• Official Full Name

    PDE3B phosphodiesterase 3B, cGMP-inhibited

  • Background

    Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
  • Synonyms

    PDE3B; phosphodiesterase 3B, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase B; HcGIP1; CGIP1; CGI-PDE B; cyclic nucleotide phosphodiesterase; cyclic GMP-inhibited phosphodiesterase B; cGIPDE1;
    • Type:
    • Assay Kits
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Kit-1836 PDE3B Assay Kit I N/A
    Kit-1837 PDE3B Assay Kit II N/A
    Chicken PDE3B-2849C Recombinant Chicken PDE3B Mammalian Cell His
    Human PDE3B-742H Recombinant Human PDE3B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PDE3B-6370H Recombinant Human PDE3B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PDE3B-29932TH Recombinant Human PDE3B N/A
    Human PDE3B-1526H Active Recombinant Human PDE3B (Active), GST-tagged Sf9 Insect Cell GST
    Human PDE3B-474H Recombinant Human PDE3B, GST-tagged, Active Sf9 Insect Cell GST
    Human PDE3B-3492H Recombinant Human PDE3B protein, His-tagged E.coli His
    Mouse Pde3b-4744M Recombinant Mouse Pde3b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PDE3B-3989R Recombinant Rat PDE3B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat PDE3B-3989R-B Recombinant Rat PDE3B Protein Pre-coupled Magnetic Beads HEK293
    Rat PDE3B-4329R Recombinant Rat PDE3B Protein Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolismPOLE3;ADKA;NT5C1BA;POLE2;GC3;PDE2A;ENTPD2;PDE8A;XDH
    cGMP-PKG signaling pathwayPLCB2;ROCK2;INSR;ATP1A3;AKT1;MEF2A;CALM2;SLC25A6;CREB5
    cAMP signaling pathwayCAMK2D;PIK3R3;NPY;DRD1A;MAPK8;ATP1A1;GIPR;TNNI3;MAPK3
    Insulin signaling pathwayFLOT2A;PHKG1;PRKAG3;AKT2L;CALM1B;HK3;PRKAG3B;PDPK1B;PPP1CB
    Progesterone-mediated oocyte maturationPIK3R3;PIK3R3A;RAF1A;CCNB1;PKMYT1;ANAPC7;BUB1;CPEB3;ANAPC13
    Regulation of lipolysis in adipocytesINSR;PIK3CB;PRKACA;PNPLA2;ABHD5;FABP4;GNAI3;IRS4;LOC100328615

    PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-nucleotide phosphodiesterase activityPDE3B;PDE11A;PDE8A;PDE8B;PDE5A;PDE9A;PDE6D;PDE4D;PDE10A
    cGMP-inhibited cyclic-nucleotide phosphodiesterase activityPDE3B;USB1;PDE3A;TDP2B
    metal ion bindingZFP367;CIZ1B;CAT;TGM2B;RPAIN;ZBTB12.1;CA15C;PTGS2;GYG1
    protein kinase B bindingRARA;APPL1;CCDC88A;BAD;PINK1;BCL10;TRAF6;ANKRD2;CDC37

    PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.


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