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Official Full Name nucleoporin 133kDa
Background The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells.
Synonyms NUP133; nucleoporin 133kDa; nucleoporin 133kD; nuclear pore complex protein Nup133; FLJ10814; 133 kDa nucleoporin; hNUP 133; hNUP133; MGC21133; NU133_HUMAN; Nucleoporin NUP133; NUP 133; OTTHUMP00000061095
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NUP133-1413H Recombinant Human NUP133, GST-tagged E.coli GST
    Human NUP133-1542H Recombinant Human NUP133 protein, His & T7-tagged E.coli His/T7
    Human NUP133-3633HCL Recombinant Human NUP133 293 Cell Lysate HEK293 N/A
    Mouse Nup133-1543M Recombinant Mouse Nup133 protein, His & T7-tagged E.coli His/T7
    Zebrafish NUP133-12689Z Recombinant Zebrafish NUP133 Mammalian Cell His

    nup133 involved in several pathways and played different roles in them. We selected most pathways nup133 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with nup133 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RNA transport EIF3HA; TGS1; THOC2; EIF3JA; UPF3A; EIF3A; NUP160; NCBP2; SUMO3B; THOC1

    nup133 has several biochemical functions, for example, nucleocytoplasmic transporter activity, protein binding, structural constituent of nuclear pore. Some of the functions are cooperated with other proteins, some of the functions could acted by nup133 itself. We selected most functions nup133 had, and list some proteins which have the same functions with nup133. You can find most of the proteins on our site.

    Function Related Protein
    nucleocytoplasmic transporter activity NUP214; NUP107; UPF3A; NUP133; NUP153; RBM22; NUP160; TPR; XPO1; NUPL1
    protein binding ANP32B; RAN; GP1BB; ZNF329; TPI1; TRAF7; ZNF238; METTL17; HPRT1; CNTNAP2
    structural constituent of nuclear pore NUP62; NUP93; NUP133; NUP155; NUP107; NDC1; NUP153; NUP205; TMEM33; NUP62L

    nup133 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with nup133 here. Most of them are supplied by our site. Hope this information will be useful for your research of nup133.

    NUP107; LRRK2; MYC; Nup98; Nup107; NUP153; AHCTF1

    Dawson, TR; Lazarus, MD; et al. ER membrane-bending proteins are necessary for de novo nuclear pore formation. JOURNAL OF CELL BIOLOGY 184:659-675(2009).
    Harel, A; Orjalo, AV; et al. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. MOLECULAR CELL 11:853-864(2003).

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