• Official Full Name

    phosphodiesterase 8A

  • Background

    The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PDE8A; phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A; HsT19550; cAMP-specific cyclic nucleotide phosphodiesterase 8A; FLJ16150;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human PDE8A-1608H Recombinant Human PDE8A, His-tagged E.coli His
    Human PDE8A-30226TH Recombinant Human PDE8A Wheat Germ N/A
    Human PDE8A-482H Recombinant Human Phosphodiesterase 8A, GST-tagged, Active Sf9 Insect Cell GST
    Human PDE8A-3339HCL Recombinant Human PDE8A 293 Cell Lysate HEK293 N/A
    Mouse PDE8A-12564M Recombinant Mouse PDE8A Protein Mammalian Cell His
    Mouse PDE8A-6592M Recombinant Mouse PDE8A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse PDE8A-6592M-B Recombinant Mouse PDE8A Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque PDE8A-3352R Recombinant Rhesus monkey PDE8A Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PDE8A-3170R Recombinant Rhesus Macaque PDE8A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque PDE8A-3170R-B Recombinant Rhesus Macaque PDE8A Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish PDE8A-5117Z Recombinant Zebrafish PDE8A Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    PDE8A involved in several pathways and played different roles in them. We selected most pathways PDE8A participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE8A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolismPDE5A;NME2B.1;PRPS1L1;POLR2E;ADK;PDE3A;PNP5B;PDE1C;RRM1

    PDE8A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE8A itself. We selected most functions PDE8A had, and list some proteins which have the same functions with PDE8A. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-AMP phosphodiesterase activityUSB1;PDE8B;TDP2B;PDE4D;PDE4C;PDE1B;PDE4A;PDE7A;PDE8A
    3,5-cyclic-nucleotide phosphodiesterase activityPDE9A;PDE8B;PDE4D;PDE5A;PDE8A;PDE11A;PDE5AB;PDE6D;PDE10A
    metal ion bindingRUNX1T1;CYP4A12A;ZNF444;BMPR1A;ZFP93;ITGA4;DNLZ;MOBKL1A;STK24

    PDE8A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE8A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE8A.

    msbA; sbcD

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