SLC9A1
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Official Full Name
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
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Overview
SLC9A1 (NHE1), a member of the Na+/H+ exchanger family, is a ubiquitous membrane protein that regulates intracellular pH and cell volume. Furthermore, SLC9A1 is known to interact with the actin cytoskeleton. Fibroblasts expressing mutated NHE1 that fails -
Synonyms
SLC9A1; solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1; APNH, NHE1, solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) , solute carrier family 9 (sodium/hydrogen ex;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Zebrafish
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | SLC9A1-1695HCL | Recombinant Human SLC9A1 293 Cell Lysate | HEK293 | N/A |
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| Rat | SLC9A1-5584R | Recombinant Rat SLC9A1 Protein | Mammalian Cell | His |
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| Rat | SLC9A1-5243R | Recombinant Rat SLC9A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | SLC9A1-5243R-B | Recombinant Rat SLC9A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | SLC9A1-6293Z | Recombinant Zebrafish SLC9A1 | Mammalian Cell | His |
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| Chicken | SLC9A1-3435C | Recombinant Chicken SLC9A1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
SLC9A1 involved in several pathways and played different roles in them. We selected most pathways SLC9A1 participated on our site, such as cAMP signaling pathway, Cardiac muscle contraction, Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | ORAI1;NFKBIA;GNAI2;HTR4;ROCK1;PRKACG;PIK3R5;MLLT4;GRIN2B |
| Cardiac muscle contraction | TNNC1B;ATP1A2A;COX8C;CACNG6A;UQCRC2A;CACNG8;TNNC1;ATP1B1B;RYR2 |
| Adrenergic signaling in cardiomyocytes | PPP2CA;FXYD2;TNNC1B;PPP2R5EA;MAPK3;CACNG1A;PPP2R5D;MAPK11;CREB3L3A |
| Regulation of actin cytoskeleton | FGF6B;RHOA;ABI2;FGFR1;FGF8A;RAC3;PIP4K2B;MYH10;MRAS |
| Thyroid hormone signaling pathway | DIO1;FXYD2;ATP1A1;MED17;PLCD1;PIK3R1;ATP1B2;NRAS;ATP2A2 |
| Salivary secretion | NOS1;PLCB1;ITPR3;ITPR1;LYZ1;PRKG2;PRH2;AQP5;CST4 |
| Gastric acid secretion | ACTB;MYLK;CALM3;PRKACB;GNAI2;PLCB1;KCNQ1;Adcy4;KCNJ15 |
| Pancreatic secretion | RAP1B;KCNMA1;PLCB2;GNAS;CA2;ATP2A3;PLA2G1B;CCKAR;PRSS1 |
| Bile secretion | FAM84B;ATP1A1;NCEH1;AQP4;GNAS;ATP1B4;ATP1A2;AQP1;CYP3A4 |
| Proteoglycans in cancer | ERBB2;ITGA2;FLNC;CAV1;ITGAV;CTTN;ROCK2;RPS6;WNT4 |
SLC9A1 has several biochemical functions, for example, calcium-dependent protein binding, calmodulin binding, phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A1 itself. We selected most functions SLC9A1 had, and list some proteins which have the same functions with SLC9A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent protein binding | DMBT1;ANXA2;STMN2;PDCD6IP;A2M;C9orf9;MMP13;VAMP2;CCDC167 |
| calmodulin binding | PDE1C;MYO1D;PDE1A;EEA1;AKAP5;OBSCN;MKNK1;SLC9A1;ARPP21 |
| phosphatidylinositol-4,5-bisphosphate binding | PARD3;FAM21C;KLHL8;FAM123B;TWF1;ALOX15;STXBP6;LDLRAP1;TTPA |
| protein binding | DCUN1D1;IGHM;ATP1B1;TTC12;PAEP;RPS6KA4;ARL14;SMARCA2;ITGAM |
| protein binding, bridging | PPP4R2;CAV2;CNTLN;TRIM5;TJP2;NMD3;WWC1;NEFL;FLRT3 |
| protein complex scaffold | AKAP13;CAV1;SLC9A3R1;AXIN1;WWC3;CHCHD3;TELO2;MAGI1B;ITSN1 |
| protein phosphatase 2B binding | ATP2B4;SLC9A1;PPP3CB;MYOZ2;AKAP5;SOD1;BAD;AKAP1 |
| sodium:proton antiporter activity | SLC9A5;SLC9A6B;SLC9A3.2;SLC9A1;SLC9A7;SLC9A6A;SLC9A8;SLC9A3.1;SLC9A9 |
| sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential | |
| solute:proton antiporter activity | SLC9A5;SLC9A10;SLC9A6B;SLC9A3.2;SLC9A9;NHEDC1;SLC9A3.1;SLC9A4;TMCO3 |
SLC9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A1.
YWHAB; MAP3K7; CHP2; MAP4K4; UBE2I; MDFI; Rab5c; YWHAZ; Gbf1; Taf15; AP4S1; Mad2l1
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