PDE4B Protein


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Official Full Name PDE4B phosphodiesterase 4B, cAMP-specific
Background Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling.The PDE4 enzyme belongs to a family of cAMPdependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP. Four genes (4A, 4B, 4C, and 4D) encode around 20 distinct isoform members of the PDE4 family. Each isoform is characterized by a unique Nterminal region
Synonyms PDE4B; phosphodiesterase 4B, cAMP-specific; DPDE4, phosphodiesterase 4B, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E4) , phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila); cAMP-specific 3,5-cyclic phosphodiesterase 4B; phosphodiesterase E4 dunce homolog (Drosophila); PDE32; dunce-like phosphodiesterase E4; cAMP-specific phosphodiesterase-4 B isoform; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); DPDE4; PDE4B5; PDEIVB; MGC126529; DKFZp686F2182
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His/GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE4B-1534H Recombinant Human PDE4B, His & GST tagged Insect Cell His/GST Inquiry
    Human PDE4B-30819TH Recombinant Human PDE4B, GST-tagged GST Inquiry
    Human PDE4B-476H Recombinant Human PDE4B, GST-tagged, Active Sf9 Insect Cell GST Inquiry
    Rat PDE4B-4331R Recombinant Rat PDE4B Protein Mammalian Cell His Inquiry
    Rhesus Macaque PDE4B-3348R Recombinant Rhesus monkey PDE4B Protein, His-tagged Mammalian Cell His Inquiry
    Chicken PDE4B-2947C Recombinant Chicken PDE4B Mammalian Cell His Inquiry
    Human PDE4B-621HCL Recombinant Human PDE4B cell lysate Insect Cell N/A Inquiry
    Human PDE4B-147H Recombinant Human PDE4B Protein, His/GST-tagged Insect cell His/GST Inquiry
    Human PDE4B-09H Recombinant Human PDE4B Protein, His/GST-tagged Insect Cell His/GST Inquiry
    Human PDE4B-1691H Recombinant Human PDE4B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human PDE4B-743H Recombinant Human PDE4B Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Mouse Pde4b-4746M Recombinant Mouse Pde4b Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Rat Pde4b-302R Recombinant Rat Pde4b Protein, His-tagged E.coli His Inquiry

    PDE4B involved in several pathways and played different roles in them. We selected most pathways PDE4B participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism GMPR2; PDE1B; POLR2A; ENPP4; POLR2G; PRPS1; FHIT; POLR2GL; NT5C; PNP5B
    cAMP signaling pathway CALM3; MC2R; FXYD1; PTGER3; PRKACG; HHIP; ATP2B4; HTR1A; PIK3CB; AKT1

    PDE4B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, gamma-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4B itself. We selected most functions PDE4B had, and list some proteins which have the same functions with PDE4B. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activity PDE4D; PDE4A; PDE1B; USB1; PDE8B; PDE4C; PDE7A; TDP2B; PDE4B; PDE3A
    gamma-tubulin binding TUBGCP5; BLOC1S2; BRCA2; DIXDC1; CEP57L1; PIFO; NME2; WASH; RAD51D; PDE4B
    ion channel binding SNTA1; SLC14A2; KCNE1L; HSP90AB1; RIMS3; KCNH5; DIAPH1; VDAC1; GPD1L; SCN5A
    metal ion binding XPNPEP2; MICAL2B; FDX1B; KDM8; MOBKL1A; ADCY3; SMAD9; ZFP518A; APLF; SP5

    PDE4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4B.


    Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
    Zwick, C; Held, G; et al. Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135:1207-1213(2009).

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