PDE3A involved in several pathways and played different roles in them. We selected most pathways PDE3A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
AMPD2; GUK1; PKMB; ENTPD5; ITPA; PNP5B; HDDC3; ENTPD2A.1; PPAT; PDE5AB |
| cGMP-PKG signaling pathway |
MYLK; ATP1B4; NPR1; MAP2K2; GNAI2; ATP1A3; RGS2; SLC25A5; CALM2; GUCY1B3 |
| cAMP signaling pathway |
CALM4; ACOX3; PIK3R5; CAMK2B; PDE4B; ROCK1; GLI1; VAV2; BAD; PIK3CA |
| Renin secretion |
ITPR1; ORAI1; Ren1; PDE1A; PRKG2; CLCA5; LOC100328615; PPP3CA; GNAQ; AGTR1A |
PDE3A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3A itself. We selected most functions PDE3A had, and list some proteins which have the same functions with PDE3A. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-AMP phosphodiesterase activity |
PDE4A; PDE3A; PDE4B; PDE1B; PDE4C; TDP2B; PDE8A; PDE7B; PDE7A; PDE4D |
| cAMP binding |
RAPGEF4; PDE11A; PRKAR2A; BVES; POPDC2; PDE2A; HCN2; CNMPD1; PRKAR2B; RAPGEF3 |
| cGMP-inhibited cyclic-nucleotide phosphodiesterase activity |
USB1; PDE3B; TDP2B; PDE3A |
| metal ion binding |
RFNG; LTN1; Car8; APTX; JAZF1A; CYB561D2; PHF23A; ZNF329; ZFP574; ZFP553 |
PDE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3A.
YWHAZ; Pcdh1; Cenpe; WDR62; HSPA5; BMH1; KIF11; Ccser2; CCDC88A; Cep44; Kctd5; Spred2; TUBA1C; Cenph; FBXO7
Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Proenca-Ferreira, R; Franco-Penteado, CF; et al. Increased adhesive properties of platelets in sickle cell disease: roles for alpha(IIb)beta(3)-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity. BRITISH JOURNAL OF HAEMATOLOGY 149:280-288(2010).
