NCOA2
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Official Full Name
nuclear receptor coactivator 2 -
Overview
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that genes transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010] -
Synonyms
NCOA2;nuclear receptor coactivator 2;SRC2;TIF2;GRIP1;KAT13C;NCoA-2;bHLHe75;hTIF2;transcriptional intermediary factor 2;class E basic helix-loop-helix protein 75;glucocorticoid receptor-interacting protein-1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NCOA2-3923R | Recombinant Rat NCOA2 Protein | Mammalian Cells | Rat | His |
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| NCOA2-9291Z | Recombinant Zebrafish NCOA2 | Mammalian Cells | Zebrafish | His |
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| NCOA2-3942HCL | Recombinant Human NCOA2 293 Cell Lysate | HEK293 | Human | Non |
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| NCOA2-23H | Recombinant Human NCOA2 Protein, N-His-tagged | E.coli | Human | His | Met1-Ile280 |
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| NCOA2-3581R | Recombinant Rat NCOA2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| NCOA2-3581R-B | Recombinant Rat NCOA2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
NCOA2 involved in several pathways and played different roles in them. We selected most pathways NCOA2 participated on our site, such as Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3,Activation of gene expression by SREBF (SREBP),Adipogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile acid and bile salt metabolism | SLCO1B1,Alb,AKR1C4,AKR1C21,CYP27A1,AKR1C2,CYP46A1,AKR1C6,SLC27A2,ACOT8 |
| Biological oxidations | SLC35D1A,CYP3A7-CYP3AP1,CYP2V1,CYP2J2,CYP7A1,NAT2,CYP2C18,CYP11B1,CYP1A1,GLYAT |
| Activation of gene expression by SREBF (SREBP) | NFYBB,HELZ2,PMVK,CARM1,CREBBP,NFYAL,SREBF2,MTF1,CYP51A1,DHCR7 |
| Chromatin modifying enzymes | PAX3A,CARM1,MORF4L2,AEBP2,ASH2L,PBRM1L,ATF7IP,TADA2B,KDM5D,KAT6B |
| Androgen receptor signaling pathway | KAT7B,KDM1A,PARK7,EFCAB6,CTNNB2,AES,MYST2,JUN,STUB1,RUNX2A |
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | KDM1A,KDM4C,HIST3H2BB,HIST2H3C,HIST4H4 |
| Adipogenesis | DLK1,CEBPD,HMGA1-RS1,SPOCK1,CNTFR,EBF1,KLF7,E2F1,KLF5,NR1H3 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | NAMPT,CRY2,CREBBP,CARM1,NRIP1,CRY1,HELZ2,DBP |
Protein Function
NCOA2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA2 itself. We selected most functions NCOA2 had, and list some proteins which have the same functions with NCOA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding | VAX1,VAX2,HSF1,HSF2,ZC3H8,SMYD3,ZNF350 |
| histone acetyltransferase activity | CLOCK,GTF3C4,MGEA5,EP300,ATF2,NCOA3,MED24,NCOA1,KAT7A,METTL8 |
| nuclear hormone receptor binding | MED1,MYOD1,ACTN4,BUD31,NCOR1,SIRT1,EP300,HIF1A,CTNNB1,SNW1 |
| protein dimerization activity | HER9,MYCN,SOHLH2,HES2.1,SCXA,MYO5A,TCF3A,DBI,CLOCKB,NPAS4 |
| protein binding | STX10,DCDC2,DNMT1,CUL3,PIP4K2B,FAM127C,TMED5,FAM156A,DNTTIP1,SIVA1 |
| transcription coactivator activity | ARID1A,NPM1,CALCOCO1,TAF5L,MAX,HINFP,MAML2,ZEB1,RXRB,FHL2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | PAX5,HOXC11,ARID3B,ZKSCAN3,POU1F1,HOXA2,SNAI3,FOXI1,CUX2,NFYC |
| ligand-dependent nuclear receptor binding | NCOA3,TRIM24,TADA3,JUND,NCOR1,NCOR2,SLC30A9,SMARCD3,MED1,TRIP4 |
| chromatin binding | HIST2H3C1,LHX2,AIRE,PCGF2,SP110,RERE,FLI1,ADNP,ACTL6A,SP140L |
Interacting Protein
NCOA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA2.
ESR1;AR;DDX17;DDX5;20-hydroxycholesterol;25-hydroxycholestero;(22r)-22-hydroxycholesterol;TP53;CTNNB1;TAF9
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References
- Dobroyolna, J; Chinenov, Y; et al. Glucocorticoid-Dependent Phosphorylation of the Transcriptional Coregulator GRIP1. MOLECULAR AND CELLULAR BIOLOGY 32:730-739(2012).
- Morzadec, C; Macoch, M; et al. Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone. FREE RADICAL BIOLOGY AND MEDICINE 71:133-145(2014).
