NDEL1

  • Official Full Name

    nudE nuclear distribution E homolog (A. nidulans)-like 1

  • Overview

    This gene encodes a thiol-activated peptidase that is phosphorylated in M phase of the cell cycle. Phosphorylation regulates the cell cycle-dependent distribution of this protein, with a fraction of the protein bound strongly to centrosomes in interphase and localized to mitotic spindles in early M phase. Overall, this protein plays a role in nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

  • Synonyms

    NDEL1;nudE nuclear distribution E homolog (A. nidulans)-like 1;nudE nuclear distribution gene E homolog (A. nidulans) like 1;nuclear distribution protein nudE-like 1;MITAP1;NUDEL;protein Nudel;endooligopeptidase A;mitosin-associated protein 1;mit

Recombinant Proteins

  • Mouse
  • Chicken
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • GST
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    NDEL1 involved in several pathways and played different roles in them. We selected most pathways NDEL1 participated on our site, such as Aurora A signaling,Cell Cycle,Cell Cycle, Mitotic, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDEL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    M Phase PDS5B,CENPN,CTDNEP1A,ITGB3BP,SETA,SGOL2,GORASP2,NEK9,MCPH1,NCAPH2
    Mitotic Metaphase and Anaphase SGOL1,CDCA8,CDCA5,NDEL1B,CENPK,VRK1,SPDL1,ZW10,CENPN,CCDC99
    Cell cycle CLSPN,UIMC1,NCAPD3,STAG1,WRAP53,CDC14B,MCM4,NSL1,UBE2V2,TUBG1
    Cell Cycle, Mitotic DCTN1,CENPO,BANF1,ZWINT,NCAPG2,SKA1,PCM1,DCTN1A,OFD1,CEP135
    Mitotic Prometaphase CDCA5,SPDL1,DSN1,RCC2,ZW10,KNTC1,MLF1IP,SPC25,SGOL2,NDEL1A
    Aurora A signaling TACC1,TDRD7,AURKB,GADD45A,TACC3,OAZ1,AURKAIP1,CENPA,TPX2
    Mitotic Anaphase CDCA5,CENPN,SPC24,INCENP,SPC25,NDEL1B,CENPH,NSL1,CENPC1,CENPL
    Lissencephaly gene (LIS1) in neuronal migration and development VLDLR,DYNLT1,DAB1,KATNA1,DCX,MAP1B,NUDC,LRPAP1

    Protein Function

    NDEL1 has several biochemical functions, for example, alpha-tubulin binding,beta-tubulin binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDEL1 itself. We selected most functions NDEL1 had, and list some proteins which have the same functions with NDEL1. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding SERPINB1A,KIF12,BCL2L11,MTAP7D3,TUBGCP5,LC3,KIF20A,CRIPT,TXNDC3,NDE1
    alpha-tubulin binding BBS4,SNCA,C9orf24,HDAC6,ARL4C,CAV3,WASH1,ARL8A,PROL1,INO80
    beta-tubulin binding BBS4,GABARAP,SERPINB1A,EMD,GABARAPL2,B4GALT1,FGF13,CASC1,PEX14,PDCD5
    protein binding BRPF1,DMC1,PTTG1,P2RX4,EIF2B2,AHSP,MAPK11,PRMT1,RTF1,CYB561

    Interacting Protein

    NDEL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDEL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDEL1.

    CENPF;DISC1;TRIM27

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