Recombinant Human Plasminogen Activator, Urokinase

• Cat.No.: PLAU-1296H
• Product Overview: Recombinant HumanLMW-uPA is produced in insect cell culture as the single-chain LMW form forPLAU and receptor binding studies.

Specification

• Cat. No.: PLAU-1296H
• Description: PLAU is involved indegradation of the extracellular matrix and possibly tumor cell migration andproliferation. This protein converts Plasminogen to Plasmin by specificcleavage of an Arg-Val bond in Plasminogen. Plasmin in turn cleaves thisprotein at a Lys-Ile bond to form a two-chain derivative in which a singledisulfide bond connects the amino-terminal A-chain to the catalyticallyactive, carboxy-terminal B-chain. This two-chain derivative is also calledHMW-uPA (high molecular weight uPA). HMW-uPA can be further processed intoLMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chainA (A1) and an amino- terminal fragment. LMW-uPA is proteolytically active butdoes not bind to the uPA receptor.
• Source: Insect Cell Culture
• Species: Human
• Formulation: Frozen liquid in0.05M Sodium Acetate pH 5.0+0.1M NaCI+1mM EDTA.
• Molecular Weight: 54.0 kDa
• Concentration: 2.5 mg/mL
• Volume: 0.04 mL
• Storage: Store at -70°C.
• OfficialSymbol: PLAU

Gene Information

• Gene Name: PLAU plasminogen activator,urokinase [ Homo sapiens ]
• Synonyms: PLAU; plasminogenactivator, urokinase; ATF; QPD; UPA; URK; u-PA; BDPLT5; urokinase-type plasminogen activator; OTTHUMP00000019849;OTTHUMP00000019850; OTTHUMP00000019851; U-plasminogen activator; plasminogenactivator, urinary
• Gene ID: 5328
• mRNA Refseq: NM_002658
• Protein Refseq: NP_002649
• MIM: 191840
• UniProt ID: P00749
• Chromosome Location: 10q24
• Pathway: ATF-2transcription factor network; Blood Clotting Cascade; Complement andCoagulation Cascades; Complement and coagulation cascades; DNA damageresponse (only ATM dependent); Dissolution of Fibrin Clot; E2F transcriptionfactor network; Endochondral Ossification; FGF signaling pathway; Hemostasis;Osteopontin Signaling; Osteopontin-mediated events; Validated transcriptionaltargets of AP1 family members Fra1 and Fra2; Wnt Signaling Pathway; amb2Integrin signaling
• Function: peptidaseactivity; protein binding; serine-type endopeptidase activity