PIAS2

  • Official Full Name

    protein inhibitor of activated STAT, 2
  • Overview

    This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
  • Synonyms

    PIAS2;protein inhibitor of activated STAT, 2;E3 SUMO-protein ligase PIAS2;miz;PIASX ALPHA;PIASX BETA;zinc finger;MIZ type containing 4;ZMIZ4;DAB2-interacting protein;zinc finger, MIZ-type containing 4;msx-interacting zinc finger protein;protei

Recombinant Proteins

  • Human
  • Chicken
  • Rat
  • E.coli
  • Mammalian Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PIAS2-1703H Recombinant Human PIAS2, GST-tagged E.coli Human GST 1-346aa
PIAS2-2335C Recombinant Chicken PIAS2 Mammalian Cells Chicken His
PIAS2-326H Recombinant Human PIAS2 Protein, His-tagged E.coli Human His
PIAS2-4442R Recombinant Rat PIAS2 Protein Mammalian Cells Rat His
PIAS2-3203HCL Recombinant Human PIAS2 293 Cell Lysate HEK293 Human Non
PIAS2-3204HCL Recombinant Human PIAS2 293 Cell Lysate HEK293 Human Non
PIAS2-4102R Recombinant Rat PIAS2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PIAS2-4102R-B Recombinant Rat PIAS2 Protein Pre-coupled Magnetic Beads HEK293 Rat

    Involved Pathway

    PIAS2 involved in several pathways and played different roles in them. We selected most pathways PIAS2 participated on our site, such as Ubiquitin mediated proteolysis,Jak-STAT signaling pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway IL29,STAT1A,SOCS3,IFNA5,PIK3R3A,IFNAR2,PTPN2,PTPN6,AOX3L1,IFNA8
    Ubiquitin mediated proteolysis BIRC8,UBR5,NEDD4L,RCHY1,CUL3,FLJ11011L,BIRC7,UBE2Q2,UBE2K,RBX1
    Pathways in cancer MMP1A,IGF1R,Fasl,TRAF3,PIK3CB,LPAR4,NRAS,PDGFRA,FGF13,GRB2
    Small cell lung cancer LAMB3,PIK3R2,LAMA3,CCND1,PTK2,PIK3CD,XIAP,BIRC7,LAMB2,LAMA1

    Protein Function

    PIAS2 has several biochemical functions, for example, DNA binding,SUMO ligase activity,androgen receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS2 itself. We selected most functions PIAS2 had, and list some proteins which have the same functions with PIAS2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HNRPK,DLX2B,BLZF1,JUNBB,ATF4B1,TBPL2,RBL2,ABL1,PREB,HIST4H4
    ligase activity RNF19B,RNF146,RAG1,RNF144AA,RNF34,MARCH3,UBE3B,SMURF2,NAPRT,RNF216
    androgen receptor binding RNF4,RB1,CALR,TRIM68,SMARCA4,DAXX,FOXH1,KDM4C,NSD1,TCF21
    SUMO ligase activity PIAS1,PIAS4
    transcription coactivator activity SCAND1,TBPL1,COPS5,ESR2,NPM1,DDX5,MED6,PARK7,ARNT,JUPA
    zinc ion binding TNP2,TRIM48,ADAM5P,TRIM13,USP3,ZNF92,RNF148,RNF41,JHDM1D,LHX6
    ubiquitin protein ligase binding TRAF1,STX8,AICDA,TRAF2,AXIN1,NFKBIA,SCN5A,SMAD6,TANK,ARRB2
    protein binding NHLH2,RBBP4,CEBPG,AP1S2,JAK2,CYC1,KLF13,TMEM199,C2orf57,IER3
    transcription factor binding MSX2,NR0B1,GATA6,SMAD2,RORA,CDK9,MAFB,MED6,PPP1R13BB,HMGB1

    Interacting Protein

    PIAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS2.

    UBE2I;CCNDBP1;SUMO1;NAV2

    PIAS2 Related Signal Pathway

    Resources

    References

    • Holloway, G; Dang, VT; et al. Rotavirus inhibits IFN-induced STAT nuclear translocation by a mechanism that acts after STAT binding to importin-alpha. JOURNAL OF GENERAL VIROLOGY 95:1723-1733(2014).
    • Abkhezr, M; Dryer, SE; et al. Angiotensin II and Canonical Transient Receptor Potential-6 Activation Stimulate Release of a Signal Transducer and Activator of Transcription 3-Activating Factor from Mouse Podocytes. MOLECULAR PHARMACOLOGY 86:150-158(2014).

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