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Official Full Name PDE3A phosphodiesterase 3A, cGMP-inhibited
Background Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
Synonyms PDE3A; phosphodiesterase 3A, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase A; CGI PDE; cyclic GMP-inhibited phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited; CGI-PDE; CGI-PDE A; CGI-PDE-A; FLJ37884
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His/GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE3A-018H Recombinant Human PDE3A Protein, His/GST-tagged Insect cell His/GST
    Human PDE3A-001HCL Recombinant Human PDE3A cell lysate Insect Cell N/A
    Human PDE3A-01H Recombinant Human PDE3A Protein, His/GST-tagged Insect Cell His/GST
    Human PDE3A-29931TH Recombinant Human PDE3A Wheat Germ N/A
    Human PDE3A-473H Recombinant Human PDE3A, GST-tagged, Active Sf9 Insect Cell GST
    Human PDE3A-7332H Recombinant Human PDE3A, His & GST tagged Insect Cell His/GST
    Rat Pde3a-301R Recombinant Rat Pde3a Protein, His/GST-tagged E.coli His/GST
    Rat PDE3A-4328R Recombinant Rat PDE3A Protein Mammalian Cell His
    Kit-1834 PDE3A Assay Kit N/A
    Kit-1835 PDE3A TR-FRET Assay Kit N/A

    pde3a involved in several pathways and played different roles in them. We selected most pathways pde3a participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with pde3a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism PDE6B; AMPD3B; POLE; URAD; NT5C3B; PRPS2; NPR2; GMPR2; ENPP1; AK9
    cGMP-PKG signaling pathway MEF2B; ATP1B4; PPP1CB; CREB3L1; ATF4; ATP2B1; INS; PRKG1; RHOA; SLC25A5
    cAMP signaling pathway MAPK1; VAV2; VAV3; NPR1; MAPK8; CREB3L3; FOS; GLI3; RRAS; FSHB
    Renin secretion ITPR1; CLCA3; GNAQ; ITPR3; GNAI1; CLCA5; GNAS; AQP1; PTGER4; AGTR1A

    pde3a has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by pde3a itself. We selected most functions pde3a had, and list some proteins which have the same functions with pde3a. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activity USB1; PDE4C; PDE3A; PDE4B; PDE8A; PDE4D; PDE7A; PDE1B; TDP2B; PDE8B
    cGMP-inhibited cyclic-nucleotide phosphodiesterase activity USB1; PDE3B; TDP2B; PDE3A
    metal ion binding ZNF711; HGS; KALRN; AMPD1; ZFY2; CYP46A1.1; TRAF4A; RNF121; AGAP2; RPS6KAL

    pde3a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pde3a here. Most of them are supplied by our site. Hope this information will be useful for your research of pde3a.

    YWHAZ; Pcdh1; Cenpe; WDR62; HSPA5; BMH1; KIF11; Ccser2; CCDC88A; Cep44; Kctd5; Spred2; TUBA1C; Cenph; FBXO7

    Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
    Proenca-Ferreira, R; Franco-Penteado, CF; et al. Increased adhesive properties of platelets in sickle cell disease: roles for alpha(IIb)beta(3)-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity. BRITISH JOURNAL OF HAEMATOLOGY 149:280-288(2010).

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