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NLRC5

Official Full Name

NLR family, CARD domain containing 5
Overview

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways.
Synonyms

NLRC5; NLR family, CARD domain containing 5; protein NLRC5; CLR16.1; FLJ21709; NOD like receptor C5; NOD27; nucleotide binding oligomerization domain; leucine rich repeat and CARD domain containing 5; Caterpiller protein 16.1; FLJ39711; NLRC5_HUMAN; NOD-like receptor C5; NOD4; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; OTTHUMP00000164675; Protein Caterpiller 16.1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc|DDK

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	NLRC5-489H	Recombinant Human NLRC5 protein, His-tagged	HEK293	His	Inquiry
Human	NLRC5-1078H	Recombinant Human NLRC5	Mammalian Cell	His	Inquiry
Human	NLRC5-45HCL	Recombinant Human NLRC5 Over-expression cell lysate	HEK293T	Myc/DDK	Inquiry
Human	NLRC5-3640H	Recombinant Human NLRC5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Human	NLRC5-3640H-B	Recombinant Human NLRC5 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	NLRC5-10715M	Recombinant Mouse NLRC5 Protein	Mammalian Cell	His	Inquiry
Mouse	NLRC5-6094M-B	Recombinant Mouse NLRC5 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	NLRC5-6094M	Recombinant Mouse NLRC5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
NLRC5 Related Articles

NLRC5 involved in several pathways and played different roles in them. We selected most pathways NLRC5 participated on our site, such as Immune System, Innate Immune System, Negative regulators of RIG-I/MDA5 signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with NLRC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Immune System	IRF6;LILRB4;LGALS9;STUB1;PANX1;SRMS;BTR18;NLRP3;CTS7
Innate Immune System	PANX1B;RIPK3;BTR12;POLR3F;TLR10;CTSLL;POLR3G;CRCP;RCA2.1
Negative regulators of RIG-I/MDA5 signaling	RNF216;TAX1BP1B;TAX1BP1;PCBP2;NLRC5;RNF135;CYLD;HERC5
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	TAX1BP1;NLRC5;RNF216;RNF135;PCBP2;TANK;HERC5;TAX1BP1B

NLRC5 has several biochemical functions, for example, ATP binding, RNA polymerase II core promoter sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NLRC5 itself. We selected most functions NLRC5 had, and list some proteins which have the same functions with NLRC5. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	SPS2;PASK;DGKB;DDX27;AK3;UBE2W;GUCY2E;PPIP5K2;KLHL8
RNA polymerase II core promoter sequence-specific DNA binding	EP300;SOX11;SUZ12;ZFPM1;SOX3;H3F3B;HNF4A;RUVBL2;RBPJ
protein binding	WBSCR27;ISYNA1;MMP20;JOSD1;C1orf105;POU3F3;DR1;ADRB1;EIF3A

NLRC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NLRC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of NLRC5.

Gultekin, Y; Eren, E; et al. Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein. JOURNAL OF INNATE IMMUNITY 7:25-36(2015).

Wybranska, I; Polus, A; et al. Apoptosis-related gene expression in glioblastoma (LN-18) and medulloblastoma (Daoy) cell lines. HUMAN CELL 26:137-148(2013).