Recombinant Human PIAS1, GST-tagged

• Cat.No.: PIAS1-673H

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: PIAS1 is a SUMO E3 ligase with specificity for a range of different substrates including p53, Hdm2, transcription factors, androgen receptors and co-repressor proteins.
• Source/Host: E.coli.
• Biological Activity: Exhibits SUMO modification activity in vitro.
• Application: For use in SUMO modification reactions and SUMOylation pathway studies.
• Long Term Storage: -80°C.

Gene Information

• Gene Name: PIAS1 protein inhibitor of activated STAT, 1 [ Homo sapiens ]
• Synonyms:
  protein inhibitor of activated STAT, 1; GBP; ZMIZ3; DDXBP1; GU/RH-II; MGC141878; MGC141879; PIAS1; E3 SUMO-protein ligase PIAS1; gu-binding protein; AR interacting protein; DEAD/H box-binding protein 1; RNA helicase II-binding protein; zinc finger, MIZ-type containing 3; protein inhibitor of activated STAT protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; protein inhibitor of activated STAT-1; Gu-binding protein; Protein inhibitor of activated STAT protein 1
• Gene ID: 8554
• mRNA Refseq: NM_016166
• Protein Refseq: NP_057250
• MIM: 603566
• UniProt ID: O75925
• Chromosome Location: 15q
• Pathway: Jak-STAT signaling pathway; Pathways in cancer; Small cell lung cancer; Ubiquitin mediated proteolysis
• Function: transcription coactivator activity; transcription corepressor activity; DNA binding; SUMO ligase activity; androgen receptor binding; enzyme binding; metal ion binding; protein binding; zinc ion binding