P2RX6
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Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 6 -
Overview
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. -
Synonyms
P2RX6;purinergic receptor P2X, ligand-gated ion channel, 6;P2RXL1, purinergic receptor P2X like 1, orphan receptor;P2X purinoceptor 6;MGC129625;P2X6;P2XM;ATP receptor;P2RXL1;Purinergic receptor;Purinergic receptor P2X like 1;Skeletal muscle expressed P2X;purinoceptor P2X6;purinoreceptor P2X6;skeletal muscle-expressed P2X;purinergic receptor P2X-like 1, orphan receptor
Recombinant Proteins
- Human
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| P2RX6-1493H | Recombinant Human P2RX6, His-tagged | E.coli | Human | His | 1-330aa | |
| P2RX6-4231R | Recombinant Rat P2RX6 Protein | Mammalian Cells | Rat | His |
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| P2RX6-3496HCL | Recombinant Human P2RX6 293 Cell Lysate | HEK293 | Human | Non |
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| P2rx6-1890R | Recombinant Rat P2rx6 Protein, His-tagged | E.coli | Rat | His | Leu86-Gly270 |
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| P2RX6-2539H | Recombinant Human P2RX6 Protein, His-tagged | E.coli | Human | His | Lys61-Gly333 |
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| P2RX6-3893R | Recombinant Rat P2RX6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| P2RX6-3893R-B | Recombinant Rat P2RX6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
P2RX6 involved in several pathways and played different roles in them. We selected most pathways P2RX6 participated on our site, such as Calcium signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | Gh,GALR3,GHRHRL,LPAR6,TACR1A,HTR1F,CHRNB3A,TAAR14H,HCRTR2,CHRM5B |
| Calcium signaling pathway | RYR3,ITPKB,PPIAA,GNA15,SPHK2,PLCB2,VDAC3,ERBB3A,CHRM5B,STIM1 |
Protein Function
P2RX6 has several biochemical functions, for example, ATP binding,channel activity,extracellular ATP-gated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX6 itself. We selected most functions P2RX6 had, and list some proteins which have the same functions with P2RX6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular ATP-gated cation channel activity | P2RX5,P2RX2,P2RX4B,NNR,P2RX3A,P2RX1,P2RX4,P2RX8,P2RX4A,P2RX3 |
| ATP binding | RTEL1,DQX1,RET,TYRO3,KIF17,ABCG4B,FLT4,UBE2D4,ARAF,RECQL |
| identical protein binding | LDHA,NEFL,PRMT8,GOT1,PCNA,PVRL2,THBS1,EID3,TP63,ACPP |
| channel activity | PANX1A,BAXA,MAL,BCL2,TRPA1,PANX1B,CHRNB1,BAX,BAXB,STEAP1 |
| transmembrane signaling receptor activity | SORL1,GPR98,DNER,KLRB1,P2RX5,GLP1R,CD79B,OR2A4,OR4C12,TNFRSF11A |
| purinergic nucleotide receptor activity | P2RX1,P2RX2,P2RX4B,P2RX8,P2RX4A,P2RX4,P2RX7,NNR,P2RX3B,P2RX3A |
Interacting Protein
P2RX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX6.
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References
- Xue, CC; Xie, L; et al. Analgesic mechanism of electroacupuncture in a rat L5 spinal nerve ligation model. EXPERIMENTAL AND THERAPEUTIC MEDICINE 9:987-991(2015).
- Tackett, BC; Sun, HD; et al. P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 307:G1073-G1087(2014).
