PDP2
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Official Full Name
pyruvate dehyrogenase phosphatase catalytic subunit 2 -
Overview
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. -
Synonyms
PDP2;pyruvate dehyrogenase phosphatase catalytic subunit 2;[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial;KIAA1348;PPM2C2;protein phosphatase 2C;magnesium dependent;catalytic subunit 2;mitochondrial;[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2;MSP46;PDP 2;PDP2_HUMAN;PDPC 2;Pyruvate dehydrogenase phosphatase 2;Pyruvate dehydrogenase phosphatase catalytic subunit 2;pyruvate dehydrogenase phosphatase isoenzyme 2;Pyruvate dehydrogenase phosphatase, catalytic subunit 2;protein phosphatase 2C, magnesium-dependent, catalytic subunit 2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- His
- T7
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
PDP2 involved in several pathways and played different roles in them. We selected most pathways PDP2 participated on our site, such as Metabolism,Pyruvate metabolism,Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| The citric acid (TCA) cycle and respiratory electron transport | FAM36A,C20orf7,NDUFAF6,ATP5L,COX16,BRP44,ETFB,UCP2,TIMMDC1,PDK3 |
| Pyruvate metabolism | ALDH2,ME2,PKM2,ALDH9A1,ALDH2.1,PDK2,ackA,MDH1,ME1,ALDH7A1 |
| Regulation of pyruvate dehydrogenase (PDH) complex | PDK3B,PDK2B,PDK3,PDK4,PDP1,PDPR,PDK2 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | SLC16A8,PDK3,PDK2,PDPR,PDK4,BRP44,SLC16A1,PDK3B,PDK2B,D2HGDH |
| Metabolism | CYP2U1,SIN3B,ETFDH,OAZ3,DIO2,COX6C,ARV1,HIBADH,FTCD,SULT2ST2 |
Protein Function
PDP2 has several biochemical functions, for example, [pyruvate dehydrogenase (lipoamide)] phosphatase activity,metal ion binding,protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDP2 itself. We selected most functions PDP2 had, and list some proteins which have the same functions with PDP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| [pyruvate dehydrogenase (lipoamide)] phosphatase activity | PDP1 |
| protein serine/threonine phosphatase activity | PP2D1,PPM1L,PPP6C,PPP1R15B,PPEF2,PPP4C,PTEN,CDC14C,PPM1AB,ILKAP |
| metal ion binding | FAM20B,RUNX1T1,SALL2,MYSM1,ZIC2A,ASPA,KLF2A,CLCNKB,TRIM35-20,FGD3 |
Interacting Protein
PDP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDP2.
Resources
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References
- Belykh, LB; Skripov, NI; et al. The Catalytic Properties of Pd Nanoparticles Modified by Phosphorus in Liquid-phase Hydrogenation of o-chloronitrobenzene. CURRENT NANOSCIENCE 11:175-185(2015).
- Rellinger, EJ; Romain, C; et al. Silencing Gastrin-Releasing Peptide Receptor Suppresses Key Regulators of Aerobic Glycolysis in Neuroblastoma Cells. PEDIATRIC BLOOD & CANCER 62:581-586(2014).
