OGN

  • Official Full Name

    osteoglycin

  • Overview

    Osteoglycin(also Mimecan), encoded by the OGN gene is a human protein. This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.
  • Synonyms

    OGN; osteoglycin; OG; OIF; SLRR3A; DKFZp586P2421; osteoglycin (osteoinductive factor); mimecan; mimecan proteoglycan; Osteoinductive factor; OTTHUMP00000021650; OTTHUMP00000021651; OTTHUMP00000063691; corneal keratan sulfate proteoglycan;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human OGN-914H Recombinant Human OGN, His-tagged E.coli His
Human OGN-3590HCL Recombinant Human OGN 293 Cell Lysate HEK293 N/A
Human OGN-3591HCL Recombinant Human OGN 293 Cell Lysate HEK293 N/A
Human OGN-4765H Recombinant Human OGN Protein (Leu180-Phe298), N-His tagged E.coli N-His Leu180-Phe298
Human OGN-1575H-B Recombinant Human OGN Protein Pre-coupled Magnetic Beads HEK293
Human OGN-577H Recombinant Human OGN Protein (Met1-Phe298), His-tagged HEK293 His Met1-Phe298
Human OGN-1477H Recombinant Human OGN Protein (21-298 aa), His-tagged Yeast His 21-298 aa
Human OGN-1584H Recombinant Human OGN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human OGN-1575H Recombinant Human OGN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human OGN-1673H Recombinant Human OGN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human OGN-3304H Recombinant Human OGN protein, His-tagged E.coli His 21-298aa
Human OGN-741HFL Recombinant Full Length Human OGN Protein, C-Flag-tagged Mammalian cells Flag
Mouse Ogn-7997M Recombinant Mouse Ogn protein, His-tagged E.coli His Leu180~Phe298 (Accession # Q62000)
Mouse Ogn-4584M Recombinant Mouse Ogn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Ogn-7998R Recombinant Rat Ogn protein, His-tagged E.coli His Leu180~Phe298 (Accession # D3ZVB7)
Rhesus Macaque OGN-3160R Recombinant Rhesus monkey OGN Protein, His-tagged Mammalian Cell His
Rhesus Macaque OGN-2978R Recombinant Rhesus Macaque OGN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque OGN-2978R-B Recombinant Rhesus Macaque OGN Protein Pre-coupled Magnetic Beads HEK293
Zebrafish OGN-2223Z Recombinant Zebrafish OGN Mammalian Cell His
Chicken OGN-5783C Recombinant Chicken OGN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

OGN involved in several pathways and played different roles in them. We selected most pathways OGN participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with OGN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)ACAN;FMOD;PRELP;KERA;OGN
Defective CHST6 causes MCDC1OGN;PRELP;ACAN;KERA;FMOD
Defective ST3GAL3 causes MCT12 and EIEE15ACAN;OGN;PRELP;KERA;FMOD
DiseaseRLBP1;CPSF6;HEY1;TNKS2;CDC37;HEY2;FDX1L;CTDP1;KPNA3
Diseases associated with glycosaminoglycan metabolismACAN;KERA;PRELP;OGN;FMOD
Diseases of glycosylationKERA;PRELP;FMOD;ACAN;OGN
Glycosaminoglycan metabolismB3GNT1;SLC26A1;CHP;B3GNT3;B3GAT2;HS3ST6;HPSE;LYVE1;OMD
Keratan sulfate biosynthesisB3GNT1;B3GNT2A;KERA;FMODA;SLC35D2;ST3GAL3A;OMD;B3GNT2;B3GNT3

OGN has several biochemical functions, for example, NOT Roundabout binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OGN itself. We selected most functions OGN had, and list some proteins which have the same functions with OGN. You can find most of the proteins on our site.

Function Related Protein
NOT Roundabout bindingFMODA;EPYC;FMOD;OGN
growth factor activityINHBAB;HDGFRP3;THBS4B;NUDT6;JAG2;TFF1;IL8L2;INHBAA;CECR1A
heparin bindingADAMTS3;CCL15;VEGFAB;FGFR1A;LXN;NOV;CXCL10;FSTL1;CHRD
protein bindingTLX3;SYNPO2L;PFDN4;HUS1;RPF1;CCDC12;HNRNPD;KNDC1;SRSF1

OGN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OGN here. Most of them are supplied by our site. Hope this information will be useful for your research of OGN.

ABL1; SRC; CRK

Research Area

Related articles

Heppner, JM; Zaucke, F; et al. Extracellular matrix disruption is an early event in the pathogenesis of skeletal disease in mucopolysaccharidosis I. MOLECULAR GENETICS AND METABOLISM 114:146-155(2015).
Chun, YS; Park, Y; et al. O-GlcNAcylation Promotes Non-Amyloidogenic Processing of Amyloid-beta Protein Precursor via Inhibition of Endocytosis from the Plasma Membrane. JOURNAL OF ALZHEIMERS DISEASE 44:261-275(2015).
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