|Official Full Name||NCK adaptor protein 2|
|Background||This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.|
|Synonyms||NCK2; NCK adaptor protein 2; cytoplasmic protein NCK2; NCKbeta; SH2/SH3 adaptor protein NCK-beta; growth factor receptor-bound protein 4; noncatalytic region of tyrosine kinase, beta; GRB4|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
nck2 involved in several pathways and played different roles in them. We selected most pathways nck2 participated on our site, such as ErbB signaling pathway, Axon guidance, T cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with nck2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ErbB signaling pathway||AKT3A; NCK2B; MAPK10; RPS6KB1; PIK3R1; RAF1A; MAP2K4A; SHC4; MYCB; BTC|
|Axon guidance||EPHB3; SEMA5B; CNTN6; WDR83; FRS2A; RHOB; EPHA2A; SEMA6A; NEFLB; EPHB4|
|T cell receptor signaling pathway||BCL10; EVLB; NCK2; CD3D; MAP2K1; PIK3R2; LCP2; PAK6; NCK1; CBLB|
|Pathogenic Escherichia coli infection||CDH1; TUBB2B; FYN; NCK1; TUBA1C; TUBB; CD14; EZR; TUBA3D; KRT18|
nck2 has several biochemical functions, for example, SH3/SH2 adaptor activity, cytoskeletal adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by nck2 itself. We selected most functions nck2 had, and list some proteins which have the same functions with nck2. You can find most of the proteins on our site.
|SH3/SH2 adaptor activity||CNTNAP1; STAM; PAG1; SH2D3A; SKAP2; GRB10; SRC; GRB7; GAB1; TOB1|
|cytoskeletal adaptor activity||BAIAP2L1A; SDCBP; BAIAP2L1B; BAIAP2L2; BAIAP2L2B; BAIAP2; BAIAP2A; NCK1; BIN3; GAS2L1|
|protein binding||TCF4; TUFM; CBFA2T3; NELL1; PACSIN2; RPGRIP1L; MX2; RAD23B; TOP2A; S100A8|
|protein complex binding||C8G; CPD; IGBP1; CEBPA; HADHA; ABP1; HSPD1; NDUFA4; ANKRD54; PAFAH1B1|
|receptor signaling complex scaffold activity||AXIN1; SPAG9; GRIP1; MAPK8IP3; ROPN1B; SHANK1; G3BP2; MMS19; LDLRAP1; NUP62|
|scaffold protein binding||KRT8; SCN5A; NLGN4Y; SRC; PDE4D; DLG4; DSP; NLGN1; MAPK3; CASP8|
nck2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with nck2 here. Most of them are supplied by our site. Hope this information will be useful for your research of nck2.
RHOU; CHN1; PAK1; CBLB