PFKM
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Official Full Name
Fructose-6-Phosphate Kinase
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Overview
Phosphofructokinase catalyzes the irreversible conversion of fructose 6 phosphate to fructose 1,6 bisphosphate. Mammalian PFK is a complex isozyme consisting of 3 subunits: muscle (M), liver (L), and platelet (P). Each subunit is encoded by a separate structural locus on chromosomes 1(M), 21(L), and 10(P). PFKL is the major form in liver and kidney while only M type PFK isozyme is expressed in mature muscle; therefore, muscle contains only homotetramers of M subunits. Erythrocytes contain both L and M subunits, and these randomly tetramerize to form M4, L4, and 3 additional hybrid forms of the holoenzyme. -
Synonyms
Fructose-6-Phosphate Kinase; 6 Phosphofructokinase Muscle; EC 2.7.1.11; GSD7; MGC8699; PFKA; PFKL; PFKM; PFKP; PFKX; Phosphofructo 1 Kinase Isozyme A; Phosphofructokinase 1; Phosphofructokinase M; Phosphofructokinase muscle; Phosphofructokinase muscle type; Phosphofructokinase polypeptide X; Phosphohexokinase; 6-phosphofructokinase; phosphofructokinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
PFKM involved in several pathways and played different roles in them. We selected most pathways PFKM participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | PKLR;HKDC1;ALDH3B1;LDHBA;ALDOAA;AKR1A1;LDHA;LDHC;FBP1A |
Pentose phosphate pathway | ALDOA;PRPS1;H6PD;RBKS;TALDO1;ALDOC;PRPS1B;GPIA;GPI1 |
Fructose and mannose metabolism | TPI1A;PFKFB4;ENOSF1;MPI;FPGT;AKR1B7;GMPPA;HK3;C12orf5 |
Galactose metabolism | AKR1B1;G6PC;PFKM;G6PCA.1;UGP2B;GALK1;UGP2A;AKR1B7;AKR1B8 |
Metabolic pathways | SDHDA;SEPHS2;HAO1;PIP5K1AB;PIP5K1AA;PRPS2;TST;HAL;MT-ND4 |
Carbon metabolism | PDHA2;ACSS1;PCCA;AGXT;SDHD;HIBCH;GLUD2;PFKP;MDH1AA |
Biosynthesis of amino acids | PFKL;PGAM1A;IDH3G;OTC;AADAT;NAGS;CPS1;ALDOAA;TALDO1 |
RNA degradation | EXOSC10;TTC37;DCP1A;TOB1B;groL;DCPS;PABPC1;XRN2;PABPC4 |
AMPK signaling pathway | IGF1R;ADIPOR2;IGF1;RAB2A;RPTOR;CCNA1;INS1;TBC1D1;RAB14 |
Central carbon metabolism in cancer | TRP53;NTRK3;FLT3;PGAM2;MTOR;NRAS;PDGFRA;SIRT3;TP53 |
PFKM has several biochemical functions, for example, 6-phosphofructokinase activity, ATP binding, fructose binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKM itself. We selected most functions PFKM had, and list some proteins which have the same functions with PFKM. You can find most of the proteins on our site.
Function | Related Protein |
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6-phosphofructokinase activity | PFKMB;PFKM;PFKMA;PFKL;PFKP;PFKLB |
ATP binding | KIF2A;AARS;NWD1;ACVR1C;MASTL;MYO1EB;HSPA1L;MAPK8;CDK10 |
fructose binding | PFKL;ALDOA;PFKM;ALDOB |
identical protein binding | SHANK1;STK10;ALAD;CLDN11;C1QTNF2;PPP5C;APAF1;DPY30;VPS41 |
kinase binding | CHP;DLG1;TENC1;PRKAA1;CEBPA;PRDX3;JAKMIP2;PER3;EMP2 |
metal ion binding | ZNF644A;ENOPH1;ZHX3;CD209A;ZFP598;THAP4;SMYD1A;ZFP750;RASA3 |
protein C-terminus binding | RABAC1;NCF2;HPCAL4;SIRT1;LIG4;HSPB7;PRKAA1;PABPC1;CTBP1 |
protein binding | LCE3E;SH2D1B;SFRP5;ZNF580;ARRB2;SDC1;PPIAL4A;SEC22A;CDCA7L |
protein homodimerization activity | PRPS1L1;ACTN2;ASNS;CTBP2;LRP4;TPD52;ABCD1;CD200;MZF1 |
PFKM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKM here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKM.
PFKL; SIAH1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; MCC; NDUFB2; Hoxa1; MAPK3; PDGFRL; SFRP4
- Q&As
- Reviews
Q&As (5)
Ask a questionDrug interactions involving PFKM-related therapies have not been extensively studied, but caution should be exercised in combination with other medications.
Yes, PFKM deficiency is an autosomal recessive disorder, meaning it can be passed on from both parents.
Targeting PFKM with small molecule inhibitors or gene therapies is being explored as potential treatment strategies.
PFKM levels have been studied as potential biomarkers for cancer and metabolic disorders, but more research is needed for clinical application.
Research suggests that PFKM may play a role in cardiac energy metabolism and could be implicated in cardiovascular diseases.
Customer Reviews (3)
Write a reviewAs a researcher, utilizing PFKM protein in trials offers numerous advantages that contribute to the successful completion of experiments and the acquisition of valuable data.
manufacturers offer customization options, such as alternative conjugation methods or tailored formulations, allowing researchers to optimize PFKM protein to their specific experimental needs.
This ensures the consistency and reproducibility of experimental results, promoting confidence in the obtained data.
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