Recombinant Human PDE8A

Cat.No. : PDE8A-30226TH
Product Overview : Recombinant fragment, corresponding to amino acids 32-121 of Human PDE8A, with an N-terminal proprietary tag, predicted MWt 35.53 kDa
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Description : The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein length : 90 amino acids
Molecular Weight : 35.530kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : RLPQGQKTAALPRTRGAGLLESELR DGSGKKVAVADVQFGPMRFHQDQLQ VLLVFTKEDNQCNGFCRACEKAGFK CTVTKEAQAVLACFL
Sequence Similarities : Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.Contains 1 PAC (PAS-associated C-terminal) domain.Contains 1 PAS (PER-ARNT-SIM) domain.
Gene Name : PDE8A phosphodiesterase 8A [ Homo sapiens ]
Official Symbol : PDE8A
Synonyms : PDE8A; phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A; HsT19550;
Gene ID : 5151
mRNA Refseq : NM_001243137
Protein Refseq : NP_001230066
MIM : 602972
Uniprot ID : O60658
Chromosome Location : 15q25.3
Pathway : G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem;
Function : 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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