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P2RX6

Official Full Name

purinergic receptor P2X, ligand-gated ion channel, 6
Overview

The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified.
Synonyms

P2RX6; purinergic receptor P2X, ligand-gated ion channel, 6; P2RXL1, purinergic receptor P2X like 1, orphan receptor; P2X purinoceptor 6; MGC129625; P2X6; P2XM; ATP receptor; P2RXL1; Purinergic receptor; Purinergic receptor P2X like 1; Skeletal muscle expressed P2X; purinoceptor P2X6; purinoreceptor P2X6; skeletal muscle-expressed P2X; purinergic receptor P2X-like 1, orphan receptor;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	P2RX6-1493H	Recombinant Human P2RX6, His-tagged	E.coli	His	1-330aa	$319 / 25μg
Human	P2RX6-3496HCL	Recombinant Human P2RX6 293 Cell Lysate	HEK293	Non		Inquiry
Human	P2RX6-2539H	Recombinant Human P2RX6 Protein, His-tagged	E.coli	His	Lys61-Gly333	Inquiry
Rat	P2RX6-4231R	Recombinant Rat P2RX6 Protein	Mammalian Cell	His		Inquiry
Rat	P2rx6-1890R	Recombinant Rat P2rx6 Protein, His-tagged	E.coli	His	Leu86-Gly270	Inquiry
Rat	P2RX6-3893R	Recombinant Rat P2RX6 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	P2RX6-3893R-B	Recombinant Rat P2RX6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

P2RX6 involved in several pathways and played different roles in them. We selected most pathways P2RX6 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	PPP3CCA;ADRB2A;ORAI1B;SLC25A4;NOS2;PPIFA;ADORA2B;ITPR3;CALM2B
Neuroactive ligand-receptor interaction	ADRB2B;MTNR1BB;GRM6B;P2RX2;P2RY2;TAAR14D;CHRNB3A;DRD2L;CHRNA4B

P2RX6 has several biochemical functions, for example, ATP binding, channel activity, extracellular ATP-gated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX6 itself. We selected most functions P2RX6 had, and list some proteins which have the same functions with P2RX6. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	SRPK1B;SMARCAL1;STK11;MTOR;ADRBK2;RAD54L;MAP2K1;RAD51D;STK32B
channel activity	PANX2;APNL;BCL2;PANX1A;MAL;P2RX6;GJA8;CHRNB1;TRPA1
extracellular ATP-gated cation channel activity	P2RX8;P2RX3B;P2RX6;P2RX2;P2RX4B;P2RX1;P2RX3A;P2RX4;NNR
identical protein binding	SNCAIP;PDGFB;HTT;SYT9;ORAI1;TNK2;MSTN;HJURP;DPY30
purinergic nucleotide receptor activity	P2RX5;P2RX3A;P2RX4A;P2RX3;P2RX6;P2RX4;NNR;P2RX7;P2RX2
transmembrane signaling receptor activity	PTH1RB;OR12D2;GHRHR2;CLDN3;GPR126;OR103-4;KLRC2;MARCO;LILRB3

P2RX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX6.

SRPK1

Research Area

Ion Channels and Regulators

Xue, CC; Xie, L; et al. Analgesic mechanism of electroacupuncture in a rat L5 spinal nerve ligation model. EXPERIMENTAL AND THERAPEUTIC MEDICINE 9:987-991(2015).

Tackett, BC; Sun, HD; et al. P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 307:G1073-G1087(2014).