Creative BioMart to Join NIH Research Festival Biotech Vendor Exhibits 2024 | Sep. 25th, 2024 Learn More

PDE3A

Official Full Name

PDE3A phosphodiesterase 3A, cGMP-inhibited
Overview

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
Synonyms

PDE3A; phosphodiesterase 3A, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase A; CGI PDE; cyclic GMP-inhibited phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited; CGI-PDE; CGI-PDE A; CGI-PDE-A; FLJ37884;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Human
Rat

Source

E.coli
HEK293
Insect cell
Insect Cell
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PDE3A-7332H	Recombinant Human PDE3A, His & GST tagged	Insect Cell	His&GST		Inquiry
Human	PDE3A-29931TH	Recombinant Human PDE3A	Wheat Germ	Non	108 amino acids	Inquiry
Human	PDE3A-473H	Recombinant Human PDE3A, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	PDE3A-001HCL	Recombinant Human PDE3A cell lysate	Insect Cell	Non		Inquiry
Human	PDE3A-018H	Recombinant Human PDE3A Protein, His/GST-tagged	Insect cell	His&GST	669-1141	Inquiry
Human	PDE3A-01H	Recombinant Human PDE3A Protein, His/GST-tagged	Insect Cell	His&GST	669-1141	Inquiry
Rat	PDE3A-4328R	Recombinant Rat PDE3A Protein	Mammalian Cell	His		Inquiry
Rat	PDE3A-3988R-B	Recombinant Rat PDE3A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Pde3a-301R	Recombinant Rat Pde3a Protein, His/GST-tagged	E.coli	His&GST	Leu948~Leu1141	$298 / 10μg
Rat	PDE3A-3988R	Recombinant Rat PDE3A Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
	Kit-1834	PDE3A Assay Kit		Non		Inquiry
	Kit-1835	PDE3A TR-FRET Assay Kit		Non		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PDE3A involved in several pathways and played different roles in them. We selected most pathways PDE3A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	AK4;AMPD3B;URAD;PDE10A;NPR1A;NT5C1B;PDE7A;POLR2J3;DGUOK
cGMP-PKG signaling pathway	BDKRB2;GTF2I;GNA12;ATP2A3;NFATC4;MYLK4;ATP1A3;BAD;AGTR1B
cAMP signaling pathway	RELA;BAD;FSHB;LIPE;MAPK3;ATP1B4;PAK1;CREB3L3;CALML5
Renin secretion	CLCA4;NPR1;PPP3CA;PRKACA;CALML5;REN2;PLCB3;PTGER4;PPP3R1

PDE3A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3A itself. We selected most functions PDE3A had, and list some proteins which have the same functions with PDE3A. You can find most of the proteins on our site.

Function	Related Protein
3,5-cyclic-AMP phosphodiesterase activity	PDE1B;PDE8B;TDP2B;PDE4C;PDE3A;PDE7A;PDE8A;PDE4A;USB1
cAMP binding	RAPGEF3;CNMPD1;PRKAR2A;PDE10A;BVES;HCN2;RAPGEF4;CNGA2;CNGA4
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	TDP2B;PDE3B;USB1;PDE3A
metal ion binding	ZNF474;ADARB2;ZFP830;CYP2C70;ABO;GNAT2;PPM1G;LIG4;PLA2G12B

PDE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3A.

YWHAZ; Pcdh1; Cenpe; WDR62; HSPA5; BMH1; KIF11; Ccser2; CCDC88A; Cep44; Kctd5; Spred2; TUBA1C; Cenph; FBXO7

Research Area

Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).

Proenca-Ferreira, R; Franco-Penteado, CF; et al. Increased adhesive properties of platelets in sickle cell disease: roles for alpha(IIb)beta(3)-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity. BRITISH JOURNAL OF HAEMATOLOGY 149:280-288(2010).