Recombinant Human PLAU Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PLAU-6401H
• Product Overview: PLAU MS Standard C13 and N15-labeled recombinant protein (NP_002649) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.5 kDa
• AA Sequence: MRALLARLLLCVLVVSDSKGSNELH QVPSNCDCLNGGTCVSNKYFSNIHW CNCPKKFGGQHCEIDKSKTCYEGNG HFYRGKASTDTMGRPCLPWNSATVL QQTYHAHRSDALQLGLGKHNYCRNP DNRRRPWCYVQVGLKPLVQECMVHD CADGKKPSSPPEELKFQCGQKTLRP RFKIIGGEFTTIENQPWFAAIYRRH RGGSVTYVCGGSLISPCWVISATHC FIDYPKKEDYIVYLGRSRLNSNTQG EMKFEVENLILHKDYSADTLAHHND IALLKIRSKEGRCAQPSRTIQTICL PSMYNDPQFGTSCEITGFGKENSTD YLYPEQLKMTVVKLISHRECQQPHY YGSEVTTKMLCAADPQWKTDSCQGD SGGPLVCSLQGRMTLTGIVSWGRGC ALKDKPGVYTRVSHFLPWIRSHTKE ENGLALTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PLAU plasminogen activator, urokinase [ Homo sapiens (human) ]
• Official Symbol: PLAU
• Synonyms: PLAU; plasminogen activator, urokinase; urokinase-type plasminogen activator; UPA; URK; U-plasminogen activator; plasminogen activator, urinary; ATF; QPD; u-PA; BDPLT5
• Gene ID: 5328
• mRNA Refseq: NM_002658
• Protein Refseq: NP_002649
• MIM: 191840
• UniProt ID: P00749