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Official Full Name PDE2A phosphodiesterase 2A, cGMP-stimulated
Background Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE2 enzyme belongs to a family of PDEs able to hydrolyse both intracellular second messengers, cAMP and cGMP
Synonyms PDE2A; phosphodiesterase 2A, cGMP-stimulated; cGMP-dependent 3,5-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase; PDE2A1; PED2A4; cGSPDE; CGS-PDE
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE4B-146H Recombinant Human PDE2A Protein, His-tagged Insect cell His
    Human PDE2A -906H Recombinant Human PDE2A , His tagged Insect Cell His
    Human PDE2A-07H Recombinant Human PDE2A Protein, His-tagged Insect Cell His
    Human PDE2A-29979TH Recombinant Human PDE2A Wheat Germ N/A
    Human PDE2A-472H Recombinant Human PDE2A, GST-tagged, Active Sf9 Insect Cell GST
    Human PDE2A-591HCL Recombinant Human PDE2A cell lysate Insect Cell N/A
    Human PDE2A-606H Recombinant Human PDE2A Mammalian Cell His
    Rhesus Macaque PDE2A-3347R Recombinant Rhesus monkey PDE2A Protein, His-tagged Mammalian Cell His
    Kit-1832 PDE2A Assay Kit I N/A
    Kit-1833 PDE2A Assay Kit II N/A

    PDE2A involved in several pathways and played different roles in them. We selected most pathways PDE2A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Olfactory transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism POLR2G; ENTPD5; GMPR; AMPD1; POLR2B; POLR3D; PRIM1; POLR1D; PRPS1L1; GUK1
    cGMP-PKG signaling pathway NFATC1; GUCY1B3; AKT1; NOS3; NPR1; PDE3B; BDKRB2; MYLK3; PIK3CG; ATP1B2
    Olfactory transduction OLFR186; ARRB1; GNG7; OR10A4; OR10H1; OR7C1; OLFR151; OR2L2; OR12D3; OLFR147
    Aldosterone synthesis and secretion CYP11A1; AGTR1B; ADCY1; CAMK2D; HSD3B4; CALM2; CACNA1H; CYP11B2; PRKCE; ATF6B

    PDE2A has several biochemical functions, for example, TPR domain binding, cAMP binding, cGMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE2A itself. We selected most functions PDE2A had, and list some proteins which have the same functions with PDE2A. You can find most of the proteins on our site.

    Function Related Protein
    TPR domain binding HSP90AA1; RAB8B; STUB1; HSP90AB1; PDE2A
    cGMP binding PDE11A; PDE2A; CNGA4; PRKG2; PDE6G; PRKG1; CNGA2; PDE10A; PDE5A; CNGA1
    cGMP-stimulated cyclic-nucleotide phosphodiesterase activity PDE10A; USB1; TDP2B; PDE2A; PDE11A
    calcium channel activity RYR1; TRPC7B; CACNG7A; TRPC1; TRPM2; TRPC7A; TRPV5; TRPV3; PANX1; CCDC109A
    cyclic-nucleotide phosphodiesterase activity PDE11A; USB1; TDP2B; PDE2A
    drug binding NR1I2; CHRM2; P2RX4; DAAM2; DHFR; Alb; IL2RA; PNP; GSTP2; ADRB2
    metal ion binding ZFP161; MMP14A; DDAH1; ZFP382; ADSSL; TRIM35-23; ZBED6; GTF3AB; HIVEP2; ACY3.2
    protein binding PLSCR1; EGR2; ORC3L; CDC42EP5; ANKRD17; H2AFY; SETDB2; SH3GL3; RBP4; TAF1B
    protein homodimerization activity OXCT1; SYNDIG1; ADAM10; STK25; BMP4; UPK1A; KYNU; PFKM; ACHE; ZBTB4

    PDE2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE2A.

    AIP; 3',5'-cyclic amp; metE; q7ard3_yerpe

    Suzuki, T; Ikari, K; et al. PADI4 and HLA-DRB1 Are Genetic Risks for Radiographic Progression in RA Patients, Independent of ACPA Status: Results from the IORRA Cohort Study. PLOS ONE 8:-(2013).
    Chao, YC; Cheng, CJ; et al. Guanylate cyclase-G, expressed in the Grueneberg ganglion olfactory subsystem, is activated by bicarbonate. BIOCHEMICAL JOURNAL 432:267-273(2010).

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