OSBP

  • Official Full Name

    oxysterol binding protein
  • Overview

    Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the;nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase.
  • Synonyms

    OSBP;oxysterol binding protein;oxysterol-binding protein 1;OSBP1;OSBP 1;OSBP1_HUMAN;Oxysterol binding protein 1

Recombinant Proteins

  • Rhesus macaque
  • Zebrafish
  • Human
  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • T7
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
OSBP-3250R Recombinant Rhesus monkey OSBP Protein, His-tagged Mammalian Cells Rhesus macaque His
OSBP-7336Z Recombinant Zebrafish OSBP Mammalian Cells Zebrafish His
OSBP-8006H Recombinant Human OSBP protein, His & T7-tagged E.coli Human His&T7 Thr546~Phe807
OSBP-3544HCL Recombinant Human OSBP 293 Cell Lysate HEK293 Human Non
OSBP-1587H Recombinant Human OSBP Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
OSBP-1587H-B Recombinant Human OSBP Protein Pre-coupled Magnetic Beads HEK293 Human
OSBP-3068R Recombinant Rhesus Macaque OSBP Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
OSBP-3068R-B Recombinant Rhesus Macaque OSBP Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Osbp-4606M Recombinant Mouse Osbp Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
OSBP-774HFL Recombinant Full Length Human OSBP Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.

    Involved Pathway

    OSBP involved in several pathways and played different roles in them. We selected most pathways OSBP participated on our site, such as Metabolism,Metabolism of lipids and lipoproteins,Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid metabolism SGPP1,LASS5,PPAP2B,SMPD3,B4GALT6,ARSI,ARSD,NEU3.4,SPTLC2A,ACER1
    Metabolism SLC26A1,APOBB.1,CYP17A1,FABP11B,FIG4,HSD17B11,ALOX5B.2,UCP2,CYP2S1,SLCO1B1
    Metabolism of lipids and lipoproteins CTGF,CHAT,CDK19,BCHE,ARF3,PMVK,APOA4B.1,CYP46A1,CYP4F11,PHOSPHO1
    Sphingolipid de novo biosynthesis CERS4A,ACER1,FA2H,PPM1L,PPM1LB,CERS3B,VAPB,COL4A3BP,SPTLC1,SGMS2

    Protein Function

    OSBP has several biochemical functions, for example, oxysterol binding,phosphatidylinositol-4-phosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSBP itself. We selected most functions OSBP had, and list some proteins which have the same functions with OSBP. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TNFAIP8L2,TAS2R16,ENDOG,BRD7,UBQLN1,FAM109B,WDTC1,CYSLTR2,E2F2,SLC26A6
    phosphatidylinositol-4-phosphate binding SH3PXD2B,PRRC2B,ARFIP1,PLEKHA8,JPH2,ARFIP2,LANCL2,GOLPH3L,CLSTN2,PLEKHF1
    oxysterol binding RORC,RORA,GPR183,OSBPL5
    sterol transporter activity C20orf79,SCP2A,SCP2,NPC1
    protein domain specific binding FOXA1,FOXA2,TUBB,NEDD4,CNOT1,NFASC,RHOA,SKI,GABRR2,SKIL

    Interacting Protein

    OSBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSBP here. Most of them are supplied by our site. Hope this information will be useful for your research of OSBP.

    sseL;sseL;FKBP6;CSNK2A1;SP1;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;VAPA

    Resources

    References

    • Udagawa, O; Ito, C; et al. Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family. GENES TO CELLS 19:13-27(2014).
    • Nhek, S; Ngo, M; et al. Regulation of Oxysterol-binding Protein Golgi Localization through Protein Kinase D-mediated Phosphorylation. MOLECULAR BIOLOGY OF THE CELL 21:2327-2337(2010).

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