P2RX6 Protein


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Official Full Name purinergic receptor P2X, ligand-gated ion channel, 6
Background The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.
Synonyms P2RX6; purinergic receptor P2X, ligand-gated ion channel, 6; P2RXL1, purinergic receptor P2X like 1, orphan receptor; P2X purinoceptor 6; MGC129625; P2X6; P2XM; ATP receptor; P2RXL1; Purinergic receptor; Purinergic receptor P2X like 1; Skeletal muscle expressed P2X; purinoceptor P2X6; purinoreceptor P2X6; skeletal muscle-expressed P2X; purinergic receptor P2X-like 1, orphan receptor
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human P2RX6-1493H Recombinant Human P2RX6, His-tagged E.coli His
    Rat P2RX6-4231R Recombinant Rat P2RX6 Protein Mammalian Cell His
    Human P2RX6-3496HCL Recombinant Human P2RX6 293 Cell Lysate HEK293 N/A
    Rat P2rx6-1890R Recombinant Rat P2rx6 Protein, His-tagged E.coli N-His
    Human P2RX6-2539H Recombinant Human P2RX6 Protein, His-tagged E.coli N-His

    P2RX6 involved in several pathways and played different roles in them. We selected most pathways P2RX6 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway DRD1B; PTGER3; GRM1; PLCD1A; CACNA1BA; ATP2A2A; MYLK; TBXA2R; PPP3R2; ATP2B1A
    Neuroactive ligand-receptor interaction NTSR2; HTR1E; NPY5R; P2RY8; GABRQ; GABBR2; OPRM1; CCKBR; PTGER2A; GNRHR

    P2RX6 has several biochemical functions, for example, ATP binding, channel activity, extracellular ATP-gated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX6 itself. We selected most functions P2RX6 had, and list some proteins which have the same functions with P2RX6. You can find most of the proteins on our site.

    Function Related Protein
    channel activity BAX; BCL2; BAXB; STEAP1; BAXA; PANX1B; MAL; GJA8; TRPA1; PANX1A
    extracellular ATP-gated cation channel activity P2RX5; P2RX2; P2RX4A; P2RX3A; P2RX3; P2RX3B; P2RX4; NNR; P2RX6; P2RX1
    identical protein binding RIPK1; ERN1; CBS; UBE4A; BRAP; SIAH1; CUBN; TYSND1; SCHIP1; DCTPP1
    purinergic nucleotide receptor activity P2RX4B; P2RX3A; P2RX3B; P2RX8; P2RX2; P2RX6; NNR; P2RX3; P2RX1; P2RX4A
    transmembrane signaling receptor activity MARCO; IL1R1; BAI2; SELE; LGR5; CLEC1B; FZD3B; CD79A; KIR2DL4; P2RX5

    P2RX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX6.


    Xue, CC; Xie, L; et al. Analgesic mechanism of electroacupuncture in a rat L5 spinal nerve ligation model. EXPERIMENTAL AND THERAPEUTIC MEDICINE 9:987-991(2015).
    Tackett, BC; Sun, HD; et al. P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 307:G1073-G1087(2014).

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