P4HA1

  • Official Full Name

    prolyl 4-hydroxylase, alpha polypeptide I

  • Overview

    This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms

    P4HA1; prolyl 4-hydroxylase, alpha polypeptide I; P4HA, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide I; prolyl 4-hydroxylase subunit alpha-1; C P4Halpha(I); collagen prolyl 4 hydroxylase alpha(I); 2-oxoglutarate-4-dioxygenase subunit alpha-1; 4-hydroxylase, alpha I subunit; 4-PH alpha-1; P4HA; P4HA1_HUMAN; Procollagen-proline; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; C-P4Halpha(I); collagen prolyl 4-hydroxylase alpha(I); procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human P4HA1-3055TH Recombinant Human P4HA1, MYC/DDK-tagged HEK293 Myc/DDK
Human P4HA1-30543TH Recombinant Human P4HA1 Wheat Germ N/A 534 amino acids
Human P4HA1-3482HCL Recombinant Human P4HA1 293 Cell Lysate HEK293 N/A
Human P4HA1-3483HCL Recombinant Human P4HA1 293 Cell Lysate HEK293 N/A
Human P4HA1-3009H Recombinant Human P4HA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human P4HA1-2637H Recombinant Human P4HA1 Protein (18-534 aa), His-tagged E.coli His 18-534 aa
Human P4HA1-355HF Recombinant Full Length Human P4HA1 Protein In Vitro Cell Free System 534 amino acids
Human P4HA1-6110H Recombinant Human P4HA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human P4HA1-2591HFL Recombinant Full Length Human P4HA1, Flag-tagged Mamanlian cells Flag
Mouse P4ha1-4640M Recombinant Mouse P4ha1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat P4ha1-1177R Recombinant Rat P4ha1 protein, His & T7-tagged E.coli His/T7 Val205~Glu534 (Accession # P54001)
Rat P4HA1-4240R Recombinant Rat P4HA1 Protein Mammalian Cell His
Rat P4HA1-3902R Recombinant Rat P4HA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat P4HA1-3902R-B Recombinant Rat P4HA1 Protein Pre-coupled Magnetic Beads HEK293
Chicken P4HA1-4216C Recombinant Chicken P4HA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • P4HA1 Related Research Area

P4HA1 involved in several pathways and played different roles in them. We selected most pathways P4HA1 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arginine and proline metabolismPYCR1A;DAO.2;SAT1A.2;GOT2;GOT2A;MAOA;AZIN2;ALDH2.2;ARG1
Metabolic pathwaysPCCB;SDHDA;GALNTL6;NDUFS7;PIK3C2G;PGP;DDOST;ADSSL;NDUFA9A

P4HA1 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA1 itself. We selected most functions P4HA1 had, and list some proteins which have the same functions with P4HA1. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingOGFOD2;OGFOD3;PLOD1A;P4HA1;EGLN1B;LEPRE1;PLOD2;TMLHE;P4HTM
iron ion bindingPHF2;CYP20A1;CYP4V2;TPH1A;FTL;PPEF1;CYP2X10.2;CYP2K22;CYP2P7
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenP4HA1;ALOX5B.2;ALOX5A;ALOX12E;ALOX8;P4HA2;P4HA1B;ALOX5B.3;ADOA
procollagen-proline 4-dioxygenase activityP4HA2;P4HA1;P4HA3;P4HA1B;P4HA1A
protein bindingWBP11;GAP43;SCRN1;TAF9;LOX;AGR3;CCDC67;ZFP57;SPI1B

P4HA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA1.

HTT; MLF2; IRS4; Wiz; MYC; cona_canen; Cdk1; Naa50; FIP1L1; AATK; ZNF526; IRF7; HDAC10; UBA5; RNF41; SLAIN2

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