PAK7
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Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 7 -
Overview
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described -
Synonyms
PAK7;p21 protein (Cdc42/Rac)-activated kinase 7;PAK5;KIAA1264;MGC26232;OTTHUMP00000030260;p21(CDKN1A)-activated kinase 7;p21-activated kinase 7;p21CDKN1A-activated kinase 7;protein kinase PAK5;serine/threonine-protein kinase PAK7;EC 2.7.11.1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- Non
- His
- Avi
- Fc
Involved Pathway
PAK7 involved in several pathways and played different roles in them. We selected most pathways PAK7 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | RAC1,PIK3R2,CUL2,PIK3CA,PAK3,PIK3CG,BRAF,CDC42,EGLN2,RBX1 |
| Focal adhesion | VAV3B,RAP1B,LAMB2,RAC2,FLNA,CAV3,PTK2AB,VTNB,MYLK3,MYLK4 |
| ErbB signaling pathway | AKT2L,SHC3,CBLB,MAPK1,HRASA,ERBB3A,ARAF,CAMK2D2,RAF1B,TGFA |
| T cell receptor signaling pathway | PAK1,CABIN1,PPP3CB,PPP3R2,NFKBIB,PTPRC,MAPK11,NFATC1,MAP2K1,PIK3R3 |
| Regulation of Actin Cytoskeleton | FGF16,ACTN2,RAF1B,PFN2,ACTN1,PIK3R2,ARHGEF7,RHOAC,GNG12,CDC42 |
| Axon guidance | FGFR1B,EPHB4,CHL1,PPP3CA,KRAS,NRTN,RAC2,AP2A2,LIMK1,EFNA1A |
| Ras signaling pathway | GNG11,LAT,PRKACG,PIK3CA,RASGRF2,MRAS,FGFR3,TEK,RAP1A,MLLT4 |
Protein Function
PAK7 has several biochemical functions, for example, ATP binding,Rac GTPase binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK7 itself. We selected most functions PAK7 had, and list some proteins which have the same functions with PAK7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | TESK1,ACVR1L,CAMK2B1,DCAMKL2,BRAF,PRKCI,DCLK3,NEK3,RPS6KB2,PIK3R4 |
| Rac GTPase binding | RCC2,PKN1,OCRL,CDKL5,PAK2,HACE1,NCF2,SRGAP2A,NOX1,NOXA1 |
| ATP binding | IRAK3,MYO1D,NTRK3A,MAT2AL,NEK1,SCN8A,CAMKK2,CARNS1,ACTR3,ABCC2 |
Interacting Protein
PAK7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK7.
PKM;4757996;S100A9;S100A7;RPA3;CCDC59;HIGD1A;CDC42;ARRB2
PAK7 Related Signal Pathway
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