padi4
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  • Official Full Name
  • peptidyl arginine deiminase, type IV
  • Background
  • This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
  • Synonyms
  • PADI4; peptidyl arginine deiminase, type IV; PADI5, peptidyl arginine deiminase, type V; protein-arginine deiminase type-4; PAD; PDI4; PDI5; EC 3.5.3.15; HL 60 PAD; PAD 4; PADI 4; PADI 5; PADI H protein; PADI5; PDI 4; PDI 5; Peptidyl arginine deiminase type IV; Peptidyl arginine deiminase type V; Peptidylarginine deiminase IV; Protein arginine deiminase; Protein arginine deiminase type 4; Protein arginine deiminase type IV; HL-60 PAD; PADI-H protein; OTTHUMP00000002482; protein-arginine deiminase type IV; peptidyl arginine deiminase, type V; PAD4
Cat.#:PADI4-203HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PADI4 Protein, MYC/DDK-tagged
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Cat.#:PADI4-313HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PADI4 Protein, His-tagged
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Cat.#:PADI4-1608Tag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PADI4 protein, GST-tagged
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Cat.#:PADI4-1608HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PADI4, GST-tagged
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Cat.#:PADI4-20HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PADI4, Flag-tagged
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Cat.#:PADI4-293HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PADI4 Protein, His-tagged
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Cat.#:PADI4-317HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PADI4, His-tagged
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Cat.#:PADI4-380HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PADI4, His-tagged
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Cat.#:PADI4-3871HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PADI4, His & GST tagged
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Cat.#:PADI4-12304MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PADI4 Protein
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Cat.#:PADI4-4251RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PADI4 Protein
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Cat.#:PADI4-630HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PADI4 cell lysate
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Involved Pathway

PADI4 involved in several pathways and played different roles in them. We selected most pathways PADI4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, protein citrullination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PADI4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
MORF4L2; GATAD2B; KDM5BB; ASH2L; KANSL3; ELP2; MSL2; KDM5D; ELP3; KDM5C
Chromatin organization
ELP3; SMARCA4; DNMT3A; RBBP5; KAT6A; BRD1; CCDC101; MSL2B; PRMT6; ATXN7
protein citrullination
PADI2; PADI3; PADI6; PADI4; PADI1

Protein Function

PADI4 has several biochemical functions, for example, arginine deiminase activity, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PADI4 itself. We selected most functions PADI4 had, and list some proteins which have the same functions with PADI4. You can find most of the proteins on our site.
Function
Related Protein
Function arginine deiminase activity
Related Protein PADI4
Function calcium ion binding
Related Protein SRR; CALML5; EGFL8; MYL12.1; CDH15; TNNC1B; TESCB; VCANB; PCDHA2; CCDC102A
Function protein binding
Related Protein C21orf7; ADAM12; DVL2; RFX4; AGAP2; PSMD2; MCC; FAM32A; A1CF; MED16
Function protein-arginine deiminase activity
Related Protein PADI3; PADI2; PADI1; PADI4; PADI6

Interacting Protein

PADI4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PADI4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PADI4.
ANXA4; LRRK2; DNPEP

PADI4 Related Articles

Guzman-Guzman, IP; Reyes-Castillo, Z; et al. Polymorphisms and functional haplotype in PADI4: Further evidence for contribution on rheumatoid arthritis susceptibility and anti-cyclic citrullinated peptide antibodies in a western Mexican population. IMMUNOLOGY LETTERS 163:214-220(2015).
Kochi, Y; Suzuki, A; et al. Genetic basis of rheumatoid arthritis: A current review. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 452:254-262(2014).