Ndufa4
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Official Full Name
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rhesus macaque
- Chicken
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
Ndufa4 involved in several pathways and played different roles in them. We selected most pathways Ndufa4 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with Ndufa4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | UQCRQ,COX7B2,SDHB,NDUFV3,PRKAA2,NDUFA12,NDUFA4L2,CYCS,NDUFV1,PIK3R3 |
| Alzheimers disease | PLCB2,UQCR10,NDUFAB1,BACE2,LRP1,BACE1,NDUFA4L2,CASP9,GRIN2B,AKR1C1 |
| Parkinsons disease | NDUFS2,GNAI1,NDUFB1,NDUFA8,NDUFB8,NDUFA9,UQCRH,NDUFS8,UQCRC1,TH |
| Oxidative phosphorylation | SDHD,NDUFA9A,NDUFS8A,ATP5D,COX11,MT-ND1,COX5A,NDUFC1,ATP6V0A4,UQCRH |
| Metabolic pathways | ASAH2,ST6GAL2,CYP3A65,NT5C2B,PAPSS2A,LIPT1,ALDH3B1,B4GALT3,ACACA,NDUFA7 |
| Huntingtons disease | ATP5J,NDUFB1,DCTN4,NDUFB6,ATP5B,Casp3,PLCB3,SLC25A4,DNAL4,COX7C |
Protein Function
Ndufa4 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity,contributes_to cytochrome-c oxidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ndufa4 itself. We selected most functions Ndufa4 had, and list some proteins which have the same functions with Ndufa4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NADH dehydrogenase (ubiquinone) activity | NDUFB6,NDUFS8,NDUFA7,NDUFA1,NDUFA9,NDUFS2,NDUFAF2,NDUFB10,NDUFB8,NDUFA2 |
| protein complex binding | SLC27A5,AP2A1,FYB,Casp3,C8B,TUBB,ING2,LEPRE1,GNB4,CYFIP1 |
| protein binding | SNX6,VASH1,CDK5R2,SMARCAD1,PPP1R16B,SOX4,UNKL,NUDCD3,FANCB,GCKR |
| contributes_to cytochrome-c oxidase activity | COX10,COX15 |
Interacting Protein
Ndufa4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ndufa4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ndufa4.
PARP2;NDUFA2;TSC22D1;WRAP73;GABARAP;EGFR;ERBB2;PHKG2;NDUFA6;Tubg1;ILK;CLPP;P;CDK15;Kat8;GABARAPL1;MAP1LC3A;NDUFA12
Resources
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References
- Vuillaume, ML; Naudion, S; et al. New Candidate Loci Identified By Array-CGH in a Cohort of 100 Children Presenting With Syndromic Obesity. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1965-1975(2014).
- Pitceathly, RDS; Taanman, JW; et al. COX10 Mutations Resulting in Complex Multisystem Mitochondrial Disease That Remains Stable Into Adulthood. JAMA NEUROLOGY 70:1556-1561(2013).
