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Official Full Name neuropilin (NRP) and tolloid (TLL)-like 2
Background This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms NETO2; neuropilin (NRP) and tolloid (TLL)-like 2; neuropilin and tolloid-like protein 2; FLJ10430; NEOT2; BTCL2; FLJ14724; FLJ90456; Brain specific transmembrane protein; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; NETO 2; NETO2_HUMAN; Neuropilin (NRP) and tolloid (TLL) like 2; Neuropilin and tolloid like protein 2
    • Type:
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NETO2-1265H Recombinant Human NETO2, GST-tagged E.coli GST
    Human NETO2-3872HCL Recombinant Human NETO2 293 Cell Lysate HEK293 N/A
    Mouse NETO2-10589M Recombinant Mouse NETO2 Protein Mammalian Cell His
    Rat NETO2-3960R Recombinant Rat NETO2 Protein Mammalian Cell His
    Rhesus Macaque NETO2-3004R Recombinant Rhesus monkey NETO2 Protein, His-tagged Mammalian Cell His

    neto2 involved in several pathways and played different roles in them. We selected most pathways neto2 participated on our site, such as ARMS-mediated activation, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with neto2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation PAQR3A; SPTBN1; PSMD9; AKAP9; FGF10B; NETO2; SPTBN2; FGF8B; SPNA1; DUSP6
    Activation of NMDA receptor upon glutamate binding and postsynaptic events DLG4; NETO2; AKAP9; SLC14A2; CREB1; ADCY8; CAMKK1B; ADCY1; PDPK1A; ADCY3
    Adrenergic signaling in cardiomyocytes PPP2R5C; ADCY3; PPP2R1B; MYL4; CACNG1A; CACNA2D1A; ADRB1; PRKACAB; ADCY9; CREB1A
    Aldosterone synthesis and secretion CAMK1; PRKD1; LIPE; PDE2A; CAMK2D; CREB3L2; CALML3; HSD3B6; CAMK1D; PLCB3
    Amphetamine addiction SLC6A3; CALM4; PRKACB; DRD1A; CREB3L2; CREB3L1; CREB3L4; PRKACA; SLC18A1; PRKACG
    Axon guidance PAQR3A; GSK3B; AP2M1; DUSP10; DUSP4; EPHA3; CAP1; ABLIM2; COL6A2; MET
    BCR signaling pathway DOK1; CSK; NETO2; PAG1; MAP4K1; CSNK2A1; POU2F2; IBTK; MALT1
    CREB phosphorylation through the activation of CaMKII CREB1B; DLG4; AKAP9; NETO2; SLC14A2; NEFLB

    neto2 has several biochemical functions, for example, ATP binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by neto2 itself. We selected most functions neto2 had, and list some proteins which have the same functions with neto2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAP3K11; FLT3; CKBB; ACOT12; ATP1A4; SLC27A2; TOP2B; ALK; MAP3K14; VARS
    calcium-dependent protein serine/threonine phosphatase activity NETO2; PPP3R1; PPP3CB; CAMK2G
    calmodulin binding CNGA2; EPB41; CAMKV; CAMK2D2; EEF2K; DAPK2; MYO1A; RYR3; TRPM4; VAMP2
    calmodulin-dependent protein kinase activity MAPKAPK2; MAPKAPK2A; CAMK2D1; CAMK1D; MYLK3; SLC14A2; CAMKK2; NETO2; MKNK1; PTK2B
    protein binding C1QTNF8; WSB1; LTBR; PPP1R7; TTC8; RG9MTD1; KXD1; LACE1; BIN2; PSMD5
    protein homodimerization activity PLD6; DMRT3A; HRSP12; TERT; MAPK4; LMLN; GRM6; NACC2; PON3; CBX1

    neto2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with neto2 here. Most of them are supplied by our site. Hope this information will be useful for your research of neto2.

    ytpB; TIA1; WDHD1; KRT17; AIMP2; NELFCD; CCDC82; HS6ST2; TMEM168; TRMT6; IRS2

    Lindstrom, SH; Ryan, DG; et al. Kainate receptor subunit diversity underlying response diversity in retinal Off bipolar cells. JOURNAL OF PHYSIOLOGY-LONDON 592:1457-1477(2014).
    Zhang, W; Devi, SPS; et al. Auxiliary proteins promote modal gating of AMPA- and kainate-type glutamate receptors. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1138-1147(2014).

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