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OAS3

Official Full Name

2-5-oligoadenylate synthetase 3, 100kDa
Overview

This gene encodes an enzyme included in the 2, 5 oligoadenylate synthase family.This enzyme is induced by interferons and catalyzes the 2, 5 oligomers of adenosine in order to bind and activate RNase L.This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
Synonyms

OAS3; 2-5-oligoadenylate synthetase 3, 100kDa; 2 5 oligoadenylate synthetase 3 (100 kD); 2-5-oligoadenylate synthase 3; p100OAS; p100 OAS; 2-5A synthase 3; 2-5A synthetase 3; (2-5)oligo(A) synthase 3; (2-5)oligo(A) synthetase 3; 2-5oligoadenylate syntheta;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	OAS3-1434H	Recombinant Human OAS3, GST-tagged	E.coli	GST	1-350aa	$319 / 25ug
Human	OAS3-3613HCL	Recombinant Human OAS3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	OAS3-3742H	Recombinant Human OAS3 protein, His-tagged	E.coli	His	1-350 aa	$319 / 25ug
Mouse	OAS3-11043M	Recombinant Mouse OAS3 Protein	Mammalian Cell	His		Inquiry
Mouse	OAS3-6296M-B	Recombinant Mouse OAS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	OAS3-6296M	Recombinant Mouse OAS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	OAS3-4145R	Recombinant Rat OAS3 Protein	Mammalian Cell	His		Inquiry
Rat	OAS3-3807R	Recombinant Rat OAS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	OAS3-3807R-B	Recombinant Rat OAS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

OAS3 involved in several pathways and played different roles in them. We selected most pathways OAS3 participated on our site, such as Hepatitis C, Measles, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Hepatitis C	CLDN14;TYK2;CLDN18;ARAF;IFNA2;NRAS;PIK3CG;PDPK1;EIF3E
Measles	IFNA6;CD3G;IRAK4;HSPA1B;TYK2;Ifna15;HSPA1A;CCNE2;AKT1
Influenza A	NFKB1;IFNA14;TLR7;IL8L2;TNFRSF10B;MAPK12;BLB1;Ifna11;IFNAR1
Herpes simplex infection	HLA-DMB;Hc;IFNA17;CYCS;TP53;PVRL1B;HCFC2;HLA-DMA;IFIH1

OAS3 has several biochemical functions, for example, 2-5-oligoadenylate synthetase activity, ATP binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAS3 itself. We selected most functions OAS3 had, and list some proteins which have the same functions with OAS3. You can find most of the proteins on our site.

Function	Related Protein
2-5-oligoadenylate synthetase activity	OAS1;OAS1A;OASL2;OAS2;OAS3
ATP binding	UBE2N;TEC;DHX29;ZNF143B;CIT;KIF6;NOLC1;DDX39;GK
double-stranded RNA binding	DICER1;STAU1;OAS1;STAU2;DHX30;MBNL1;ILF2;TUBB4B;TFRC
metal ion binding	ADAM1B;ZNF69;CBS;ZFP639;CYP17A2;ZFP516;RNF144AB;BCL11AB;ZFP428
protein binding	KLK6;HYAL3;SSX3;EFNA3;GPATCH4;MAFB;SMN1;TRIM38;HTR1B

OAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAS3.

EIF6; IFRD2; DHX30; MAVS; FTSJ3; PPM1G; CCDC22; TOP1; HIST1H1C; PABPC4; Eea1; ZNF622; GNL3; GTPBP4; LYAR