PDE4C involved in several pathways and played different roles in them. We selected most pathways PDE4C participated on our site, such as Purine metabolism, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE4C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
PKM2; AK1; POLR1D; NME2B.2; POLR3GL; Adcy4; PKMB; AK5; AMPD1; NT5C1A |
| cAMP signaling pathway |
ATP1B3; CNGA4; NPY; GRIN2D; BAD; GNAI2; PIK3R2; VAV1; PDE4B; PDE4C |
PDE4C has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, drug binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE4C itself. We selected most functions PDE4C had, and list some proteins which have the same functions with PDE4C. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-AMP phosphodiesterase activity |
PDE8B; PDE7B; PDE1B; TDP2B; PDE4C; PDE8A; PDE4D; PDE4B; PDE3A; PDE7A |
| drug binding |
SRP54B; FASN; PPARA; CHRM1; CHRNA3; DCK; PIGC; PPP3CA; DRD3; FOLR2 |
| metal ion binding |
MBLAC2; ZKSCAN14; SP8B; RAB11FIP3; CNOT6; ZSCAN18; CYP21A1; ZNF222; ZFP536; COL10A1 |
| protein binding |
OSTC; AKR1B10; BFAR; SMARCA5; TCEANC; PDCD6IP; GIPC2; MAP4K2; TEKT1; SALL1 |
PDE4C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE4C here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE4C.
Surmiak, M; Kaczor, M; et al. EXPRESSION PROFILE OF PROINFLAMMATORY GENES IN NEUTROPHIL-ENRICHED GRANULOCYTES STIMULATED WITH NATIVE ANTI-PR3 AUTOANTIBODIES. JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 63:249-256(2012).
Curatola, AM; Xu, J; et al. Cyclic GMP protects endothelial progenitors from oxidative stress. ANGIOGENESIS 14:267-279(2011).
