Recombinant Rat Plasminogen Activator, Urokinase

• Cat.No.: Plau-1297R
• Product Overview: RecombinantRat High Molecular Weight two-chain Plau.

Specification

• Species: Rat
• Source: Insect Cells
• Tag: Non
• Description: Plauisan enzyme that in humans is encoded by the Plau gene. This gene encodes aserine protease involved in degradation of the extracellular matrix andpossibly tumor cell migration and proliferation. A specific polymorphism inthis gene may be associated with late-onset Alzheimer disease and also withdecreased affinity for fibrin-binding. The protein encoded by this geneconverts plasminogen to plasmin by specific cleavage of an Arg-Val bond inplasminogen. This gene"s proprotein is cleaved at a Lys-Ile bond by plasminto form a two-chain derivative in which a single disulfide bond connects theamino-terminal A-chain to the catalytically active, carboxy-terminal B-chain.
• Formulation: Frozen liquid in 0.05M Sodium Acetate+0.1M NaCI+1mM EDTA, pH 5.0.
• Molecular Weight: 44.0 kDa
• Concentration: 2.0 mg/mL
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: Plau

Gene Information

• Gene Name: Plauplasminogen activator, urokinase [ Rattus norvegicus ]
• Synonyms: Plau; plasminogenactivator, urokinase; UPAM; MGC124931; urokinase-typeplasminogen activator; uPA; U-plasminogen activator; Urinary plasminogenactivator, urokinase
• Gene ID: 25619
• mRNA Refseq: NM_013085
• Protein Refseq: NP_037217
• UniProt ID: Q3KR76
• Chromosome Location: 15p16
• Pathway: BloodClotting Cascade; Complement and Coagulation Cascades; Complement andcoagulation cascades; Dissolution of Fibrin Clot; Endochondral Ossification;Hemostasis; Wnt Signaling Pathway; Wnt Signaling Pathway and Pluripotency
• Function: kinase activity; peptidase activity; serine-typeendopeptidase activity