NGFR
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Official Full Name
nerve growth factor receptor
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Overview
receptor that can bind NGF, BDNF, NT-3, and NT-4 [RGD, Feb 2006] -
Synonyms
NGFR; nerve growth factor receptor; p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16; tumor necrosis factor receptor superfamily member 16; p75 ICD; gp80-LNGFR; NGF receptor; nerve growth factor receptor, fast; low affinity nerve growth factor receptor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16);
- Recombinant Proteins
- Cell & Tissue Lysates
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- Fc
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- hIgG4
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- Interacting Protein
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- NGFR Related Signal Pathway
NGFR involved in several pathways and played different roles in them. We selected most pathways NGFR participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NGFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | RHOA;HGF;MAPK3;SHOC2;PAK3;FGF11;PLCG2;Fgf15;PLCE1 |
| Rap signaling pathway | PIK3R3;INS1;FLT4;ITGB2;MAP2K1;MAGI1;RAPGEF6;PLCB3;HGF |
| Cytokine-cytokine receptor interaction | IL13;EDA;TNFSF9;FAS;CCR10;MET;PPBP;CXCL5;IL23 |
| PIK-Akt signaling pathway | VEGFB;TNC;IFNA16;PTEN;PIK3R5;LAMB2;ITGA2;PTK2;MAP2K1 |
| Neurotrophin signaling pathway | IRAK4;BCL2;SORT1;ATF4;MAPK13;CAMK2A;RAPGEF1;AKT1;TP53 |
| Transcriptional misregulation in cancer | RUNX1;IL6;MEN1;TSPAN7;HIST2H3A;KLF3;NFKB1;HIST1H3E;EWSR1 |
NGFR has several biochemical functions, for example, Rab GTPase binding, beta-amyloid binding, death receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NGFR itself. We selected most functions NGFR had, and list some proteins which have the same functions with NGFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab GTPase binding | RABGAP1L;MLPH;RAB11FIP3;ANKRD27;RAB8A;CCDC64;LLGL2;SYTL3;ALS2 |
| beta-amyloid binding | HSD17B10;TGFB2;LDLRAP1;COL25A1;TSSK1B;BACE1;ARMCX5-GPRASP2;LDLRAD3;APOE |
| death receptor activity | NGFR;TNFRSF10A |
| nerve growth factor binding | NTRK1;SORT1;PCSK6;NGFR;NGFRB;FURIN |
| neurotrophin TRKA receptor binding | NGFR;EFNA5;PIK3R1;FRS2;PLCG1;SHC1;GRB2 |
| neurotrophin binding | NGFR;NTRK1;NTRK3;NTRK2 |
| preprotein binding | |
| protein binding | PBK;DYNLT1;SCNN1B;SOX9A;NMI;CRYBA4;NAPA;PSMD3;B4GALT7 |
| tumor necrosis factor-activated receptor activity | TNFRSF8;TNFRSF10C;NGFRB;NGFR;LTBR;FAS;NRADD;TNFRSF19;TNFRSF1B |
| ubiquitin protein ligase binding | YWHAZ;MC1R;TRAF1;CUL1;PACRG;TRAF6;SUMO2;UBE2J1;RANGAP1 |
NGFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NGFR here. Most of them are supplied by our site. Hope this information will be useful for your research of NGFR.
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Customer Reviews (3)
Write a reviewIts usage in ELISA and protein electron microscopy structure analysis has been reported to yield highly reproducible and interpretable results, providing valuable insights into the molecular mechanisms and biological processes under investigation.
Its excellent performance in ELISA assays makes it a valuable tool in quantifying analytes in biological samples.
Its reliability, specificity, and versatility make it an invaluable asset in studying and understanding complex biological systems.
Q&As (5)
Ask a questionNGFR protein is involved in the survival and maintenance of nerve cells, and its dysregulation has been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease.
Research into NGFR protein as a potential target for the development of novel pain therapies is ongoing, with the aim of modulating pain signaling pathways.
Some studies have explored the potential of NGFR protein as a therapeutic target for neurodegenerative diseases, with the aim of promoting nerve cell survival and function.
Research suggests that alterations in NGFR protein levels may serve as a potential biomarker for neurodegenerative diseases, aiding in early diagnosis and monitoring disease progression.
NGFR protein is being investigated for its potential role in promoting nerve regeneration after injury, with the aim of developing new treatments for nerve damage and paralysis.
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