PDE8A-482H
Optional Service: Optional requirements on this protein
Product Overview :
Recombinant Full-length human PDE8A was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 120 kDa.
Description :
PDE8A is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE8A is a high-affinity cAMP-specific PDE expressed in a variety of tissues such as ovary and testis. PDE8A plays an important role in many biological processes, including T-cell activation, testosterone production, adrenocortical hyperplasia, and thyroid function. Targeted mutation in the PDE8A gene in Leydig cells show sensitivity in the action of LH in terms of testosterone production. PDE8A, through its PAS domain, can bind with IkappaB proteins in a region containing their ankyrin repeats. The association of PDE8A with IkappaB greatly enhanced the enzyme activity this enzyme.
Source :
Sf9 insect cells using baculovirus.
Sequence :
Full length.
Applications :
PDE Assay.
Storage And Stability :
Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.