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PABPN1

  • Official Full Name

    poly(A) binding protein, nuclear 1

  • Overview

    This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3 ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5 end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
  • Synonyms

    PABPN1; poly(A) binding protein, nuclear 1; OPMD, PABP2, poly(A) binding protein, nuclear 1; polyadenylate-binding protein 2; PAB2; Nuclear poly(A) binding protein 1; PABII; PABP2; Poly(A) binding protein 2; Polyadenylate binding nuclear protein 1; Polyadenylate binding protein 2; ROX2; OTTHUMP00000164595; OTTHUMP00000164596; OTTHUMP00000246235; OTTHUMP00000246236; poly(A) binding protein II; OPMD; PABP-2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PABPN1-5004H Recombinant Human PABPN1, His-tagged E.coli His
Human PABPN1-403H Recombinant Human poly(A) binding protein, nuclear 1, His-tagged E.coli His
Human PABPN1-586H Recombinant Human PABPN1 Mammalian Cell His
Human PABPN1-01H Recombinant Human PABPN1 Protein, His-Tagged HEK293 His
Human PABPN1-3779H Recombinant Human PABPN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PABPN1-3779H-B Recombinant Human PABPN1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PABPN1-12293M Recombinant Mouse PABPN1 Protein Mammalian Cell His
Mouse PABPN1-6463M Recombinant Mouse PABPN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PABPN1-6463M-B Recombinant Mouse PABPN1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PABPN1-5999Z Recombinant Zebrafish PABPN1 Mammalian Cell His
Zebrafish PABPN1-12456Z Recombinant Zebrafish PABPN1 Mammalian Cell His
CBCRY37 Polyadenylate-binding Protein 2 E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PABPN1 Related Articles
  • PABPN1 Related Gene Family

PABPN1 involved in several pathways and played different roles in them. We selected most pathways PABPN1 participated on our site, such as mRNA surveillance pathway, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with PABPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayNXT2;PPP2R2A;PAPOLB;PPP2R2C;RNGTT;PABPN1L;PPP2R2BB;SMG1;NCBP2
Influenza ADNAJC3;OAS3;LOC780933;HLA-DMB;Ifna11;NUP98;TMPRSS13;HLA-DRB5;IFNA8

PABPN1 has several biochemical functions, for example, RNA binding, nucleic acid binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PABPN1 itself. We selected most functions PABPN1 had, and list some proteins which have the same functions with PABPN1. You can find most of the proteins on our site.

Function Related Protein
RNA bindingRAE1;RBMS1;TTC6;DKC1;CELF5;SMARCE1;WDHD1;RNASEL2;RBM8A
nucleic acid bindingZFP57;DDX51;MSI2A;EIF4A1B;RNASE9;PRDM8B;RNASEL3;SCRT1;ZFP287
nucleotide bindingRBM3;RBMY1A1;TYMS;DHX36;FYNB;TLK1A;CDC6;UBE2L3B;RBM12B1
poly(A) RNA bindingRP9;NONO;LLPH;HIST1H4K;GANAB;SNRPD1;CDKN2A;MRPS26;NOLC1
poly(A) bindingRBPMS;DDX3X;HNRPDL;ZC3H14;PABPC3;PABPC4;PAIP2B;PABPN1;EIF4A3
protein self-associationAGTR1B;ZSWIM2;ADAM8;ZNF496;NKX3-1;ACVR2A;EPB49;CTSB;CCL5

PABPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PABPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PABPN1.

Mylk; Ywhae

Impagliazzo, A; Tepper, AW; et al. Structural basis for a PABPN1 aggregation-preventing antibody fragment in OPMD. FEBS LETTERS 584:1558-1564(2010).
Hahn, S; Nesslinger, NJ; et al. Castration induces autoantibody and T cell responses that correlate with inferior outcomes in an androgen-dependent murine tumor model. INTERNATIONAL JOURNAL OF CANCER 125:2871-2878(2009).
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Reviews
09/13/2019

    Their team of experts is not only knowledgeable about the PABPN1 protein but is also dedicated to assisting researchers like myself in overcoming any challenges that may arise.

    01/27/2019

      This high-quality protein is crucial for the success of my experiments, ensuring that I obtain reliable and meaningful scientific findings.

      12/14/2016

        Whether it's modifying protocols, providing custom formulations, or offering personalized recommendations, their flexibility ensures that I have the necessary tools to carry out my experiments seamlessly.

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