PDE3B

  • Official Full Name

    PDE3B phosphodiesterase 3B, cGMP-inhibited
  • Overview

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
  • Synonyms

    PDE3B;phosphodiesterase 3B, cGMP-inhibited;cGMP-inhibited 3,5-cyclic phosphodiesterase B;HcGIP1;CGIP1;CGI-PDE B;cyclic nucleotide phosphodiesterase;cyclic GMP-inhibited phosphodiesterase B;cGIPDE1

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PDE3B-3492H Recombinant Human PDE3B protein, His-tagged E.coli Human His 321-670 aa
PDE3B-1526H Active Recombinant Human PDE3B, GST-tagged Sf9 Cells Human GST 654 aa-end
PDE3B-2849C Recombinant Chicken PDE3B Mammalian Cells Chicken His
PDE3B-29932TH Recombinant Human PDE3B Human Non 592-1112 a.a.
PDE3B-4329R Recombinant Rat PDE3B Protein Mammalian Cells Rat His
PDE3B-474H Recombinant Human PDE3B, GST-tagged, Active Sf9 Cells Human GST 654-end a.a.
Kit-1836 PDE3B Assay Kit I Non
Kit-1837 PDE3B Assay Kit II Non
PDE3B-3989R Recombinant Rat PDE3B Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PDE3B-3989R-B Recombinant Rat PDE3B Protein Pre-coupled Magnetic Beads HEK293 Rat
Pde3b-4744M Recombinant Mouse Pde3b Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
PDE3B-6370H Recombinant Human PDE3B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
PDE3B-742H Recombinant Human PDE3B Protein, MYC/DDK-tagged HEK293 Human DDK&Myc

    Involved Pathway

    PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathway GRIA2,ACOX3,NFATC1,GRIN2A,PAK1,CREB5,GHSR,PIK3R1,PDE3A,PIK3R2
    Regulation of lipolysis in adipocytes PLIN1,LOC100328615,PIK3CD,PRKG2,GNAI2,LIPE,INS,AKT2,INS1,PRKACA
    cGMP-PKG signaling pathway TRPC6,PRKG2,AGTR1B,AGTR1A,GNAI2,IRS4,CALM3,PLCB2,MAPK3,PPP1CA
    Insulin signaling pathway PPP1CBL,CALM4,FLOT2,RPS6KB2,HK1,INSRA,CALM3,INS1,CALM2A,G6PCA.2
    Progesterone-mediated oocyte maturation PIK3R2,CDC25A,MAPK14B,PRKACAA,CDC25B,CDK1,MAD2L1,GNAI2B,PIK3R3B,MAPK12A
    Purine metabolism ENTPD2A.1,PDE5AB,CANT1,ITPA,NUDT16,PDE4D,POLR3E,POLE4,PRPS1B,PDE6B
    Renin secretion PDE3A,ITPR1,CALM2,REN2,PLCB2,CLCA4,PRKACB,CLCA1,PRKACA,PRKACG

    Protein Function

    PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity,cGMP-inhibited cyclic-nucleotide phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-nucleotide phosphodiesterase activity PDE8A,PDE9A,PDE4D,PDE11A,PDE5A,PDE10A,PDE6D,PDE5AB,PDE8B
    protein binding PSG5,AUNIP,THY1,MID1,SYT6,TRIP10,UHMK1,MPDZ,POLRMT,BMF
    cGMP-inhibited cyclic-nucleotide phosphodiesterase activity USB1,TDP2B,PDE3A
    protein kinase B binding CCDC88A,PINK1,APPL1,RARA,TRAF6,CDC37,BAD,BCL10,ANKRD2
    metal ion binding ENTPD7,PHF23B,CLIP1,ZNF182,RIOK3,JAZF1B,WEE2,TATDN1,DDHD1B,ZNF280B

    Interacting Protein

    PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.

    RAPGEF3;PIK3R6;PIK3CG

    Resources

    References

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