pde4b
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  • Official Full Name
  • PDE4B phosphodiesterase 4B, cAMP-specific
  • Background
  • Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling.The PDE4 enzyme belongs to a family of cAMPdependent PDEs that provide the major means of inactivating the key intracellular second messenger, cAMP. Four genes (4A, 4B, 4C, and 4D) encode around 20 distinct isoform members of the PDE4 family. Each isoform is characterized by a unique Nterminal region
  • Synonyms
  • PDE4B; phosphodiesterase 4B, cAMP-specific; DPDE4, phosphodiesterase 4B, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E4) , phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila); cAMP-specific 3,5-cyclic phosphodiesterase 4B; phosphodiesterase E4 dunce homolog (Drosophila); PDE32; dunce-like phosphodiesterase E4; cAMP-specific phosphodiesterase-4 B isoform; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); DPDE4; PDE4B5; PDEIVB; MGC126529; DKFZp686F2182
Cat.#:PDE4B-743HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDE4B Protein, MYC/DDK-tagged
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Cat.#:Pde4b-302RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pde4b Protein, His-tagged
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Cat.#:PDE4B-1534HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE4B, His & GST tagged
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Cat.#:PDE4B-30819THTag:GST
Source (Host):Species:Human
Product nameRecombinant Human PDE4B, GST-tagged
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Cat.#:PDE4B-476HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE4B, GST-tagged, Active
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Cat.#:PDE4B-4331RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDE4B Protein
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Cat.#:PDE4B-3348RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDE4B Protein, His-tagged
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Cat.#:PDE4B-2947CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDE4B
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Cat.#:PDE4B-621HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE4B cell lysate
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Involved Pathway

PDE4B involved in several pathways and played different roles in them. We selected most pathways PDE4B participated on our site, such as Purine metabolism, cAMP signaling pathway, Morphine addiction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
HPRT1; PDE1C; ADSSL; HDDC3; CECR1; GUCY2F; PNP; PDE7B; PPAT; GUCY1B3
cAMP signaling pathway
PPP1CB; CALML5; PIK3CD; CREB3L3; GABBR2; HCAR3; PDE4C; MLLT4; GLI1; ROCK2
Morphine addiction
GABRB3; GABRB1; GNG5; GRK4; GNB3; PDE8B; GABRQ; OPRM1; GABRA5; ARRB1

Protein Function

PDE4B has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, gamma-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4B itself. We selected most functions PDE4B had, and list some proteins which have the same functions with PDE4B. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-AMP phosphodiesterase activity
Related Protein PDE8B; PDE7B; PDE4C; PDE4B; PDE4A; USB1; PDE4D; PDE3A; PDE1B; TDP2B
Function cAMP binding
Related Protein POPDC2; PRKAR1B; CNGA2; PDE4B; PRKAR2B; HCN2; CNGA4; PDE10A; HCN4; PRKAR1A
Function gamma-tubulin binding
Related Protein TUBGCP2; NME2; RAD51D; NDN; OFD1; FEZ1; BLOC1S2; WASH; SPATC1; RACGAP1
Function ion channel binding
Related Protein KCNIP1; PDE4B; CALM2; FKBP1A; YWHAE; LRRK2; KCNIP2; ANK2; CALM; PRNP
Function metal ion binding
Related Protein ZBED6; ZIK1; KDM5D; PARP12B; CYP2P9; SP3; FIBCD1; ZC3H11A; ZBTB7C; ZNF652

Interacting Protein

PDE4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4B.
DISC1; APOA1; ALB

PDE4B Related Articles

Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Zwick, C; Held, G; et al. Spontaneous high-titered IgG antibody responses against BCL-2 in patients with aggressive lymphomas. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 135:1207-1213(2009).