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MYLK2

  • Official Full Name

    myosin light chain kinase 2

  • Overview

    This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.
  • Synonyms

    MYLK2; myosin light chain kinase 2; myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle; KMLC; MLCK2; skeletal muscle myosin light chain kinase; skMLCK; MLCK;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MYLK2-1435H Active Recombinant Human MYLK2, His-tagged Sf9 Insect Cell His Full length
Human MYLK2-112HFL Active Recombinant Full Length Human MYLK2 Protein, C-His-tagged Sf21 His Full Length
Human MYLK2-1273H Recombinant Human Myosin Light Chain Kinase 2, GST-tagged Insect Cell GST
Human MYLK2-365H Recombinant Human Myosin Light Chain Kinase 2, His-tagged, Active Sf9 Insect Cell His
Human MYLK2-30269TH Recombinant Human MYLK2, His-tagged His
Human MYLK2-8030H Recombinant Human MYLK2 protein, His & T7-tagged E.coli His/T7 Ala313~Lys562 (Accession # Q9H1R3)
Human MYLK2-4016HCL Recombinant Human MYLK2 293 Cell Lysate HEK293 N/A
Human MYLK2-5824H Active Recombinant Human MYLK2 Protein, GST/His-tagged Insect Cell GST/His
Human MYLK2-8782HF Active Recombinant Full Length Human MYLK2 Protein, GST-tagged Insect (sf21) GST 1-596
Human MYLK2-5825H Recombinant Human MYLK2 Protein, GST-tagged Wheat Germ GST
Human MYLK2-6769HF Recombinant Full Length Human MYLK2 Protein, GST-tagged In Vitro Cell Free System GST 596 amino acids
Human MYLK2-1032H Recombinant Human MYLK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MYLK2-5222H Recombinant Human MYLK2 Protein (Ala313-Lys562), N-His tagged E.coli N-His Ala313-Lys562
Mouse Mylk2-8031M Recombinant Mouse Mylk2 protein, His & T7-tagged E.coli His/T7 Ala330~Ala548 (Accession # Q8VCR8)
Mouse Mylk2-4257M Recombinant Mouse Mylk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MYLK2-3858R Recombinant Rat MYLK2 Protein Mammalian Cell His
Rat Mylk2-8032R Recombinant Rat Mylk2 protein, His & T7-tagged E.coli His/T7 Ala327~Thr536 (Accession # P20689)
Rat MYLK2-3517R-B Recombinant Rat MYLK2 Protein Pre-coupled Magnetic Beads HEK293
Rat MYLK2-3517R Recombinant Rat MYLK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken MYLK2-6944C Recombinant Chicken MYLK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MYLK2 Related Articles

MYLK2 involved in several pathways and played different roles in them. We selected most pathways MYLK2 participated on our site, such as Calcium signaling pathway, Focal Adhesion, Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYLK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPHKA1;CAMK2B1;PPP3CCB;P2RX3;ERBB3;ADORA2AB;TRHRB;PTGER3;CAMK2D
Focal AdhesionCOL6A3;ITGB1;CAPN2A;SHC4;FYNB;TNR;COL24A1;RAP1B;PRKCBB
Gastric acid secretionCALML5;MYLK;Slc4a2;GAST;SLC9A1;CALML3;PLCB2;KCNJ1;GNAI3
Integrin-mediated cell adhesionCAPN5;CAPN11;MAPK6;SEPP1;SEPP1A;CAPN3A;CAPN3;CAPNS1;MYLK2
Myometrial Relaxation and Contraction PathwaysGABPA;RGS5;MYLK2;RAMP1;RGS11;IGFBP4;CORIN;ACTA1;ADM
Oxytocin signaling pathwayPPP3CA;CAMK4;PLCB3;CACNA2D1;HRAS;PIK3CG;PLCB2;NFATC1;ITPR1
Platelet activationPPP1R12A;P2RY1;PRKACG;MAPK11;GUCY1B3;PIK3R3;SNAP23;ROCK2;MYLK

MYLK2 has several biochemical functions, for example, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MYLK2 itself. We selected most functions MYLK2 had, and list some proteins which have the same functions with MYLK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNEK10;DDX51;ABCB5;ABCF1;STK26;PEX1;SYN3;RAF1B;ACTR2B
calmodulin bindingMYO5A;CAMK1GB;SNTB2;RYR2;PHKB;MKNK2B;ITPKA;EDF1;ADCY3
calmodulin-dependent protein kinase activityCAMKK1;CAMK2A;DAPK2A;MAPKAPK2B;CAMK1;CAMK2G1;MAPKAPK2;MAPKAPK2A;CAMKK2
myosin light chain kinase activityMYLK3;MYLK;MYLK2
protein bindingHLTF;TDRD9;SNAP91;EPB49;BIN1;PHF17;MCC;KCNE1;LRFN2

MYLK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYLK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYLK2.

ESR1; ESR2; MEF2C; NFKB2; HSP90AB1; TNFRSF1B; TRAF2; MAP3K1; MAP3K3; HSP90AA1

Wang, HG; Dong, JN; et al. Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis. IMMUNOLOGY 144:254-262(2015).
Gerarduzzi, C; He, QW; et al. Prostaglandin E-2-Dependent Blockade of Actomyosin and Stress Fibre Formation Is Mediated Through S1379 Phosphorylation of ROCK2. JOURNAL OF CELLULAR BIOCHEMISTRY 115:1516-1527(2014).
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