OSBP
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Official Full Name
oxysterol binding protein -
Overview
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the;nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase. -
Synonyms
OSBP;oxysterol binding protein;oxysterol-binding protein 1;OSBP1;OSBP 1;OSBP1_HUMAN;Oxysterol binding protein 1
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| OSBP-3250R | Recombinant Rhesus monkey OSBP Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| OSBP-7336Z | Recombinant Zebrafish OSBP | Mammalian Cells | Zebrafish | His |
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| OSBP-8006H | Recombinant Human OSBP protein, His & T7-tagged | E.coli | Human | His&T7 | Thr546~Phe807 |
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| OSBP-3544HCL | Recombinant Human OSBP 293 Cell Lysate | HEK293 | Human | Non |
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| OSBP-1587H | Recombinant Human OSBP Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| OSBP-1587H-B | Recombinant Human OSBP Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| OSBP-3068R | Recombinant Rhesus Macaque OSBP Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| OSBP-3068R-B | Recombinant Rhesus Macaque OSBP Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| Osbp-4606M | Recombinant Mouse Osbp Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| OSBP-774HFL | Recombinant Full Length Human OSBP Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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Involved Pathway
OSBP involved in several pathways and played different roles in them. We selected most pathways OSBP participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid de novo biosynthesis | ACER1,VAPB,CERS3B,GDF1,FA2H,PPM1L,CERS5,COL4A3BP,SGMS2,CERS4A |
| Metabolism of lipids and lipoproteins | CYP27A1,GRHL1,CYP2R1,SLC27A5,CRAT,MED9,MED26,ACOT11B,SIN3B,MED6 |
| Metabolism | AKR1C6,YY2,CYP27A1,CERS3B,NEU3,PNPLA8,PNP5B,ATP5H,MARCKSA,NUDT3A |
| Sphingolipid metabolism | DEGS2,KDSR,SGMS2,ARSD,ARSI,NEU3.5,SMPD1,SMPD4,CERS4A,UGT8A |
Protein Function
OSBP has several biochemical functions, for example, oxysterol binding,phosphatidylinositol-4-phosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSBP itself. We selected most functions OSBP had, and list some proteins which have the same functions with OSBP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxysterol binding | OSBPL5,RORA,RORC,GPR183 |
| protein binding | KLK15,LRP4,PKM2,RAB17,CTC1,UBASH3A,ACTN2,MAPK4,HIST1H2AM,MED18 |
| sterol transporter activity | SCP2A,C20orf79,NPC1,SCP2 |
| protein domain specific binding | HIST1H4N,MECP2,TBL1X,LIN7B,HNRNPM,THRA,RAN,PPP3R1,ST13,IKBKG |
| phosphatidylinositol-4-phosphate binding | PLEKHA8,LANCL2,JPH2,ARFIP1,COL4A3BP,D6WSU116E,OSBPL8,GOLPH3L,MBL1,CLSTN2 |
Interacting Protein
OSBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSBP here. Most of them are supplied by our site. Hope this information will be useful for your research of OSBP.
sseL;sseL;FKBP6;CSNK2A1;SP1;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;VAPA
Resources
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References
- Udagawa, O; Ito, C; et al. Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. GENES TO CELLS 19:13-27(2014).
- Nhek, S; Ngo, M; et al. Regulation of Oxysterol-binding Protein Golgi Localization through Protein Kinase D-mediated Phosphorylation. MOLECULAR BIOLOGY OF THE CELL 21:2327-2337(2010).
