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PIAS1

Official Full Name

protein inhibitor of activated STAT, 1
Overview

This gene encodes a member of the mammalian PIAS (protein inhibitor of activated STAT-1 (signal transducer and;activator of transcription-1)) family. This member contains a putative zinc-binding motif and a highly acidic region.;It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box;polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor;transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.
Synonyms

PIAS1; protein inhibitor of activated STAT, 1; DDXBP1, DEAD/H (Asp Glu Ala Asp/His) box binding protein 1; E3 SUMO-protein ligase PIAS1; GBP; GU/RH II; zinc finger; MIZ type containing 3; ZMIZ3; gu-binding protein; AR interacting protein; DEAD/H box-bind;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PIAS1-673H	Recombinant Human PIAS1, GST-tagged	E.coli	GST		Inquiry
Human	PIAS1-1865H	Recombinant Human PIAS1 protein, His & T7-tagged	E.coli	His/T7	Glu409~Pro645 (Accession # O75925)	Inquiry
Human	PIAS1-3205HCL	Recombinant Human PIAS1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	PIAS1-12768M	Recombinant Mouse PIAS1 Protein	Mammalian Cell	His		Inquiry
Mouse	PIAS1-6718M	Recombinant Mouse PIAS1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PIAS1-6718M-B	Recombinant Mouse PIAS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	PIAS1-3421R	Recombinant Rhesus monkey PIAS1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PIAS1-3239R-B	Recombinant Rhesus Macaque PIAS1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	PIAS1-3239R	Recombinant Rhesus Macaque PIAS1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	PIAS1-3103C	Recombinant Chicken PIAS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PIAS1 Related Articles
PIAS1 Related Signal Pathway

PIAS1 involved in several pathways and played different roles in them. We selected most pathways PIAS1 participated on our site, such as Ubiquitin mediated proteolysis, Jak-STAT signaling pathway, Hepatitis C, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	UBE2D2;PIAS4A;UBE2Z;BIRC2;UBE2A;BIRC7;MAP3K1;SOCS1A;NHLRC1
Jak-STAT signaling pathway	SOCS3B;LEPR;LIFR;CRFB4;IL6R;IL6ST;BCL2;CCND3;Gh
Hepatitis C	SCARB1;IRF3;IFNA14;CLDN1;IKBKE;EIF2AK4;PPP2R1A;CLDN9;CLDN17

PIAS1 has several biochemical functions, for example, DNA binding, SUMO ligase activity, androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS1 itself. We selected most functions PIAS1 had, and list some proteins which have the same functions with PIAS1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	WRNIP1;JUNBB;PRRX1A;DLX3B;TRP53;SPO11;HDGF;SMARCB1A;SMAD3A
SUMO ligase activity	PIAS1;PIAS4;PIAS2
androgen receptor binding	Ar;PIAS2;TRIM68;RB1;NCOA4;FOXH1;KDM3A;PARK7;EP300
enzyme binding	ATG3;NOXA1;CDK19;EGFR;ARPC4;YES1;CDC20;RXRA;PDCD2
ligase activity	RNF125;MEX3C;UBR5;RNF13;UBE2KA;BIRC3;RNF126;TTLL11;RNF25
protein binding	SERP2;RNF165;PITPNM3;COX8A;NCF1;C10orf137;NAB2;ZC3H11A;CARF
transcription coactivator activity	MCIN;GTF2A2;LPIN1;TFDP1;TAF6L;PRMT2;ACTL6A;UTF1;UBE2L3
transcription corepressor activity	MAP3K10;MXD4;TFCP2L1;KCNIP3;BATF3;ATF3;CBFA2T2;DRAP1;HEYL
transcription factor binding	FHL2;GATA3;TCF12;REST;E2F5;HEY2;TRIM11;FOXA3;CDKN2A
ubiquitin protein ligase binding	SPOP;TRIM28;UBE2J1;OTUB1;BID;MDM2;EIF4E2;UBE2G1;TRAF2
zinc ion binding	OAS2;ZGLP1;ADAMTS1;ZNF185;ZZEF1;RNF169;ZNRF2B;HRG;RXRBB

PIAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS1.

TP53; MBD1; SMAD4; PRDM1; CASP8AP2; PASK; PIAS2; E1; E1; PTPN1

Ying, HY; Su, ST; et al. SUMOylation of Blimp-1 is critical for plasma cell differentiation. EMBO REPORTS 13:631-637(2012).