PDE4B
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Official Full Name
PDE4B phosphodiesterase 4B, cAMP-specific -
Overview
Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling.The PDE4 enzyme belongs to a family of cAMPdependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP. Four genes (4A, 4B, 4C, and 4D) encode around 20 distinct isoform members of the PDE4 family. Each isoform is characterized by a unique Nterminal region -
Synonyms
PDE4B;phosphodiesterase 4B, cAMP-specific;DPDE4, phosphodiesterase 4B, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E4) , phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila);cAMP-specific 3,5-cyclic phosphodiesterase 4B;phosphodiesterase E4 dunce homolog (Drosophila);PDE32;dunce-like phosphodiesterase E4;cAMP-specific phosphodiesterase-4 B isoform;phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila);DPDE4;PDE4B5;PDEIVB;MGC126529;DKFZp686F2182
Recombinant Proteins
- Human
- Rat
- Chicken
- Rhesus macaque
- Mouse
- Insect Cells
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PDE4B involved in several pathways and played different roles in them. We selected most pathways PDE4B participated on our site, such as Purine metabolism,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | AKT2,RAP1B,ATP1B3,GHRL,NPY,PPP1CB,MAPK10,GRIA3,GIPR,HTR1B |
| Purine metabolism | NME2B.2,PNP,POLE,POLR3A,ZNRD1,PNP5A,GMPR,PNP6,PGM1,POLR1D |
Protein Function
PDE4B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity,cAMP binding,gamma-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4B itself. We selected most functions PDE4B had, and list some proteins which have the same functions with PDE4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | SKINT8,BMPR2,SEMG1,PLEKHF2,STS,BMPR1BA,ATP1A1A.1,POLD1,ZFP628,CXXC1A |
| gamma-tubulin binding | CEP57L1,BLOC1S2A,SPATC1,DIXDC1,FEZ1,CEP57,RACGAP1,NDN,TUBGCP4,BRCA2 |
| ion channel binding | KCNQ3,AKAP9,KCNB2,FXYD1,NOS1,TCAP,SNTA1,YWHAE,VDAC1,RIMS3 |
| cAMP binding | CNGA4,PDE4D,PRKAR1A,BVES,PDE2A,PRKAR2A,HCN4,PDE11A,HCN2,CNGA2 |
| 3,5-cyclic-AMP phosphodiesterase activity | PDE7B,PDE7A,PDE1B,PDE3A,PDE4C,PDE8A,TDP2B,PDE8B,PDE4D,USB1 |
Interacting Protein
PDE4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4B.
DISC1;APOA1;ALB
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References
- Zwick, C; Held, G; et al. Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135:1207-1213(2009).
- Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
