Recombinant Human Phosphodiesterase 8A, GST-tagged, Active

Cat.No. : PDE8A-482H
Product Overview : Recombinant Full-length human PDE8A was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 120 kDa.
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Cat. No. : PDE8A-482H
Description : PDE8A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE8A is a high-affinity cAMP-specific PDE expressed in a variety of tissues such as ovary and testis. PDE8A plays an important role in many biological processes, including T-cell activation, testosterone production, adrenocortical hyperplasia, and thyroid function. Targeted mutation in the PDE8A gene in Leydig cells show sensitivity in the action of LH in terms of testosterone production. PDE8A, through its PAS domain, can bind with IkappaB proteins in a region containing their ankyrin repeats. The association of PDE8A with IkappaB greatly enhanced the enzyme activity this enzyme.
Source : Sf9 insect cells using baculovirus.
Sequence : Full length.
Applications : PDE Assay.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : PDE8A phosphodiesterase 8A [ Homo sapiens ]
Synonyms : PDE8A; phosphodiesterase 8A; FLJ16150; HsT19550; OTTHUMP00000192898; cAMP-specific cyclic nucleotide phosphodiesterase 8A; high-affinity cAMP-specific and IBMX-insensitive 3",5"-cyclic phosphodiesterase 8A; EC 3.1.4.17
Gene ID : 5151
mRNA Refseq : NM_002605
Protein Refseq : NP_002596
MIM : 602972
UniProt ID : O60658
Chromosome Location : 15q25.3
Pathway : Progesterone-mediated oocyte maturation; Purine metabolism
Function : 3",5"-cyclic-AMP phosphodiesterase activity; hydrolase activity; manganese ion binding; magnesium ion binding; two-component response regulator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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