview

    This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators.;The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters;of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled;cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been;described.
  • Synonyms

    MXD3; MAX dimerization protein 3; bHLHc13; MAD3; FLJ35523; Likely ortholog of mouse Max dimerization protein 3; MGC2383; MYX; OTTHUMP00000223596; OTTHUMP00000223598; max dimerizer 3; Max-associated protein 3; class C basic helix-loop-helix protein 13; Max-interacting transcriptional repressor MAD3;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MXD3-4047HCL Recombinant Human MXD3 293 Cell Lysate HEK293 N/A
Human MXD3-5775H Recombinant Human MXD3 Protein, GST-tagged Wheat Germ GST
Human MXD3-1631H Recombinant Human MXD3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MXD3-6633HF Recombinant Full Length Human MXD3 Protein, GST-tagged In Vitro Cell Free System GST 206 amino acids
Mouse MXD3-10272M Recombinant Mouse MXD3 Protein Mammalian Cell His
Mouse MXD3-5822M Recombinant Mouse MXD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MXD3-5822M-B Recombinant Mouse MXD3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mxd3-4232M Recombinant Mouse Mxd3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MXD3-3830R Recombinant Rat MXD3 Protein Mammalian Cell His
Rat MXD3-3489R Recombinant Rat MXD3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MXD3-3489R-B Recombinant Rat MXD3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MXD3-11283Z Recombinant Zebrafish MXD3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MXD3 Related Articles

MXD3 involved in several pathways and played different roles in them. We selected most pathways MXD3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MXD3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MXD3 has several biochemical functions, for example, DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MXD3 itself. We selected most functions MXD3 had, and list some proteins which have the same functions with MXD3. You can find most of the proteins on our site.

Function Related Protein
DNA bindingCEBPZ;LHX2B;ASCL5;HER4.2;FOXO1A;EME2;IFT57;HOXB5B;MCM9
protein bindingNIPAL1;RNF168;DYNLT3;SURF1;MED6;PAK3;SKP2;TMIGD2;RNPS1
protein dimerization activitySTK3;MESPBB;TCF21;ANO4;POLR2J2;GARS;SRFB;SIM1A;MESPBA

MXD3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MXD3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MXD3.

KRTAP10-7; NOTCH2NL; MAGEA11

Satake, N; Duong, C; et al. Novel Targeted Therapy for Precursor B Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugates. BLOOD 124:-(2014).
Satake, N; Duong, C; et al. Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia. BRITISH JOURNAL OF HAEMATOLOGY 167:487-499(2014).
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