PIP5K1A
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Official Full Name
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
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Overview
Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. Contributes to the activation of PLD2. -
Synonyms
PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1 alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- E.coli
- HEK293
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
PIP5K1A involved in several pathways and played different roles in them. We selected most pathways PIP5K1A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIP5K1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | CDIPT;PLCD1B;MTMR3;PLCH2;MTMR7B;IPPK;MINPP1B;MTMR7A;ITPKC |
| Metabolic pathways | PIK3C2B;CYP2C55;PLCH1;SGMS1;ALDH4A1;UGT1A7C;SDHA;Aldh1a7;TDO2 |
| Phosphatidylinositol signaling system | CALM3B;PIK3R3;INPP5E;PIK3C2A;INPP4A;CALML5;PIP4K2AA;PIP5K1A;MTMR1A |
| Phospholipase D signaling pathway | GRM7;INSR;PIP5K1B;AGPAT4;RHOA;MTOR;IL-8;SHC3;SHC4 |
| Endocytosis | RAB11FIP4B;RAB35B;EPN2;CHMP2B;KIF5A;DAB2;RAB7;TGFB2;STRUMPELLIN |
| Fc gamma R-mediated phagocytosis | MAP2K1;PIK3CB;PLCG1;PIK3R1;FCGR1A;PIK3R3;PIK3R2;RPS6KB2;SPHK1 |
| Regulation of actin cytoskeleton | ARHGEF7B;KRAS;ITGB8;ARPC5LB;PTK2AA;PIP5K1BB;ARHGEF7A;FGF5;ITGA3 |
| Choline metabolism in cancer | DGKQ;DGKB;WASF1;MAP2K2;MAPK1;PIK3R5;PRKCB;CHKB;HIF1A |
PIP5K1A has several biochemical functions, for example, 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIP5K1A itself. We selected most functions PIP5K1A had, and list some proteins which have the same functions with PIP5K1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-4-phosphate 5-kinase activity | PIP4K2B;PIP5K1C;PIP4K2A;PIP5K1A;PIKFYVE;PIP4K2C;PIP5K1B;PIP5KL1 |
| ATP binding | BCS1L;MAPK14;UBE2F;CKMT1A;MAGI3;ABCB1;ATAD1A;C10orf2;TLK1A |
| kinase binding | GFAP;TRADD;HPCA;RPS3;DLG4;ATF5;TAX1BP1;TOLLIP;SIT1 |
| protein binding | CCHCR1;KRTAP8-1;PRSS8;MRC1;EIF4B;LGALS13;DPYD;CYBB;KHDC1B |
PIP5K1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIP5K1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIP5K1A.
CADPS; ITGB1BP2; ARL14
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