PDE8A

Official Full Name

phosphodiesterase 8A
Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms

PDE8A; phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A; HsT19550; cAMP-specific cyclic nucleotide phosphodiesterase 8A; FLJ16150;

Type:
Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species :
Human
Mouse
Rhesus Macaque
Zebrafish

Source :
E.coli
HEK293
Mammalian Cell
Sf9 Insect Cell
Wheat Germ

Tag :
GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PDE8A-1608H	Recombinant Human PDE8A, His-tagged	E.coli	His	$319.00 / 25ug
Human	PDE8A-30226TH	Recombinant Human PDE8A	Wheat Germ	N/A	Inquiry
Human	PDE8A-482H	Recombinant Human Phosphodiesterase 8A, GST-tagged, Active	Sf9 Insect Cell	GST	Inquiry
Human	PDE8A-3339HCL	Recombinant Human PDE8A 293 Cell Lysate	HEK293	N/A	Inquiry
Mouse	PDE8A-12564M	Recombinant Mouse PDE8A Protein	Mammalian Cell	His	Inquiry
Mouse	PDE8A-6592M	Recombinant Mouse PDE8A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	PDE8A-6592M-B	Recombinant Mouse PDE8A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	PDE8A-3352R	Recombinant Rhesus monkey PDE8A Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	PDE8A-3170R	Recombinant Rhesus Macaque PDE8A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	PDE8A-3170R-B	Recombinant Rhesus Macaque PDE8A Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	PDE8A-5117Z	Recombinant Zebrafish PDE8A	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

PDE8A involved in several pathways and played different roles in them. We selected most pathways PDE8A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PDE5A;NME2B.1;PRPS1L1;POLR2E;ADK;PDE3A;PNP5B;PDE1C;RRM1

PDE8A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE8A itself. We selected most functions PDE8A had, and list some proteins which have the same functions with PDE8A. You can find most of the proteins on our site.

Function	Related Protein
3,5-cyclic-AMP phosphodiesterase activity	USB1;PDE8B;TDP2B;PDE4D;PDE4C;PDE1B;PDE4A;PDE7A;PDE8A
3,5-cyclic-nucleotide phosphodiesterase activity	PDE9A;PDE8B;PDE4D;PDE5A;PDE8A;PDE11A;PDE5AB;PDE6D;PDE10A
metal ion binding	RUNX1T1;CYP4A12A;ZNF444;BMPR1A;ZFP93;ITGA4;DNLZ;MOBKL1A;STK24

PDE8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE8A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE8A.

msbA; sbcD