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PDE4C

Official Full Name

phosphodiesterase 4C, cAMP-specific
Overview

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms

PDE4C; phosphodiesterase 4C, cAMP-specific; DPDE1, phosphodiesterase 4C, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E1); cAMP-specific 3,5-cyclic phosphodiesterase 4C; phosphodiesterase E1 dunce homolog (Drosophila); cAMP specific 3 5 cyclic phosphodiesterase 4C; DPDE 1; DPDE1; MGC126222; PDE 21; PDE 4C; PDE21; Phosphodiesterase 4C; Phosphodiesterase 4C cAMP specific; Phosphodiesterase E1 dunce homolog; Phosphodiesterase E1 dunce homolog Drosophila; Phosphodiesterase Type 4C; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
MYC
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PDE4C-1528H	Active Recombinant Human PDE4C, GST-tagged	Sf9 Insect Cell	GST	287 aa-end	Inquiry
Human	PDE4C-477H	Recombinant Human PDE4C, GST-tagged, Active	Sf9 Insect Cell	GST		Inquiry
Human	PDE4C-1600H	Recombinant Human PDE4C, GST-tagged	E.coli	GST	259-322aa	$319 / 25ug
Human	PDE4C-30820TH	Recombinant Human PDE4C		N/A		Inquiry
Human	PDE4C-3351HCL	Recombinant Human PDE4C 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PDE4C-2481H	Recombinant Human PDE4C protein, His-tagged	E.coli	His	28-91 aa	$319 / 25ug
Mouse	PDE4C-12555M	Recombinant Mouse PDE4C Protein	Mammalian Cell	His		Inquiry
Mouse	Pde4c-470M	Recombinant Mouse Pde4c Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	PDE4C-6585M	Recombinant Mouse PDE4C Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PDE4C-6585M-B	Recombinant Mouse PDE4C Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
	Kit-1840	PDE4C Assay Kit		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PDE4C Related Articles

PDE4C involved in several pathways and played different roles in them. We selected most pathways PDE4C participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PDE4C;ADPRM;NT5C3A;NT5C3B;ENTPD2A.1;POLR3GL;POLR2E;NT5C1A;GUCY2E
cAMP signaling pathway	PPP1CC;GRIA2;ATP1B3;GRIN2B;ATP1A4;GRIN3A;PAK1;PLD2;CALM1

PDE4C has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, drug binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4C itself. We selected most functions PDE4C had, and list some proteins which have the same functions with PDE4C. You can find most of the proteins on our site.

Function	Related Protein
3,5-cyclic-AMP phosphodiesterase activity	PDE8A;PDE7A;USB1;PDE4D;PDE4B;TDP2B;PDE3A;PDE4C;PDE7B
drug binding	ABP1;DCK;HMGCS1;SETD6;PYGM;CYP2D6;DAAM2;CHKA;NAMPT
metal ion binding	ZNF823;ZNF593;PPM1L;ITGA3;ALOX5A;ZNF608;RIMKLA;ZFP580;TNFRSF11A
protein binding	MBNL1;PLSCR3;TBC1D1;APLP2;HNRNPD;DMD;ATMIN;STRN;ZSCAN16

PDE4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4C here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4C.

Surmiak, M; Kaczor, M; et al. EXPRESSION PROFILE OF PROINFLAMMATORY GENES IN NEUTROPHIL-ENRICHED GRANULOCYTES STIMULATED WITH NATIVE ANTI-PR3 AUTOANTIBODIES. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 63:249-256(2012).

Curatola, AM; Xu, J; et al. Cyclic GMP protects endothelial progenitors from oxidative stress. ANGIOGENESIS 14:267-279(2011).