- Human(4)
- Mouse(2)
- Rhesus Macaque(2)
- Zebrafish(1)
Recombinant Human PDE8A
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Cat.No. : | PDE8A-30226TH Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant fragment, corresponding to amino acids 32-121 of Human PDE8A, with an N-terminal proprietary tag, predicted MWt 35.53 kDa |
Description : | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 90 amino acids |
Molecular Weight : | 35.530kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | RLPQGQKTAA LPRTRGAGLL ESELRDGSGK KVAVADVQFG PMRFHQDQLQ VLLVFTKEDN QCNGFCRACE KAGFKCTVTK EAQAVLACFL |
Sequence Similarities : | Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.Contains 1 PAC (PAS-associated C-terminal) domain.Contains 1 PAS (PER-ARNT-SIM) domain. |
Gene Name : | PDE8A phosphodiesterase 8A [ Homo sapiens ] |
Official Symbol : | PDE8A |
Synonyms : | PDE8A; phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3,5-cyclic phosphodiesterase 8A; HsT19550; |
Gene ID : | 5151 |
mRNA Refseq : | NM_001243137 |
Protein Refseq : | NP_001230066 |
MIM : | 602972 |
Uniprot ID : | O60658 |
Chromosome Location : | 15q25.3 |
Pathway : | G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; |
◆ Recombinant Protein
PDE8A-6592M | Recombinant Mouse PDE8A Protein, His (Fc)-Avi-tagged | +Inquiry |
PDE8A-3170R | Recombinant Rhesus Macaque PDE8A Protein, His (Fc)-Avi-tagged | +Inquiry |
PDE8A-482H | Recombinant Human Phosphodiesterase 8A, GST-tagged, Active | +Inquiry |
PDE8A-12564M | Recombinant Mouse PDE8A Protein | +Inquiry |
PDE8A-5117Z | Recombinant Zebrafish PDE8A | +Inquiry |
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◆ Lysates
PDE8A-3339HCL | Recombinant Human PDE8A 293 Cell Lysate | +Inquiry |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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