ndufv1 Protein, NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa


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Official Full Name NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
Background The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinsons disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; NADH dehydrogenase (ubiquinone) flavoprotein 1 (51kD); NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; CI 51K; complex I 51kDa subunit; NADH dehydrogenase [ubiquinone] flavoprotein 1; mitochondrial; CI 51kD; CI-51kD; Complex I 51kD; Complex I-51kD; FLJ59059; NADH dehydrogenase (ubiquinone) flavoprotein 1; NADH dehydrogenase flavoprotein 1; NADH ubiquinone oxidoreductase 51 kDa subunit; NADH ubiquinone oxidoreductase; NADH-ubiquinone oxidoreductase 51 kDa subunit; NDUFV 1; NDUV1_HUMAN; UQOR1; OTTHUMP00000232178; OTTHUMP00000232181; OTTHUMP00000232183; OTTHUMP00000232187; complex I 51 kda subunit; complex I, mitochondrial respiratory chain; NADH-ubiquinone oxidoredu; CI-51K; CI51KD
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NDUFV1-2770H Recombinant Human NDUFV1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human NDUFV1-1180HCL Recombinant Human NDUFV1 cell lysate N/A
    Human NDUFV1-1243H Recombinant Human NDUFV1, GST-tagged E.coli GST
    Human NDUFV1-29479TH Recombinant Human NDUFV1 Wheat Germ N/A
    Mouse NDUFV1-10548M Recombinant Mouse NDUFV1 Protein Mammalian Cell His
    Cynomolgus Monkey NDUFV1-741C Recombinant Cynomolgus NDUFV1 Protein, His-tagged Mammalian Cell His
    Chicken NDUFV1-3224C Recombinant Chicken NDUFV1 Mammalian Cell His
    Zebrafish NDUFV1-1086Z Recombinant Zebrafish NDUFV1 Mammalian Cell His

    ndufv1 involved in several pathways and played different roles in them. We selected most pathways ndufv1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with ndufv1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation ATP5J2; UQCRC2; COX4I2; MT-ND1; ATP5I; NDUFB10; NDUFC2-KCTD14; UQCRFS1; ATP6V0E2; UQCRC1
    Metabolic pathways GATM; PIP5KL1; POLR2J; HMGCS2; DLDH; PCYT2; HIBADHB; Aldh1a7; FECH; HAO1
    Non-alcoholic fatty liver disease (NAFLD) IRS2; UQCRC1; NDUFA3; FASLG; NDUFB6; RXRA; PIK3CG; GSK3B; NDUFB9; SDHA
    Alzheimers disease COX7A2L; NDUFAB1; ATP5H; COX8C; ITPR3; ATP5O; NDUFC1; PSEN1; APH1C; FADD
    Parkinsons disease HTRA2; VDAC2; VDAC1; NDUFB9; NDUFA4L2; CASP9; GNAI2; MT-ATP6; NDUFB7; COX7B
    Huntingtons disease POLR2F; PPIF; SLC25A31; DNAHC8; COX7C; NDUFS4; PLCB4; ATP5C1; DNAIC2; NDUFS1

    ndufv1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, contributes_to FMN binding, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ndufv1 itself. We selected most functions ndufv1 had, and list some proteins which have the same functions with ndufv1. You can find most of the proteins on our site.

    Function Related Protein
    4 iron, 4 sulfur cluster binding NUBP1; ETFDH; CDKAL1; DDX11; RTEL1; ERCC2; POLD1; TYW1; MOCS1; NDUFS7
    contributes_to FMN binding NDUFV1
    NAD binding IDH3G; GPD1; CTBP2A; HSD17B10; AOX4; IDH2; ADH4; LDHA; NDUFV1; BDH2
    NADH dehydrogenase (ubiquinone) activity NDUFB7; NDUFA9; NDUFV2; NDUFA4; NDUFA3; NDUFB10; NDUFS3; NDUFB5; NDUFAB1; NDUFAF2
    contributes_to NADH dehydrogenase activity NDUFS2; NDUFV1; NDUFS7; NDUFS8
    metal ion binding FHL3B; KLF11; AGMAT; CLCNKA; CSRP1B; CYP1C2; TRIM55B; CSHL1; ZSCAN1; ZNF547

    ndufv1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ndufv1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ndufv1.


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