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PDE3A

Official Full Name

PDE3A phosphodiesterase 3A, cGMP-inhibited
Background

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
Synonyms

PDE3A; phosphodiesterase 3A, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase A; CGI PDE; cyclic GMP-inhibited phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited; CGI-PDE; CGI-PDE A; CGI-PDE-A; FLJ37884;

Type:
Assay Kits
Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species :
Human
Rat

Source :
E.coli
HEK293
Insect cell
Insect Cell
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag :
GST
His
His (Fc)
Avi
His|GST
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
	Kit-1834	PDE3A Assay Kit		N/A	Inquiry
	Kit-1835	PDE3A TR-FRET Assay Kit		N/A	Inquiry
Human	PDE3A-018H	Recombinant Human PDE3A Protein, His/GST-tagged	Insect cell	His/GST	Inquiry
Human	PDE3A-001HCL	Recombinant Human PDE3A cell lysate	Insect Cell	N/A	Inquiry
Human	PDE3A-29931TH	Recombinant Human PDE3A	Wheat Germ	N/A	Inquiry
Human	PDE3A-7332H	Recombinant Human PDE3A, His & GST tagged	Insect Cell	His/GST	Inquiry
Human	PDE3A-473H	Recombinant Human PDE3A, GST-tagged, Active	Sf9 Insect Cell	GST	Inquiry
Human	PDE3A-01H	Recombinant Human PDE3A Protein, His/GST-tagged	Insect Cell	His/GST	Inquiry
Rat	Pde3a-301R	Recombinant Rat Pde3a Protein, His/GST-tagged	E.coli	His/GST	$298.00 / 10ug
Rat	PDE3A-3988R-B	Recombinant Rat PDE3A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	PDE3A-4328R	Recombinant Rat PDE3A Protein	Mammalian Cell	His	Inquiry
Rat	PDE3A-3988R	Recombinant Rat PDE3A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug

Involved Pathway
Protein Function
Interacting Protein
PDE3A Related Articles

PDE3A involved in several pathways and played different roles in them. We selected most pathways PDE3A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	POLR1B;NPR2;PDE11A;POLE2;ENPP1;NME7;ADSSL1;NT5C;AK4
cGMP-PKG signaling pathway	PPIF;PLCB4;MEF2B;SLC8A2;AKT2;PIK3R3;ATP1A4;ROCK2;CREB3L1
cAMP signaling pathway	HCAR3;HTR6;ORAI1;HCAR2;HCN4;CREB3L1;MAPK8;PDE4A;FXYD2
Renin secretion	CALM3;CALM1;PPP3R2;ACE;PLCB2;ITPR3;GNAS;CALM2;PLCB1

PDE3A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3A itself. We selected most functions PDE3A had, and list some proteins which have the same functions with PDE3A. You can find most of the proteins on our site.

Function	Related Protein
3,5-cyclic-AMP phosphodiesterase activity	PDE4B;PDE8A;PDE4D;PDE8B;TDP2B;USB1;PDE3A;PDE4C;PDE7B
cAMP binding	PRKAR2B;PDE4A;RAPGEF4;HCN2;HCN4;PDE10A;PRKAR2A;CNGA4;RAPGEF3
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	TDP2B;USB1;PDE3A;PDE3B
metal ion binding	CA4A;KLF11;CYP4V8;ZBTB5;ZNF550;GH1;ZNF10;NT5DC1;CHEK2

PDE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3A.

YWHAZ; Pcdh1; Cenpe; WDR62; HSPA5; BMH1; KIF11; Ccser2; CCDC88A; Cep44; Kctd5; Spred2; TUBA1C; Cenph; FBXO7

Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).

Proenca-Ferreira, R; Franco-Penteado, CF; et al. Increased adhesive properties of platelets in sickle cell disease: roles for alpha(IIb)beta(3)-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity. BRITISH JOURNAL OF HAEMATOLOGY 149:280-288(2010).