PDE3B
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Official Full Name
PDE3B phosphodiesterase 3B, cGMP-inhibited -
Overview
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B -
Synonyms
PDE3B;phosphodiesterase 3B, cGMP-inhibited;cGMP-inhibited 3,5-cyclic phosphodiesterase B;HcGIP1;CGIP1;CGI-PDE B;cyclic nucleotide phosphodiesterase;cyclic GMP-inhibited phosphodiesterase B;cGIPDE1
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Sf9 Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | PRKAG2A,PPP1CBL,PRKAR2AA,FLOT1,PRKAG1,PIK3R5,PPP1CC,TRIP10,PRKAA1,SHC2 |
| cAMP signaling pathway | ROCK1,GIPR,MAP2K2,GHRL,NFKBIA,PIK3CG,MAP2K1,VAV3,HTR1A,LIPE |
| cGMP-PKG signaling pathway | AGTR1A,MAP2K2,PLCB2,CALM4,GNAQ,AGTR1B,Adcy4,TRPC6,SLC25A6,ROCK2 |
| Renin secretion | GUCY1B3,PRKG2,PLCB3,CALM4,PPP3R2,PTGER4,PLCB2,AGTR1A,AQP1,GNAI1 |
| Progesterone-mediated oocyte maturation | MAPK13,RPS6KA1,HSP90AA1.2,PRKACA,CCNB2,CPEB1B,CDC27,PRKACBA,PKMYT1,RAF1A |
| Regulation of lipolysis in adipocytes | PIK3R1,AKT1,IRS1,Adcy4,PLIN1,PNPLA2,PTGS1,NPY1R,ABHD5,PRKACG |
| Purine metabolism | PDE1B,AMPD3B,NT5C3A,PDE6B,NUDT9,PDE6A,GUCY2E,POLR2GL,AMPD3,NT5C |
Protein Function
PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity,cGMP-inhibited cyclic-nucleotide phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cGMP-inhibited cyclic-nucleotide phosphodiesterase activity | PDE3A,TDP2B,USB1 |
| metal ion binding | CYB561D2,TRIM59,SH3RF3,CCDC71L,ZNF483,STK32B,ZNF830,ZBTB8B,HERC2,ZNF839 |
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE11A,PDE10A,PDE8B,PDE8A,PDE5A,PDE9A,PDE5AB,PDE6D,PDE4D |
| protein binding | USP6,AP1M2,LMF2,MUS81,HIST1H3G,RARB,NGLY1,PKM2,MPRIP,TAF3 |
| protein kinase B binding | TRAF6,CCDC88A,PINK1,BAD,RARA,ANKRD2,CDC37,APPL1,BCL10 |
Interacting Protein
PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.
RAPGEF3;PIK3R6;PIK3CG
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