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EP300

  • Official Full Name

    E1A binding protein p300

  • Overview

    This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
  • Synonyms

    EP300; E1A binding protein p300; histone acetyltransferase p300; KAT3B; p300; p300 HAT; E1A-binding protein, 300kD; E1A-associated protein p300; RSTS2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • C
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human EP300-42H Active Recombinant Human EP300 protein E.coli N/A
Human EP300-1074H Active Recombinant Human E1A Binding Protein P300, 302-531aa E.coli N/A
Human EP300-442H Active Recombinant Human EP300, His-tagged Sf21 Insect Cell His
Human EP300-28677TH Recombinant Human EP300 protein, Flag-tagged Insect Cell Flag
Human EP300-3346H Recombinant Human EP300 Protein, GST-tagged Wheat Germ GST
Human EP300-28680TH Recombinant Human EP300, FLAG-tagged Flag
Human EP300-1584H Recombinant Human E1A Binding Protein P300, GST-tagged Sf9 Insect Cell GST
Human EP300-80H Recombinant Human EP300 protein, His-tagged E.coli His 1040-1161
Human EP300-43H Recombinant Human EP300 Protein, GST-tagged E. coli GST
Human EP300-202H Recombinant Human EP300 protein, DDK-tagged Insect Cell DDK Tyr1066-Lys1707
Human EP300-1585H Recombinant Human E1A Binding Protein P300, GST-tagged Sf9 Insect Cell GST
Human EP300-28678TH Recombinant Human EP300 N/A
Human EP300-610H Recombinant Human EP300 Mammalian Cell His
Human EP300-2862H-B Recombinant Human EP300 Protein Pre-coupled Magnetic Beads HEK293
Human EP300-04H Recombinant Human EP300 Protein (catalytic domain, 965-1810), N-Flag-tagged Insect Cell N-Flag 965-1810
Human EP300-414H Recombinant Human EP300 Protein, His-tagged E.coli His Glu1351~Ile1601
Human EP300-02H Recombinant Human EP300 Protein, N-Flag-tagged Insect Cell N-Flag
Human EP300-2964H Recombinant Human EP300 Protein (His2283-His2414), N-His tagged E.coli N-His His2283-His2414
Human EP300-2862H Recombinant Human EP300 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human EP300-85H Recombinant Human EP300 Protein, His-tagged E.coli His
Human EP300-2965H Recombinant Human EP300 Protein E.coli Tag Free
Human EP300-03H Recombinant Human EP300 Protein (Full Length), N-Flag-tagged Insect Cell N-Flag
Human EP300-12H Recombinant Human EP300 Protein (bromodomain, 1041-1161), N-His and C-Flag-tagged E.coli N-His and C-Flag 1041-1161
Mouse Ep300-415M Recombinant Mouse Ep300 Protein, His-tagged E.coli His Gly2124~Ser2397
Mouse Ep300-49M Recombinant Mouse Ep300 Protein, GST-tagged E.coli GST 165
Rat Ep300-416R Recombinant Rat Ep300 protein, His-GST-tagged E.coli His/GST Met1~Pro158
Monkey EP300-1481R Recombinant Monkey Ep300 Protein, His tagged HEK293 N-His
Dog EP300-01D Recombinant Dog Ep300 Protein, His tagged HEK293 N-His
Rhesus Macaque EP300-1306R-B Recombinant Rhesus Macaque EP300 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque EP300-1306R Recombinant Rhesus Macaque EP300 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • EP300 Related Articles
  • EP300 Related Research Area

EP300 involved in several pathways and played different roles in them. We selected most pathways EP300 participated on our site, such as cAMP signaling pathway, HIF- signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with EP300 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cAMP signaling pathwayMAPK3;AMH;PDE4C;GNAI3;AKT1;ATP2B4;PIK3R5;BAD;RHOA
HIF- signaling pathwayLTBR;TFRC;PDHA1;INSR;EIF4E1B;MTOR;Trf;PGK1;INS2
FoxO signaling pathwayAGAP2;FOXO4;IGF1RB;AKT2;BNIP3;CDKN1BB;GADD45AB;BCL6A;IKBKB
Cell cycleMAD1L1;PTTG1;YWHAG;NSL1;MIS18A;CDC26;TUBGCP5;ORC1L;CDC23
Wnt signaling pathwayMAPK8A;FZD2;WNT5A;ROCK2;PPP3R1;WNT7B;SKP1;RAC1;RAC3
Notch signaling pathwayTLE3A;CIR1;TUBB3;DLA;PSEN2;DLL4;MARK2;MFNG;DLL1
TGF-beta signaling pathwayBMP2B;SMAD7B;PPP2R1A;BMP7;BMPR2;BMP7B;NBL1;ID1;MAPK1
Adherens junctionPTPRM;ERBB2;TCF7;RAC1A;CDC42;PVRL1B;CTNNB1;SRC;RAC3A
Jak-STAT signaling pathwayIL6R;STAT6;IL9R;IL5;GM13305;CSH1;IL7;GM-CSF;TSLP
Long-term potentiationCAMK2D;ITPR1;RPS6KA6;MAP2K2;RAP1B;MAP2K1;PPP3R2;MAPK3;CALM3
MelanogenesisCREB3L3L;GNAI2;GNA15.4;EDNRBA;WNT8B;CAMK2D2;KITLGB;MITFB;WNT16
Thyroid hormone signaling pathwayRHEB;THRB;AKT1;PLCD4;MED13L;CASP9;PFKFB2;SLC16A2;PIK3R2
Huntingtons diseaseCOX4I1;ATP5D;PPIF;COX6B2;COX7B2;NDUFS3;PPARG;NDUFB1;POLR2J2
TuberculosisEEA1;IL18;RIPK2;IFNA1;HLA-DMB;ATP6V0D2;FCER1G;BAX;BID
Hepatitis BPIK3CB;MYD88;IL6;Fasl;MAP3K1;PIK3R1;IFNA6;GRB2;Ifna11
Influenza AIFIH1;HSPA6;IRF3;PIK3R5;MAPK13;IFNB1;TLR4;PIK3CG;NFKBIA
HTLV-I infectionAdcy4;TP53INP1;TNFRSF13C;WNT4;CANX;NFATC4;IL2RA;NFKB1;ITGB2L
Herpes simplex infectionTNFRSF1A;SRSF2;TAF3;HLA-DRB5;EP300;Ifna15;TNFB;LTA;TAF4B
Epstein-Barr virus infectionTP53;SNW1;TRAF3;YWHAG;POLR2J3;POLR3C;MAPK9;NFKBIE;CCNA2
Pathways in cancerPRKACG;MMP9;GNGT1;DAPK1;NKX3;PIK3CB;CCNE1;PGF;STK4
Viral carcinogenesisRB1;GTF2A2;CCND1;HIST1H2BQ;DDX3X;HIST1H2BF;NFKB2;TRAF2;REL
MicroRNAs in cancerNOTCH4;PRKCG;PRKCB;ERBB2;STMN1;TRP63;BMPR2;VIM;TP63
Renal cell carcinomaPTPN11;NRAS;EGLN1;PIK3CA;PAK2;GAB1;MAPK1;HIF1A;PAK1
Prostate cancerPIK3CG;FOXO1;BCL2;SOS1;FGFR2;PIK3CA;SMARCC2;ARID1A;NRAS

EP300 has several biochemical functions, for example, DNA binding, NF-kappaB binding, RNA polymerase II activating transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EP300 itself. We selected most functions EP300 had, and list some proteins which have the same functions with EP300. You can find most of the proteins on our site.

Function Related Protein
DNA bindingMCM2;MEIS4.1A;OASL;HOMEZ;POLDIP2;JRK;TAF1D;MAFBA;LCOR
NF-kappaB bindingBCL10;NPM1;MTDH;FOXP3;TAF4B;HDAC3;ANXA4;SNAI1A;ANKRD42
RNA polymerase II activating transcription factor bindingZFPM1;TBX6;RB1;NHLH2;DUSP26;TBX20;EP300;NFE2L2;IFI27
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFUBP3;SP1;ALS2CR8;CREB3;SIX5;SMAD4;ESRRA;ZNF331;PHOX2B
RNA polymerase II core promoter sequence-specific DNA bindingPAX8;H3F3A;GATA6;NFIL3;WBP2;H2AFY;NR4A2;GATA3;RREB1
SMAD bindingEP300;SOD3;COL5A2;TCF12;FLNA;SKOR1;ACVR1B;MEF2A;SKI
acetyltransferase activityMBOAT1;LPCAT3;NAT14;CML2;Nat3;AANAT2;KAT2B;EP300;HHAT
activating transcription factor bindingHDAC7;RELA;DGKQ;ATOH8;MEF2D;MEF2C;PPARG;HDAC4;PSIP1
androgen receptor bindingRAN;NRIP1;DDX5;KDM1A;KDM4C;GRIP1;WIPI1;CALR;CCNE1
bHLH transcription factor bindingTCF3A;SOX9;RUNX2;PSMD9;TCF3;ISL1;BHLHE40;SP1;IKZF4
beta-catenin bindingMED12;CDH24;BCL9;SOX9;TCF7L2;TAX1BP3;LEF1;CD2AP;NF2
chromatin DNA bindingHIST1H1A;GRHL2;GRHL1;MYOD1;VAX2;EP300;RUVBL2;PRDM14;SLAMF7
chromatin bindingCITED2;CRTC2;JUN;L3MBTL1;GATA5;MNT;SMARCD1;STAG2;HESX1
core promoter bindingKLF4;RB1;RELB;KDM3A;E2F2;INSM1B;AGO1;MYBBP1A;SFPI1
damaged DNA bindingCRY-DASH;CRY2;TRPC2;POLI;NEIL3;POLD1;RAD52;PNKP;APTX
glucocorticoid receptor bindingEP300;YWHAH;GRIP1;NR4A2;STAT3;STAT5B;NRIP1;FKBP4;CEBPB
histone acetyltransferase activityKAT7;TAF1L;ATF2;CREBBP;CLOCK;EP300;KAT7A;KAT6A;CDYL
lysine N-acetyltransferase activity, acting on acetyl phosphate as donorNAT8;RHBDL1;KAT2B;ESCO2;EP300;CEACAM21;NAT8B
mitogen-activated protein kinase bindingATF7;CDK5RAP3;MAPKAPK2B;SIRT1;TNIP1;GTF2I;TPR;MAPK7;PTPRJ
nuclear hormone receptor bindingCRX;NRIP1;EP300;CRY1;HIF1A;NCOA2;NCOA3;TACC2;TCF7L2
p53 bindingANKRD1;RCHY1;MDM2;TRIM24;TP73;PTTG1IP;GSK3B;BCL2L12;HTT
peroxisome proliferator activated receptor bindingEP300;NR0B2;NFATC4;ASXL2;HMGA1;ASXL1;PRMT2;MED1;HMGA1-RS1
pre-mRNA intronic bindingRBM4;RNPC3;EP300;SOX9;PRPF8;HNRNPA2B1;RBM41
protein C-terminus bindingSP1;ARL6IP5;LCK;BAIAP2;DDX1;SREBF2;VPS4A;CORO1A;KSR1
protein antigen bindingEP300;ITGA4;KLRC2;KLRD1;H2-AB1
protein bindingITGA3;YWHAZ;PIKFYVE;FAM53C;ALKBH6;HIST1H3A;AP1G1;MYBBP1A;DPM1
protein complex bindingMTHFR;CRHR1;KAT2B;TXN2;STK11;NFKBIA;TMED10;BAX;KRT8
transcription coactivator activityMED27;MAML1;CCNE1;MAML2;HAND1;TADA2A;MED26;ABRA;CCAR1
contributes_to transcription coactivator activityEP300;PHF2;CREBBP;ARID5B
transcription factor bindingNLRP3;RNF222;PARK7;GTF2B;SORBS3;STK36;ARNT;TCF7L2;AIP
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingMAF;ZGLP1;BARHL1B;EP300;ATF5;FOXO3;PKNOX1;RAD21;SRF
transferase activity, transferring acyl groupsACAA1A;GGT7;NAT15;CDYL;Nat3;LYCAT;MBOAT7;ZDHHC24;GGACT.1
zinc ion bindingAPOBEC3F;UBR2;ASTL;RNF139;SIAH2L;RTN4IP1;NR4A2B;ANPEPA;ZMIZ1A

EP300 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EP300 here. Most of them are supplied by our site. Hope this information will be useful for your research of EP300.

HIF1A; TP53

Vieweg, M; Dvorakova-Hortova, K; et al. Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients. CLINICAL EPIGENETICS 7:-(2015).
Cho, YA; Hong, JS; et al. The role of p300 in the tumor progression of oral squamous cell carcinoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE 44:185-192(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does EP300 impact developmental abnormalities? 11/12/2022

EP300 is crucial for embryonic development, and mutations in the EP300 gene can lead to developmental abnormalities. Understanding its role is essential for potential interventions.

How does EP300 contribute to neurodegenerative disorders? 09/22/2021

EP300 is involved in neuronal function and survival. Dysregulation of EP300 has been observed in neurodegenerative diseases like Alzheimer's and Parkinson's.

Are there experimental treatments targeting EP300 in neurodegenerative disorders? 06/20/2021

Research is underway to explore drugs that modulate EP300 activity for potential therapeutic interventions in neurodegenerative disorders, but clinical applications are still in the early stages.

Are there any ongoing clinical trials targeting EP300 in cancer treatment? 07/07/2017

Yes, there are clinical trials exploring the therapeutic potential of targeting EP300 in various cancer types, focusing on its role in controlling cell proliferation and survival.

Are there drugs targeting EP300 in cardiovascular diseases? 03/26/2016

While there are no specific drugs targeting EP300 approved for cardiovascular diseases, ongoing research aims to identify compounds that can modulate its activity for therapeutic purposes.

Customer Reviews (3)

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Reviews
09/22/2022

    It has consistently demonstrated outstanding results, consistently producing clear and sharp bands, allowing for accurate and reliable protein detection and quantification.

    03/09/2021

      Its stability and purity make it an ideal candidate for studying protein structures at a high resolution, providing crucial insights into the organization and function of the EP300 protein.

      07/07/2016

        I highly recommend the EP300 protein for its exceptional performance in Western blot analysis.

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