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Official Full Name protein disulfide isomerase family A, member 3
Background This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]
Synonyms PDIA3; protein disulfide isomerase family A, member 3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n; protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; epididymis secretory protein Li 269; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 93n;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDIA3-03H Recombinant Human PDIA3 protein E.coli N/A
    Human PDIA3-120H Recombinant Human PDIA3, His-tagged E.coli His
    Human PDIA3-1615H Recombinant Human PDIA3, GST-tagged E.coli GST
    Human PDIA3-186H Recombinant Human PDIA3 Protein, His-tagged HEK293 His
    Human PDIA3-20H Recombinant Human PDIA3 protein, His-tagged E.coli His
    Human PDIA3-26230TH Recombinant Human PDIA3, His-tagged E.coli His
    Human PDIA3-3331HCL Recombinant Human PDIA3 293 Cell Lysate HEK293 N/A
    Human PDIA3-5933H Recombinant Human PDIA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pdia3-1066M Recombinant Mouse Pdia3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse PDIA3-12577M Recombinant Mouse PDIA3 Protein Mammalian Cell His
    Mouse PDIA3-32M Recombinant Mouse PDIA3 Protein, His-tagged E.coli His
    Rat PDIA3-4344R Recombinant Rat PDIA3 Protein Mammalian Cell His
    Rhesus Macaque PDIA3-3358R Recombinant Rhesus monkey PDIA3 Protein, His-tagged Mammalian Cell His
    Chicken PDIA3-5686C Recombinant Chicken PDIA3 Mammalian Cell His
    Zebrafish PDIA3-7874Z Recombinant Zebrafish PDIA3 Mammalian Cell His

    pdia3 involved in several pathways and played different roles in them. We selected most pathways pdia3 participated on our site, such as Protein processing in endoplasmic reticulum, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with pdia3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum MAP2K7; CUL1A; SEL1L2; UBQLN1; NSFL1C; HSPBP1; SEC24C; UBQLN3; DNAJB1B; MAN1A1
    Antigen processing and presentation KIR2DL4; HLA-DRB4; HLA-G; KIR2DL3; HSP90AA1; HLA-DQA1; LGMN; HLA-DRB3; HLA-DRB5; RFXAP

    pdia3 has several biochemical functions, for example, cysteine-type endopeptidase activity, disulfide oxidoreductase activity, phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by pdia3 itself. We selected most functions pdia3 had, and list some proteins which have the same functions with pdia3. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase activity Casp3; PSD; USP15; USP31; USP1; USP45; CTSH; CASP8L1; USP9X; USP3
    disulfide oxidoreductase activity COIL; GRX2; DNAJC10; TXNL1; PDIA3; PDIA2; TMX1; TXN
    phospholipase C activity PLCE1; PLCB3; PLCH2; PLCL1; PLCB2; ADORA1; PDIA3; PLCG2; PLCB4; PLCG1
    poly(A) RNA binding NPM1; DBR1; RPS27A; EXOSC6; STAU2; SCAF4; RPS17L; RBM15; ADAR; TBL2
    protein binding CDX4; ZNF286A; SPHK2; TRIM55; UACA; FRK; PTK2; ZBTB16; IFNGR1; METTL1
    protein disulfide isomerase activity TMX3; PDIA2; QSOX2; PIGK; ERP44; TMX4; ERO1LB; P4HB; ITGB3; PDIA3

    pdia3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pdia3 here. Most of them are supplied by our site. Hope this information will be useful for your research of pdia3.

    ERO1L; CLU; STIM1; APP; TAP1; env; Edem3; AGRN

    Doroudi, M; Schwartz, Z; et al. Membrane-mediated actions of 1,25-dihydroxy vitamin D3: A review of the roles of phospholipase A(2) activating protein and Ca2+/calmodulin-dependent protein kinase II. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 147:81-84(2015).
    Nemere, I; Garbi, N; et al. The 1,25D(3)-MARRS Receptor/PDIA3/ERp57 and Lifespan. JOURNAL OF CELLULAR BIOCHEMISTRY 116:380-385(2015).

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