Active Recombinant Human NGFR Protein

• Cat.No.: NGFR-169N
• Product Overview: Recombinant Human NGFR Protein without tag was expressed in HEK 293.

Specification

• Description: NGF Receptor, also known as Gp80-LNGFR, p75 ICD, CD271 and TNFRSF16, is a type I transmembrane protein belonging to the TNF receptor family. It is expressed by both neuronal and non-neuronal cells. Signaling through NGF Receptor has been shown to regulate gene expression, cell migration and death. A truncated NGF Receptor containing only the extracellular domain has been detected in plasma, amniotic fluid and urine, and acts as a potent NGF antagonist.
• Source: HEK 293
• Species: Human
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 0.4 μg/mL, measured in a neutrolization assay using TF-1 cells in the presence of 10 ng/mL human b-NGF.
• Molecular Mass: 32-60 kDa, observed by reducing SDS-PAGE.
• AA Sequence: KEACPTGLYTHSGECCKACNLGEGV AQPCGANQTVCEPCLDSVTFSDVVS ATEPCKPCTECVGLQSMSAPCVEAD DAVCRCAYGYYQDETTGRCEACRVC EAGSGLVFSCQDKQNTVCEECPDGT YSDEANHVDPCLPCTVCEDTERQLR ECTRWADAECEEIPGRWITRSTPPE GSDSTAPSTQEPEAPPEQDLIASTV AGVVTTVMGSSQPVVTRGTTDN
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant human NGF Receptor remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human NGF Receptor should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: NGFR nerve growth factor receptor [ Homo sapiens ]
• Official Symbol: NGFR
• Synonyms: NGFR; nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16; CD271; low affinity nerve growth factor receptor; p75NTR; TNFR superfamily; member 16; TNFRSF16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; p75(NTR); Gp80-LNGFR
• Gene ID: 4804
• mRNA Refseq: NM_002507
• Protein Refseq: NP_002498
• MIM: 162010
• UniProt ID: P08138