PHKA2
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Official Full Name
phosphorylase kinase, alpha 2 (liver) -
Overview
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9A, also known as X-linked liver glycogenosis. Alternatively spliced transcript variants have been reported, but the full-length nature of these variants has not been determined. -
Synonyms
PHKA2;phosphorylase kinase, alpha 2 (liver);PHK, PYK;phosphorylase b kinase regulatory subunit alpha, liver isoform;phosphorylase kinase alpha-subunit;phosphorylase kinase alpha L subunit;phosphorylase b kinase regulatory subunit alpha liver isoform
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PHKA2-1684H | Recombinant Human PHKA2, His-tagged | E.coli | Human | His | 886-1235aa | |
| PHKA2-1346HCL | Recombinant Human PHKA2 cell lysate | Human | Non |
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| Phka2-452M | Recombinant Mouse Phka2 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PHKA2-5072H | Recombinant Human PHKA2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
PHKA2 involved in several pathways and played different roles in them. We selected most pathways PHKA2 participated on our site, such as Calcium signaling pathway,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | CAMK2B1,TACR3,PLCE1,PLCZ1,BDKRB1,STIM2,PLCD1B,PTGER3,CD38,HTR5A |
| Insulin signaling pathway | FBP1B,EXOC7,PRKAA1,PCK1,PIK3CD,SH2B2,PYGB,PHKG1,PRKAG1,FOXO1A |
Protein Function
PHKA2 has several biochemical functions, for example, calmodulin binding,phosphorylase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKA2 itself. We selected most functions PHKA2 had, and list some proteins which have the same functions with PHKA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | PLCB1,MARCKSL1A,EEF2K,CALD1B,CDK5RAP2,CAMKK1,SRY,CNN2,USP6,TRPV6 |
| phosphorylase kinase activity | PHKG1A,PHKG2,PHKB,PHKG1,PHKG1B |
Interacting Protein
PHKA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKA2.
PHKG2;Ndc80;SMAD9;Mtx2;ARRB2;BAG6;Rmdn3;Ppp1r3b;Oxnad1;GOLT1B
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References
- Wang, X; Chen, YP; et al. Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes. JOURNAL OF DIABETES RESEARCH :-(2015).
- Lai, YH; Lin, CC; et al. Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors. GENE THERAPY 22:155-162(2015).
