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PDE3B

Official Full Name

PDE3B phosphodiesterase 3B, cGMP-inhibited
Overview

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
Synonyms

PDE3B; phosphodiesterase 3B, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase B; HcGIP1; CGIP1; CGI-PDE B; cyclic nucleotide phosphodiesterase; cyclic GMP-inhibited phosphodiesterase B; cGIPDE1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PDE3B-1526H	Active Recombinant Human PDE3B, GST-tagged	Sf9 Insect Cell	GST	654 aa-end	Inquiry
Human	PDE3B-474H	Recombinant Human PDE3B, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	PDE3B-29932TH	Recombinant Human PDE3B		N/A		Inquiry
Human	PDE3B-742H	Recombinant Human PDE3B Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	PDE3B-6370H	Recombinant Human PDE3B Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	PDE3B-3492H	Recombinant Human PDE3B protein, His-tagged	E.coli	His	321-670 aa	$319 / 25ug
Mouse	Pde3b-4744M	Recombinant Mouse Pde3b Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	PDE3B-4329R	Recombinant Rat PDE3B Protein	Mammalian Cell	His		Inquiry
Rat	PDE3B-3989R-B	Recombinant Rat PDE3B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PDE3B-3989R	Recombinant Rat PDE3B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	PDE3B-2849C	Recombinant Chicken PDE3B	Mammalian Cell	His		Inquiry
	Kit-1837	PDE3B Assay Kit II		N/A		Inquiry
	Kit-1836	PDE3B Assay Kit I		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	NUDT16;ADPRM;ADSSL1;PRUNE;POLA2;POLR2A;PRPS1B;PDE2A;PAPSS2A
cGMP-PKG signaling pathway	CALML5;SLC8A2;Adcy4;PDE3A;NPR2;MAP2K2;AKT1;GNAI3;PIK3R2
cAMP signaling pathway	MAPK1;MAP2K2;ACOX3;MC2R;GIPR;CALM2;CALM1;PLCE1;HCN2
Insulin signaling pathway	HRASA;PIK3R3A;TSC2;PIK3R2;AKT1;GRB2B;PYGMA;PPP1R3D;PRKCI
Progesterone-mediated oocyte maturation	BUB1;MAPK8A;ANAPC11;MAPK12B;CPEB4;SPDYB;GNAI2A;RAF1A;ADCY1A
Regulation of lipolysis in adipocytes	PRKACG;GNAI2;PNPLA2;LOC100328615;IRS2;GNAS;NPR1;PIK3CA;GNAI1
Renin secretion	CLCA5;GNAS;NPR1;CALML5;CALM1;REN2;CLCA4;GNAI1;ACE

PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.

Function	Related Protein
3,5-cyclic-nucleotide phosphodiesterase activity	PDE5AB;PDE8A;PDE10A;PDE8B;PDE9A;PDE5A;PDE11A;PDE4D;PDE6D
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity	PDE3B;TDP2B;USB1;PDE3A
metal ion binding	CYP4A14;Reln;DGCR8;XPA;ERCC2;PDE8A;TRIM55A;HENMT1;MT1HL1
protein binding	WASH1;PPP3CC;OCA2;FBXO4;UBE2O;FEZ1;GCNT1;SUN2;OOEP
protein kinase B binding	RARA;PINK1;ANKRD2;CDC37;CCDC88A;BCL10;PDE3B;BAD;TRAF6

PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.

RAPGEF3; PIK3R6; PIK3CG