pi4ka
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  • Official Full Name
  • phosphatidylinositol 4-kinase, catalytic, alpha
  • Background
  • This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene.
  • Synonyms
  • PI4KA; phosphatidylinositol 4-kinase, catalytic, alpha; PIK4CA; phosphatidylinositol 4-kinase alpha; PI4K ALPHA; pi4K230; PI4-kinase alpha; ptdIns-4-kinase alpha; phosphatidylinositol 4-kinase 230; phosphatidylinositol 4-kinase, type III, alpha; PI4K-ALPH
Cat.#:PI4KA-117HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PI4KA, GST-tagged
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Cat.#:PI4KA-161HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PI4KA protein, GST-tagged, Active
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Cat.#:PI4KA-1700HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PI4KA, His-tagged
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Cat.#:PI4KA-30331THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PI4KA
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Cat.#:PI4KA-4439RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PI4KA Protein
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Cat.#:PI4KA-3207HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PI4KA 293 Cell Lysate
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Involved Pathway

PI4KA involved in several pathways and played different roles in them. We selected most pathways PI4KA participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PI4KA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PLCB4; INPP4B; PLCD1; PLCD3; MTMR1A; IMPAD1; IMPA2; ITPK1A; PIP4K2C; PIKFYVE
Metabolic pathways
NDST2; P4HA1A; PANK2; PLD1; NDUFA9A; PI4KAA; UGT1AB; CHPT1; CES1; GLCEB
Phosphatidylinositol signaling system
PRKCG; PIP5K1BA; PIK3C3; PTENA; PLCE1; PRKCB; CALM; PLCB1; CDS1; INPP5A

Protein Function

PI4KA has several biochemical functions, for example, 1-phosphatidylinositol 4-kinase activity, ATP binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PI4KA itself. We selected most functions PI4KA had, and list some proteins which have the same functions with PI4KA. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol 4-kinase activity
Related Protein PI4KA; PI4K2A; PI4KAA; PI4K2B; PI4KB; PI4KAB
Function ATP binding
Related Protein STYK1; DYRK1A; NMNAT2; KIF20B; NIM1K; PANK2; DNAH14; PKDCC; ERBB3B; DDX6
Function protein binding
Related Protein C10orf33; SUGP1; ERGIC1; MAD2L1BP; C12orf68; NIPAL3; DNM1L; KIR2DL3; ETF1; FMR1

Interacting Protein

PI4KA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI4KA here. Most of them are supplied by our site. Hope this information will be useful for your research of PI4KA.
q99ib8-pro_0000045602; p27958-pro_0000037576; VCAM1; q9wmx2-pro_0000037551; TNNT1; purL; dnaJ2