PDE4B involved in several pathways and played different roles in them. We selected most pathways PDE4B participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
GMPR2; PDE1B; POLR2A; ENPP4; POLR2G; PRPS1; FHIT; POLR2GL; NT5C; PNP5B |
| cAMP signaling pathway |
CALM3; MC2R; FXYD1; PTGER3; PRKACG; HHIP; ATP2B4; HTR1A; PIK3CB; AKT1 |
PDE4B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, gamma-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4B itself. We selected most functions PDE4B had, and list some proteins which have the same functions with PDE4B. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-AMP phosphodiesterase activity |
PDE4D; PDE4A; PDE1B; USB1; PDE8B; PDE4C; PDE7A; TDP2B; PDE4B; PDE3A |
| cAMP binding |
POPDC2; HCN2; RAPGEF3; CNMPD1; PDE11A; PDE3A; CNGA2; PDE4B; PRKAR2B; RAPGEF4 |
| gamma-tubulin binding |
TUBGCP5; BLOC1S2; BRCA2; DIXDC1; CEP57L1; PIFO; NME2; WASH; RAD51D; PDE4B |
| ion channel binding |
SNTA1; SLC14A2; KCNE1L; HSP90AB1; RIMS3; KCNH5; DIAPH1; VDAC1; GPD1L; SCN5A |
| metal ion binding |
XPNPEP2; MICAL2B; FDX1B; KDM8; MOBKL1A; ADCY3; SMAD9; ZFP518A; APLF; SP5 |
PDE4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4B.
DISC1; APOA1; ALB
Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Zwick, C; Held, G; et al. Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135:1207-1213(2009).
