myl3
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  • Official Full Name
  • myosin, light chain 3, alkali; ventricular, skeletal, slow
  • Background
  • MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
  • Synonyms
  • MYL3; myosin, light chain 3, alkali; ventricular, skeletal, slow; myosin, light polypeptide 3, alkali; ventricular, skeletal, slow; myosin light chain 3; CMH8; MLC1SB; MLC1V; VLC1; CMLC1; cardiac myosin light chain 1; ventricular/slow twitch myosin alkali
Cat.#:MYL3-5809HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL3 Protein, GST-tagged
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Cat.#:MYL3-1134HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL3, GST-tagged
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Cat.#:MYL3-8027HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL3 protein, His-tagged
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Cat.#:MYL3-10315MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYL3 Protein
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Cat.#:Myl3-8028MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Myl3 protein, His & GST-tagged
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Cat.#:MYL3-3855RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYL3 Protein
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Cat.#:MYL3-6715CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYL3
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Cat.#:MYL3-4027HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYL3 293 Cell Lysate
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Involved Pathway

MYL3 involved in several pathways and played different roles in them. We selected most pathways MYL3 participated on our site, such as Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cardiac muscle contraction
COX5B; SLC9A1; CACNG6A; CACNB4A; ATP1A3; ATP1B2A; UQCR11; TNNT2A; TPM4B; UQCRC2B
Adrenergic signaling in cardiomyocytes
CALM2B; RAPGEF3; GNAS; PIK3CA; MYH7; AGTR1; CACNG7; ATF2; PPP1CAB; ATP1A3B
Hypertrophic cardiomyopathy (HCM)
PRKAB2; IGF1; ITGA5; CACNG1; SGCG; CACNG8; ITGB5; TGFB3; ATP2A2; LMNA
Dilated cardiomyopathy
SLC8A1; ITGB8; TNNC1; CACNA2D3; DMD; CACNA2D2; ITGB1; ITGA1; TTN; GNAS

Protein Function

MYL3 has several biochemical functions, for example, actin monomer binding, calcium ion binding, motor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL3 itself. We selected most functions MYL3 had, and list some proteins which have the same functions with MYL3. You can find most of the proteins on our site.
Function
Related Protein
Function actin monomer binding
Related Protein LIMA1; PKNOX2; PFN2; MKL1; TMSB4Y; COBL; PRKCE; CORO1A; PFN4; TWF1
Function calcium ion binding
Related Protein EHD1; SYT4; CUBN; NELL2A; PCDH10A; CANT1B; CAPN3A; SMOC1; TNNC1B; LDLRA
Function motor activity
Related Protein MYO6B; MYHZ2; MYO15; DYNLRB1; MYH9A; SMYHC3; KIF5A; KIF3C; MYH1; MYO1G
Function myosin II heavy chain binding
Related Protein MYL4; MYL3
Function structural constituent of muscle
Related Protein MYOT; ANKRD2; CSRP3; MYBPC3; MYL5; MYL9; MYL1; TPM4; MYLPF; TTN

Interacting Protein

MYL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL3.
Mylk; FTH1; ATG101; YWHAZ