P4HA1
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Official Full Name
prolyl 4-hydroxylase, alpha polypeptide I -
Overview
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
P4HA1;prolyl 4-hydroxylase, alpha polypeptide I;P4HA, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide I;prolyl 4-hydroxylase subunit alpha-1;C P4Halpha(I);collagen prolyl 4 hydroxylase alpha(I);2-oxoglutarate-4-dioxygenase subunit alpha-1;4-hydroxylase, alpha I subunit;4-PH alpha-1;P4HA;P4HA1_HUMAN;Procollagen-proline;Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I;C-P4Halpha(I);collagen prolyl 4-hydroxylase alpha(I);procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
Recombinant Proteins
- Rat
- Human
- Chicken
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- In Vitro Cell Free System
- His
- T7
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
Involved Pathway
P4HA1 involved in several pathways and played different roles in them. We selected most pathways P4HA1 participated on our site, such as Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine and proline metabolism | AMD1,CKMT1,DAO.1,ABP1,ARG2,AZIN2,GOT2B,PYCR2,LAP3,CKM |
| Metabolic pathways | ENPP1,CYP2A4,POLR1B,UGT5G1,RABGNT1,UQCR11,OGDHL,PIGQ,DHRS13L1,ACSM1 |
Protein Function
P4HA1 has several biochemical functions, for example, L-ascorbic acid binding,iron ion binding,oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA1 itself. We selected most functions P4HA1 had, and list some proteins which have the same functions with P4HA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | PTGIS,TMLHE,CYP51,CYP7B1,ALOX12E,FTL,CYP2V1,LEPREL2,AOX4,CYP2AA7 |
| procollagen-proline 4-dioxygenase activity | P4HA1B,P4HA2,P4HA3,P4HA1A |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | ALOX8,ALOX12E,P4HA1B,ALOX12B,P4HA3,BCO2,P4HA1A,TMLHE,ADOB,P4HA2 |
| protein binding | GAL,DPM3,SLC40A1,TRPC4AP,NME5,UBC,ITSN1,RARRES2,RBM22,ZNF143 |
| L-ascorbic acid binding | PLOD1A,LEPREL1,P4HA3,TMLHE,P4HA1B,P4HTM,PAM,OGFOD2,EGLN1,PLOD2 |
Interacting Protein
P4HA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA1.
HTT;MLF2;IRS4;Wiz;MYC;cona_canen;Cdk1;Naa50;FIP1L1;AATK;ZNF526;IRF7;HDAC10;UBA5;RNF41;SLAIN2
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