PCSK4
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Official Full Name
proprotein convertase subtilisin/kexin type 4 -
Overview
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014] -
Synonyms
PCSK4;proprotein convertase subtilisin/kexin type 4;PC4;SPC5
Recombinant Proteins
- Mouse
- Rat
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- E.coli
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PCSK4-12516M | Recombinant Mouse PCSK4 Protein | Mammalian Cells | Mouse | His |
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| PCSK4-4308R | Recombinant Rat PCSK4 Protein | Mammalian Cells | Rat | His |
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| PCSK4-85H | Recombinant Human PCSK4, GST-tagged | Wheat Germ | Human | GST |
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| PCSK4-1317HCL | Recombinant Human PCSK4 cell lysate | Human | Non |
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| PCSK4-3968R | Recombinant Rat PCSK4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| PCSK4-3968R-B | Recombinant Rat PCSK4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PCSK4-6564M | Recombinant Mouse PCSK4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PCSK4-6564M-B | Recombinant Mouse PCSK4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL31644HF | Recombinant Full Length Human Proprotein Convertase Subtilisin/Kexin Type 4(Pcsk4) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (114-755) |
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Involved Pathway
PCSK4 involved in several pathways and played different roles in them. We selected most pathways PCSK4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
PCSK4 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK4 itself. We selected most functions PCSK4 had, and list some proteins which have the same functions with PCSK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase activity | KLK1B16,PRSS12,PRSS2,PARL,PRSS45,GZMH,KLK4,PRSS39,TYSND1,TMPRSS13A |
Interacting Protein
PCSK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK4.
Resources
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References
- Raal, FJ; Honarpour, N; et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. LANCET 385:341-350(2015).
- Moriarty, PM; Jacobson, TA; et al. Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: Design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial. JOURNAL OF CLINICAL LIPIDOLOGY 8:554-561(2014).
