plau

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plau

Official Full Name plasminogen activator, urokinase
Background This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms PLAU; PLAU plasminogen activator, urokinase; ATF; UPA; URK; u-PA urokinase-type plasminogen activator; OTTHUMP00000019849; OTTHUMP00000019850; OTTHUMP00000019851; U-plasminogen activator; plasminogen activator, urinary.
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Human urine
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • NS0
    • Tag :
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11591MH Mouse Monoclonal Antibody to Human Plasminogen Activator, Urokinase Mouse N/A
    Human PLAU -14H Native Human HMW urokinase, fluorescein labeled Human urine N/A
    Human PLAU -15H Native Human HMW urokinase, HRP conjugate Human urine N/A
    Human PLAU-1108H Recombinant Human PLAU Protein, His-tagged NS0 His
    Human PLAU-1296H Recombinant Human Plasminogen Activator, Urokinase Insect Cell N/A
    Human PLAU-1734HCL Recombinant Human PLAU cell lysate Human Cell N/A
    Human PLAU-1868H Recombinant Human PLAU Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLAU-22H Native Human PLAU protein Human urine N/A
    Human PLAU-2467H Recombinant Human Plasminogen Activator, Urokinase Insect Cell N/A
    Human PLAU-30029TH Recombinant Human PLAU N/A
    Human PLAU-314H Recombinant Human PLAU protein, His-tagged HEK293 His
    Human PLAU-31687TH Native Human PLAU N/A
    Human PLAU-31689TH Native Human Urokinase protein Human urine N/A
    Human PLAU-31777TH Native Human Human SERPINE1 E.coli N/A
    Human PLAU-389H Recombinant Human PLAU Mammalian Cell His
    Human PLAU-702H Recombinant Human Plasminogen Activator, Urokinase Insect Cell N/A
    Human PLAU-8456H Native Human PLAU Human N/A
    Human PLAU-P009H Recombinant Human PLAU therapeutic protein E.coli N/A
    Mouse PLAU-12913M Recombinant Mouse PLAU Protein Mammalian Cell His
    Mouse Plau-1294M Recombinant Mouse Plasminogen Activator, Urokinase Insect Cell N/A
    Mouse Plau-1298M Recombinant Mouse Plau Protein Insect Cell N/A
    Mouse Plau-5464M Recombinant Mouse Plasminogen Activator, Urokinase Insect Cell N/A
    Mouse Plau-580M Recombinant Mouse Plau protein, His & T7-tagged E.coli His/T7
    Rat Plau -97R Recombinant Active Rat Urokinase, HMW Insect Cell N/A
    Rat Plau-1161R Recombinant Rat Plau Protein, His-tagged HEK293 His
    Rat Plau-1297R Recombinant Rat Plasminogen Activator, Urokinase Insect Cell N/A
    Rat Plau-582R Recombinant Rat Plau protein, His-tagged E.coli His
    Dog PLAU-701D Recombinant Dog Plasminogen Activator, Urokinase Insect Cell N/A
    Rabbit PLAU -91R Recombinant Active Rabbit Urokinase Insect Cell N/A
    Chicken PLAU-6993C Recombinant Chicken PLAU Mammalian Cell His
    Pig PLAU -85P Recombinant Active Porcine Urokinase Insect Cell N/A
    Pig PLAU-581P Recombinant Pig PLAU protein, His & T7-tagged E.coli His/T7
    Kit-0702 PLAU (Human) Chromogenic Activity Assay Kit (Direct Assay) N/A
    Kit-0703 PLAU (Human) Chromogenic Activity Assay Kit (Indirect Assay) N/A

    plau involved in several pathways and played different roles in them. We selected most pathways plau participated on our site, such as NF-kappa B signaling pathway, Complement and coagulation cascades, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with plau were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway XIAP; LTBR; NFKB1; PLAU; ERC1; MAP3K7; TNFRSF11A; BTK; IL-8; TRAF2
    Complement and coagulation cascades C5; SERPINE1; SERPINA1A; F2R; PROS1; SERPINA5; TFPI; F8; Hc; C4BPB
    Transcriptional misregulation in cancer SS18; ATF1; CCNT1; TRAF1; PTCRA; SUPT3H; NFKB1; IL1R2; ELANE; HIST1H3E
    Proteoglycans in cancer DROSHA; PIK3CB; ANK2; PXN; PIK3CG; TLR4; ARHGEF1; EZR; WNT9B; HIF1A
    MicroRNAs in cancer Pdgfa&Pdgfb; KRAS; RDX; PLCG1; TPM1; IRS2; CCNG1; PRKCB; FGFR3; TTC6

    plau has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by plau itself. We selected most functions plau had, and list some proteins which have the same functions with plau. You can find most of the proteins on our site.

    Function Related Protein
    protein binding YARS2; PEX11A; WAC; CDIPT; JDP2; FOXO3; LARP4; B9D2; SOX15; GEMIN8
    serine-type endopeptidase activity CTSC; CFI; F2; PRSS52; TMPRSS11B; PRSS58; CTRB1; GZMC; C1S; Gzmd

    plau has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with plau here. Most of them are supplied by our site. Hope this information will be useful for your research of plau.

    SERPINE1; MYC; ALAS1; BTK

    Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
    Lu, CH; Lee, RKK; et al. Involvement of the Serine Protease Inhibitor, SERPINE2, and the Urokinase Plasminogen Activator in Cumulus Expansion and Oocyte Maturation. PLOS ONE 8:-(2013).

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