PLAU

  • Official Full Name

    plasminogen activator, urokinase

  • Overview

    This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Synonyms

    PLAU; PLAU plasminogen activator, urokinase; ATF; UPA; URK; u-PA urokinase-type plasminogen activator; OTTHUMP00000019849; OTTHUMP00000019850; OTTHUMP00000019851; U-plasminogen activator; plasminogen activator, urinary.;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • Human urine
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Yeast
  • C
  • His
  • Avi
  • Flag
  • His (Fc)
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • 6×His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLAU-1108H Active Recombinant Human PLAU protein, His-tagged HEK293 His Met1-Leu431
Human PLAU-31689TH Active Native Human Urokinase protein Human urine N/A 411 amino acids
Human PLAU-8456H Active Native Human PLAU Human N/A
Human PLAU-702H Recombinant Human Plasminogen Activator, Urokinase Insect Cell N/A
Human PLAU-30029TH Recombinant Human PLAU N/A
Human PLAU-1296H Recombinant Human Plasminogen Activator, Urokinase Insect Cell N/A
Human PLAU-314H Recombinant Human PLAU protein, His-tagged HEK293 His Ser21-Leu431
Human PLAU-2467H Recombinant Human Plasminogen Activator, Urokinase Insect Cell N/A
Human PLAU-389H Recombinant Human PLAU Mammalian Cell His
Human PLAU-1734HCL Recombinant Human PLAU cell lysate Human Cell N/A
Human PLAU-1697H Recombinant Human PLAU Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PLAU-P009H Recombinant Human PLAU therapeutic protein E.coli N/A 276 Aa
Human CAB11591MH Mouse Monoclonal Antibody to Human Plasminogen Activator, Urokinase Mouse N/A
Human PLAU-4475H Recombinant Human PLAU protein, His-tagged E.coli His 21-431aa
Human PLAU-23H Recombinant Human PLAU Protein (Ser21-Leu431), N-6×His tagged E.coli N-6×His Ser21-Leu431
Human PLAU-22H Native Human PLAU protein Human urine N/A
Human PLAU -14H Native Human HMW urokinase, fluorescein labeled Human urine N/A
Human PLAU-806H Recombinant Human PLAU Protein HEK293 431
Human PLAU-6401H Recombinant Human PLAU Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PLAU -15H Native Human HMW urokinase, HRP conjugate Human urine N/A
Human PLAU-31777TH Native Human Human SERPINE1 E.coli N/A
Human PLAU-1868H Recombinant Human PLAU Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLAU-31687TH Native Human PLAU N/A 411 amino acids
Human PLAU-1393HFL Recombinant Full Length Human PLAU Protein, C-Flag-tagged Mammalian cells Flag
Human PLAU-1697H-B Recombinant Human PLAU Protein Pre-coupled Magnetic Beads HEK293
Mouse Plau-580M Recombinant Mouse Plau protein, His & T7-tagged E.coli His/T7 Ile180~Phe433 (Accession # P06869)
Mouse Plau-5464M Recombinant Mouse Plasminogen Activator, Urokinase Insect Cell N/A
Mouse Plau-1294M Recombinant Mouse Plasminogen Activator, Urokinase Insect Cell N/A
Mouse Plau-1298M Recombinant Mouse Plau Protein Insect Cell N/A
Mouse PLAU-12913M Recombinant Mouse PLAU Protein Mammalian Cell His
Mouse PLAU-6811M Recombinant Mouse PLAU Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Plau-268M Recombinant Mouse Plau Protein, Gly21-Phe433, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Gly21-Phe433
Mouse Plau-4908M Recombinant Mouse Plau Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Plau-6774M Recombinant Mouse Plau Protein (Gly21-Lys157), C-His tagged Yeast C-His Gly21-Lys157
Mouse PLAU-6811M-B Recombinant Mouse PLAU Protein Pre-coupled Magnetic Beads HEK293
Rat Plau -97R Recombinant Active Rat Urokinase, HMW Insect Cell N/A
Rat Plau-1297R Recombinant Rat Plasminogen Activator, Urokinase Insect Cell N/A
Rat Plau-582R Recombinant Rat Plau protein, His-tagged E.coli His Ser17~Phe432
Rat Plau-1161R Recombinant Rat Plau protein, His-tagged HEK293 His Met1-Phe432
Rabbit PLAU -91R Recombinant Active Rabbit Urokinase Insect Cell N/A
Dog PLAU-701D Recombinant Dog Plasminogen Activator, Urokinase Insect Cell N/A
Cattle PLAU-391C Recombinant Cattle PLAU Protein, His-tagged E.coli N-His Ser21-Phe179
Pig PLAU -85P Recombinant Active Porcine Urokinase Insect Cell N/A
Pig PLAU-581P Recombinant Pig PLAU protein, His & T7-tagged E.coli His/T7 Ser21~Pro168 (Accession # P04185)
Chicken PLAU-6993C Recombinant Chicken PLAU Mammalian Cell His
Kit-0702 PLAU (Human) Chromogenic Activity Assay Kit (Direct Assay) N/A
Kit-0703 PLAU (Human) Chromogenic Activity Assay Kit (Indirect Assay) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PLAU involved in several pathways and played different roles in them. We selected most pathways PLAU participated on our site, such as NF-kappa B signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayCcl21c;IKBKG;GM10591;TNFAIP3;LTA;PRKCQ;PRKCB;MYD88;CFLAR
Complement and coagulation cascadesKLKB1;C3AR1;CFD;C8A;C1QA;C6;GM5077;SERPING1;C2
Transcriptional misregulation in cancerAff1;BCL2A1A;TAF15;BCL6;SPINT1;HOXA11;PTK2;HIST3H3;CCNT1
Proteoglycans in cancerPIK3R5;CBLC;WNT5A;AKT1;ERBB3;ANK2;WNT8B;CTTN;PTPN6
MicroRNAs in cancerMMP16;CCND1;HRAS;DNMT3A;MTOR;NFKB1;MDM2;MAPK7;EZR

PLAU has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAU itself. We selected most functions PLAU had, and list some proteins which have the same functions with PLAU. You can find most of the proteins on our site.

Function Related Protein
protein bindingCAND1;TOM1;TCF4;NCOA1;PPP1R13L;CGA;NHP2L1;RAB11FIP3;Ctsl
serine-type endopeptidase activityLONP1;KEX2;PRSS22;PRSS28;TMPRSS4A;TMPRSS13B;TPP1;PCSK5B;TRY

PLAU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAU here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAU.

SERPINE1; MYC; ALAS1; BTK

Research Area

Related articles

Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
Lu, CH; Lee, RKK; et al. Involvement of the Serine Protease Inhibitor, SERPINE2, and the Urokinase Plasminogen Activator in Cumulus Expansion and Oocyte Maturation. PLOS ONE 8:-(2013).
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