PDE8A
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Official Full Name
phosphodiesterase 8A -
Overview
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PDE8A;phosphodiesterase 8A;high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A;HsT19550;cAMP-specific cyclic nucleotide phosphodiesterase 8A;FLJ16150
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cells
- Wheat Germ
- Sf9 Cells
- HEK293
- His
- Non
- GST
- Avi
- Fc
Involved Pathway
PDE8A involved in several pathways and played different roles in them. We selected most pathways PDE8A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | PDE5A,GUCY1A3,GMPR2,PRPS1L1,AK3,ADA,NUDT2,POLR3E,NPR1A,POLD4 |
Protein Function
PDE8A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity,3,5-cyclic-nucleotide phosphodiesterase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE8A itself. We selected most functions PDE8A had, and list some proteins which have the same functions with PDE8A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE8B,PDE4D,PDE10A,PDE3B,PDE5A,PDE9A,PDE11A,PDE6D,PDE5AB |
| metal ion binding | ERI3,CD209,MBTD1,AMDHD1,VDRA,GLRX2,GTPBP8,GZF1,GALNT12,TRIM35-35 |
| 3,5-cyclic-AMP phosphodiesterase activity | PDE4B,TDP2B,PDE8B,USB1,PDE7B,PDE4C,PDE4A,PDE4D,PDE7A,PDE3A |
Interacting Protein
PDE8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE8A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE8A.
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